Showing items 1 - 20 of 263

Your selections:

Inattention and disordered gaming : does culture matter?

- Stavropoulos, Vasileios, Baynes, Kyi, O’Farrel, Dominic, Gomez, Rapson, Mueller, Astrid, Yucel, Murat, Griffiths, Mark

  • Authors: Stavropoulos, Vasileios , Baynes, Kyi , O’Farrel, Dominic , Gomez, Rapson , Mueller, Astrid , Yucel, Murat , Griffiths, Mark
  • Date: 2020
  • Type: Text , Journal article
  • Relation: Psychiatric Quarterly Vol. 91, no. 2 (2020), p. 333-348
  • Full Text: false
  • Reviewed:
  • Description: Problematic gaming has emerged as a contemporary concern, leading to the introduction of the diagnostic term ‘Internet Gaming Disorder’ (IGD; American Psychiatric Association). The present study aims to empirically assess the association between inattention and IGD, in the light of variable levels of vertical-individualism that reflects cultural inclinations towards independence, competitiveness, and hierarchy. The participants (N = 1032) comprised a normative cohort of Massively Multiplayer Online (MMO) gamers (Mage = 24 years; 48.7% male). IGD was measured with the nine-item short-form IGD Scale (IGD9-SF), inattention with the Attention Deficit Hyperactivity Disorder (ADHD) Self-Report Scale, and vertical individualism with the Individualism-Collectivism Questionnaire. Complex hierarchical and moderated regressions were employed. Findings demonstrated an association between IGD and inattention, and additionally showed that this association was exacerbated by a more vertically-individualistic cultural orientation without significant gender differences. The need of differentially addressing IGD risk among inattentive gamers of diverse cultural orientation is highlighted. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.

Neural suppression of miRNA-181a in the kidney elevates renin expression and exacerbates hypertension in Schlager mice

- Jackson, Kristy, Gueguen, Cindy, Lim, Kyungjoon, Eikelis, Nina, Stevenson, Emily, Charchar, Fadi, Lambert, Gavin, Burke, Sandra, Paterson, Madeleine, Marques, Francine, Head, Geoffrey

  • Authors: Jackson, Kristy , Gueguen, Cindy , Lim, Kyungjoon , Eikelis, Nina , Stevenson, Emily , Charchar, Fadi , Lambert, Gavin , Burke, Sandra , Paterson, Madeleine , Marques, Francine , Head, Geoffrey
  • Date: 2020
  • Type: Text , Journal article
  • Relation: Hypertension Research Vol. 43, no. 11 (2020), p. 1152-1164
  • Full Text: false
  • Reviewed:
  • Description: BPH/2J mice are a genetic model of hypertension with overactivity of the sympathetic nervous system (SNS) and renin–angiotensin system (RAS). BPH/2J display higher renal renin mRNA and low levels of its negative regulator microRNA-181a (miR-181a). We hypothesise that high renal SNS activity may reduce miR-181a expression, which contributes to elevated RAS activity and hypertension in BPH/2J. Our aim was to determine whether in vivo administration of a renal-specific miR-181a mimic or whether renal denervation could increase renal miR-181a abundance to reduce renal renin mRNA, RAS activity and hypertension in BPH/2J mice. Blood pressure (BP) in BPH/2J and normotensive BPN/3J mice was measured via radiotelemetry probes. Mice were administered miR-181a mimic or a negative control (1–25 nmol, i.v., n = 6–10) with BP measured for 48 h after each dose or they underwent renal denervation or sham surgery (n = 7–9). Injection of 5–25 nmol miR-181a mimic reduced BP in BPH/2J mice after 36–48 h (−5.3 ± 1.8, −6.1 ± 1.9 mmHg, respectively, P < 0.016). Treatment resulted in lower renal renin and inflammatory marker (TLR4) mRNA levels in BPH/2J. The mimic abolished the hypotensive effect of blocking the RAS with enalaprilat (P < 0.01). No differences between mimic or vehicle were observed in BPN/3J mice except for a higher level of renal angiotensinogen in the mimic-treated mice. Renal miR-181a levels that were lower in sham BPH/2J mice were greater following renal denervation and were thus similar to those of BPN/3J. Our findings suggest that the reduced renal miR-181a may partially contribute to the elevated BP in BPH/2J mice, through an interaction between the renal sympathetic nerves and miR-181a regulation of the RAS. © 2020, The Japanese Society of Hypertension.
  • Description: This work was supported by a grant from the National Health & Medical Research Council of Australia (NHMRC, Project grant 1065714) and in part by the Victorian Government’s OIS Program. Investigators were supported by NHMRC/National Heart Foundation (NHF) Postdoctoral Fellowships (NHMRC APP1091688 to KLJ, NHMRC APP1052659 and NHF PF12M6785 and 101185 to FZM) and NHMRC Research Fellowships (APP1042492 to GWL and APP1002186 to GAH).

TIMP-2 regulates proliferation, invasion and STAT3-mediated cancer stem cell-dependent chemoresistance in ovarian cancer cells

- Escalona, Ruth, Bilandzic, Maree, Western, Patrick, Kadife, Elif, Kannourakis, George, Findlay, Jock, Ahmed, Nuzhat

  • Authors: Escalona, Ruth , Bilandzic, Maree , Western, Patrick , Kadife, Elif , Kannourakis, George , Findlay, Jock , Ahmed, Nuzhat
  • Date: 2020
  • Type: Text , Journal article
  • Relation: BMC Cancer Vol. 20, no. 1 (2020), p.
  • Full Text:
  • Reviewed:
  • Description: Background: The metzincin family of metalloproteinases and the tissue inhibitors of metalloproteinases (TIMPs) are essential proteins required for biological processes during cancer progression. This study aimed to determine the role of TIMP-2 in ovarian cancer progression and chemoresistance by reducing TIMP-2 expression in vitro in Fallopian tube secretory epithelial (FT282) and ovarian cancer (JHOS2 and OVCAR4) cell lines. Methods: FT282, JHOS2 and OVCAR4 cells were transiently transfected with either single or pooled TIMP-2 siRNAs. The expression of different genes after TIMP-2 knock down (T2-KD) or in response to chemotherapy was determined at the mRNA level by quantitative real time PCR (qRT-PCR) and at the protein level by immunofluorescence. Sensitivity of the cell lines in response to chemotherapy after TIMP-2 knock down was investigated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and 5-Ethynyl-2′-deoxyuridine (EdU) assays. Cell invasion in response to TIMP-2 knockdown was determined by xCELLigence. Results: Sixty to 90 % knock down of TIMP-2 expression was confirmed in FT282, OVCAR4 and JHOS2 cell lines at the mRNA and protein levels. TIMP-2 knock down did not change the mRNA expression of TIMP-1 or TIMP-3. However, a significant downregulation of MMP-2 in T2-KD cells occurred at both the protein and activation levels, compared to Control (Cont; scrambled siRNA) and Parental cells (P, transfection reagent only). In contrast, membrane bound MT1-MMP protein levels were significantly upregulated in T2-KD compared to Cont and P cells. T2-KD cells exhibited enhanced proliferation and increased sensitivity to cisplatin and paclitaxel treatments. Enhanced invasion was observed in the T2-KD-JOSH2 and OVCAR4 cells but not in T2-KD-FT282 cells. Treatment with cisplatin or paclitaxel significantly elevated the expression of TIMP-2 in Cont cells but not in T2-KD cells, consistent with significantly elevated expression of chemoresistance and CSC markers and activation of STAT3. Furthermore, a potent inhibitor of STAT3 activation, Momelotinib, suppressed chemotherapy-induced activation of P-STAT3 in OVCAR4 cells with concomitant reductions in the expression of chemoresistance genes and CSC markers. Conclusions: The above results suggest that TIMP-2 may have a novel role in ovarian cancer proliferation, invasion and chemoresistance. © 2020 The Author(s).

Quality indicators for a community-based wound care centre : an integrative review

- Seaton, Philippa, Cant, Robyn, Trip, Henrietta

  • Authors: Seaton, Philippa , Cant, Robyn , Trip, Henrietta
  • Date: 2020
  • Type: Text , Journal article
  • Relation: International Wound Journal Vol. 17, no. 3 (2020), p. 587-600
  • Full Text: false
  • Reviewed:
  • Description: The purpose of this review was to identify the role and contribution of community-based nurse-led wound care as a service delivery model. Centres increasingly respond proactively to assess and manage wounds at all stages – not only chronic wound care. We conducted an integrative review of literature, searching five databases, 2007–2018. Based on inclusion and exclusion criteria, we systematically approached article selection and all three authors collaborated to chart the study variables, evaluate data, and synthesise results. Eighteen studies were included, representing a range of care models internationally. The findings showed a need for nurse-led clinics to provide evidence-based care using best practice guidelines for all wound types. Wound care practices should be standardised across the particular service and be integrated with higher levels of resources such as investigative services and surgical units. A multi-disciplinary approach was likely to achieve better patient outcomes, while patient-centred care with strong patient engagement was likely to assist patients' compliance with treatment. High-quality community-based wound services should include nursing leadership based on a hub-and-spoke model. This is ideally patient-centred, evidence-based, and underpinned by a commitment to developing innovations in terms of treatment modalities, accessibility, and patient engagement. © 2020 Medicalhelplines.com Inc and John Wiley & Sons Ltd
  • Description: This study was supported by The Nurse Maude Association, Christchurch, New Zealand, a community‐based nursing service in New Zealand. We acknowledge the contribution of the following Nurse Maude Association staff: Mary‐Anne Stone (MPH), Senior Manager of Research, Innovation and Aged Residential Care. Cathy Hammond (MA–Clinical Nursing), Clinical Nurse Specialist – Specialist Wound Service. Denise Brankin (RN, PGDipHSc), Service Manager, Specialty Nursing Services. Gill Coe (BA), Research Officer.creative

Thirty-seven jump-landing biomechanical variables are associated with asymptomatic patellar tendon abnormality and patellar tendinopathy : A systematic review

- Harris, Meaghan, Schultz, Adrian, Drew, Michael, Rio, Ebonie, Adams, Stuart, Edwards, Suzi

  • Authors: Harris, Meaghan , Schultz, Adrian , Drew, Michael , Rio, Ebonie , Adams, Stuart , Edwards, Suzi
  • Date: 2020
  • Type: Text , Journal article , Review
  • Relation: Physical Therapy in Sport Vol. 45, no. (2020), p. 38-55
  • Full Text: false
  • Reviewed:
  • Description: Objective: To identify studies that report three-dimensional (3D) biomechanical analysis of jump-landing tasks in relation to athletes with current patellar tendinopathy (PT), and/or asymptomatic with history of PT or patellar tendon abnormality (PTA) on diagnostic imaging. Methods: Five electronic databases were searched. Included articles were required to: (1) investigate the 3D biomechanics of a jump-landing task; (2) be cross-sectional or longitudinal in design; and (3) include participants that had symptomatic PT, were asymptomatic with a history of PT, asymptomatic with PTA on diagnostic imaging and/or asymptomatic with an unknown pathology or PT history. Results: Thirty-seven statistically significant jump-landing variables were associated with PT, history of PT and/or PTA. The only consistent variable that could be replicated between studies was knee flexion angle at initial foot-ground contact (IC) and an altered hip flexion/extension strategy during a horizontal land phase of a vertical stop-jump. Conclusion: Isolated vertical landings or take-offs alone may not be sensitive enough to identify key jump-landing variables associated with PT, thus clinicians and researchers should incorporate a whole jump-landing task with a horizontal landing component. Sagital plane hip and knee kinematics in a horizontal landing phase appear to provide the most valuable information for evaluating those with PT. (C) 2020 Elsevier Ltd. All rights reserved.

Developing Australia's first statewide trauma registry : What are the lessons?

- Cameron, Peter, Finch, Caroline, Gabbe, Belinda, Collins, Lisa, Smith, Karen, McNeil, John

  • Authors: Cameron, Peter , Finch, Caroline , Gabbe, Belinda , Collins, Lisa , Smith, Karen , McNeil, John
  • Date: 2004
  • Type: Text , Journal article
  • Relation: ANZ Journal of Surgery Vol. 74, no. 6 (2004), p. 424-428
  • Full Text: false
  • Reviewed:
  • Description: Trauma registries, like disease registries, provide an important analysis tool to assess the management of patient care. Trauma registries are well established and relatively common in the USA and have been used to change legislation, promote trauma prevention and to evaluate trauma system effectiveness. In Australia, the first truly statewide trauma registry was established in Victoria in 2001 with an estimated capture of 1700 major trauma cases annually. The Victorian State Trauma Registry, managed by the Victorian State Trauma Outcomes Registry and Monitoring (VSTORM) group, was established in response to a ministerial review of trauma and emergency services undertaken in 1997 to advise the Victorian Government on a best practice model of trauma service provision that was responsive to the particular needs of critically ill trauma patients. This taskforce recommended the establishment of a new system of care for major trauma patients in Victoria and a statewide trauma registry to monitor this new system. The development of the Victorian state trauma registry has shown that there are certain issues that must be resolved for successful implementation of any system-wide registry. This paper describes the issues faced by VSTORM in developing, implementing and maintaining a statewide trauma registry.
  • Description: 2003005108

Help-seeking by rural residents for mental health problems: The importance of agrarian values

- Judd, Fiona, Jackson, Henry, Komiti, Angela, Murray, Greg, Fraser, Caitlin, Grieve, Aaron, Gomez, Rapson

  • Authors: Judd, Fiona , Jackson, Henry , Komiti, Angela , Murray, Greg , Fraser, Caitlin , Grieve, Aaron , Gomez, Rapson
  • Date: 2006
  • Type: Text , Journal article
  • Relation: Australian and New Zealand Journal of Psychiatry Vol. 40, no. 9 (2006), p. 769-776
  • Full Text:
  • Reviewed:
  • Description: Objective: To examine the role of stoicism, self-efficacy and perceived stigma in predicting help-seeking by rural residents, for mental health problems. Method: A cross-sectional community survey was conducted with a sample of 467 rural residents (58% female), who completed self-report questionnaires assessing current levels of symptomatology, disability, perceived stigma, self-efficacy, stoicism, attitudes towards and experience of seeking help for psychological problems. Results: Overall, 7.6% (n = 129) of respondents had sought help from a general practitioner and/or mental health professional for psychological problems or a mental health issue. More women than men reported having sought such help. Lifetime help-seeking for a psychological problem or mental health issue was positively associated with higher levels of distress and lower levels of stoicism and, to a lesser extent, lower levels of self-efficacy. Conclusions: Efforts to improve help-seeking by rural residents for mental health problems should focus on understanding and addressing attitudes, such as stoicism which act as barriers to help-seeking. © 2006 The Authors; Journal compilation © 2006 The Royal Australian and New Zealand College of Psychiatrists.
  • Description: C1
  • Description: 2003002045

Mother-infant psychotherapy and perinatal psychiatry : Current clinical practice and future directions

- Galbally, Megan, Lewis, Andrew, Snellen, Martien, Paul, Campbell, Szego, Klara, Trauer, Tom

  • Authors: Galbally, Megan , Lewis, Andrew , Snellen, Martien , Paul, Campbell , Szego, Klara , Trauer, Tom
  • Date: 2006
  • Type: Text , Journal article
  • Relation: Australasian Psychiatry Vol. 14, no. 4 (2006), p. 384-389
  • Full Text: false
  • Reviewed:
  • Description: Objective: To explore trends in the practice of mother-infant psychotherapy among perinatal psychiatry clinicians based in Melbourne. Methods: A cross-sectional survey with a purpose designed self-report questionnaire was used to assess the attitudes and practices of 47 perinatal and infant psychiatry clinicians in their use and understanding of mother-infant psychotherapy. Results: Seventy per cent of clinicians in this field of psychotherapy who responded to the questionnaire subscribe to a psychodynamic model, although cognitive behavioural models are also used. The interventions were mostly used in conjunction with other interventions, would be more accurately described as 'parent-infant psychotherapy', and non-psychiatrists in the area tended to be more likely to be formally trained in psychotherapy, but only 4% were formally trained in specific mother-infant psychotherapy. There was a unanimous request for further clinical training in this area. Conclusions: The emerging field of perinatal psychiatry needs to develop coherent therapeutic models and conduct outcome trials on specific interventions. Specific trainings in these models, in assessment and in diagnostic frameworks are required to enhance clinical efficacy, for research and service development purposes. © 2006 Royal Australian and New Zealand College of Psychiatrists.
  • Description: C1
  • Description: 2003001670

Predictors of transformation to myelodysplasia/acute myelogenous leukemia (MDS/AML) in severe congenital neutropenia (CN)

- Boxer, Laurence, Bolyard, Audrey, Newburger, Peter, Bonilla, Mary Ann, Kannourakis, George, Dror, Yigal, Link, Daniel, Alter, Blanche, Rosenberg, Philip, Dale, David

Access to stroke care units in Australian public hospitals : Facts and temporal progress

- Cadilhac, Dominique, Lalor, Erin, Pearce, Dora, Levi, Christopher, Donnan, Geoffrey

  • Authors: Cadilhac, Dominique , Lalor, Erin , Pearce, Dora , Levi, Christopher , Donnan, Geoffrey
  • Date: 2006
  • Type: Text , Journal article
  • Relation: Internal Medicine Journal Vol. 36, no. 11 (2006), p. 700-704
  • Full Text: false
  • Reviewed:
  • Description: Background: There is level I evidence that management of stroke patients in stroke units (SU) improves outcomes (death and institutionalization) by approximately 20%. In Australia, there is uncertainty as to the proportion of incident cases that have access to SU. Recent national and State-based policy initiatives to increase access to SU have been taken. However, objective evidence related to SU implementation progress is lacking. The aims of the study were (i) to determine the number of SU in Australian acute public hospitals in 2004, (ii) to describe hospitals according to national SU policy criteria and (iii) to compare results to the 1999 survey to track progress. Methods: The method used in the study was a cross-sectional, postal survey technique. The participants were clinical representatives considered appropriate to describe stroke care within survey hospitals. Results: The outcome of the study was presence of a SU according to an accepted definition. Response rate was 261/301 (87%). Sixty-one sites (23%) had either a SU and/or a dedicated stroke team. Fifty sites claimed to have a SU (19%). New South Wales with 23 had the most number of SU. Based on policy criteria, up to 64 sites could have a SU. In 1999, there were 35 public hospitals with a SU. Conclusion: Access to SU in Australian public hospitals remains low compared with other countries (Sweden, 70%). Implementation strategies supported by appropriate health policy to improve access are needed. © 2006 Royal Australasian College of Physicians.

Coping patterns and psychosocial distress in female partners of prostate cancer patients

- Couper, Jeremy, Bloch, Sidney, Love, Anthony, Duchesne, Gillian, MacVean, Michelle, Kissane, David

  • Authors: Couper, Jeremy , Bloch, Sidney , Love, Anthony , Duchesne, Gillian , MacVean, Michelle , Kissane, David
  • Date: 2009
  • Type: Text , Journal article
  • Relation: Psychosomatics Vol. 50, no. 4 (2009), p. 375-382
  • Full Text: false
  • Reviewed:
  • Description: Background: With medical advances since the 1990s, a growing proportion of patients are living for many years with prostate cancer (PCA) and the consequences of its treatment. Objective: The authors investigated the experience of being diagnosed with cancer and the effects of its treatment on patients' partners. Method: The authors conducted an observational, longitudinal study of 103 couples facing the diagnosis of either localized (potentially curable) or metastatic (incurable) PCA at Time 1 and then 6 months later (Time 2). Results: At both Time 1 and Time 2, psychological distress, marital satisfaction, and family functioning were measured in patients and partners; coping was measured in partners only. Partner maladaptive coping patterns of avoidance and self-blame at Time 1 predicted greater partner psychological distress at Time 2, as did "wishful thinking" at Time 2. Discussion: Psychosocial interventions designed to promote adaptive coping in couples facing PCA warrant systematic study. (Psychosomatics 2009; 50: 375-382)

Problem behaviours in early primary school children : Australian normative data using the strengths and difficulties questionnaire

- Hayes, Louise

  • Authors: Hayes, Louise
  • Date: 2007
  • Type: Text , Journal article
  • Relation: Australian and New Zealand Journal of Psychiatry Vol. 41, no. 3 (Mar 2007), p. 231-238
  • Full Text:
  • Reviewed:
  • Description: Objective: This study provides normative and clinical levels of problem behaviours from a large community sample of Australian early primary school children. Method: From a large community sample (n = 1928) of children aged 5 to 10 years (mean = 7.70, SD = 0.89) normative data are provided using the teacher-reported version of the Strengths and Difficulties Questionnaire (SDQ). A response rate of 88% ensures the data are representative. Results: Mean scores on total difficulties between this Australian sample and UK norms were comparable. Some differences in the clinical cut-off scores are evident in the Australian sample, and adjusted clinical cut-offs are provided. Australian teacher reports of problem behaviour revealed lower clinical levels of emotional problems. Boys had significantly greater problems than girls on the Conduct, Hyperactivity, Peer and Prosocial scales. Overall, 5.3% of boys had scores in the clinical range on four of the five subscales. Comparisons of the factor structure revealed that for boys the Peer scale has two interpretations, with two items loading with Conduct problems and associated with greater problem behaviours. For girls, conduct problems are more strongly associated with poorer prosocial skills. Conclusions: Teachers are able provide valuable predictive information on externalizing behaviours. Australian normative comparisons reveal minor variations in teacher interpretation of items. The present data is representative of the Australian community and should be used to assess behaviour difficulties in early primary school children. Future studies on older age children are required to understand the developmental progression of problem behaviours in the community.
  • Description: C1
  • Description: 2003005423

Declining melatonin levels and older people. How old is old?

- Graham, D., McLachlan, Angus

  • Authors: Graham, D. , McLachlan, Angus
  • Date: 2004
  • Type: Text , Journal article
  • Relation: Neuroendocrinology Letters Vol. 25, no. 6 (2004), p. 415-418
  • Full Text:
  • Reviewed:
  • Description: Objectives: The purpose of this study was to investigate whether melatonin levels in older cohorts within the 'aged' population were significantly lower than in younger 'aged' individuals and hence point to a possible confound in cross-sectional studies which group individuals over 55 in one category. Setting and design: Melatonin levels of 35 North Queensland residents over 55 years of age living in an aged-care facility, a retirement village or the general community were compared across three age groups. Methods: Subjects were ten 56-65 year olds, eighteen 66-75 year olds and seven over-75 year olds. Information was obtained on sleep, awakening, medical conditions and medications, with subsequent exclusion of those with known medical conditions and/or medications. Melatonin was collected by salivary samples at 2200 hours and concentrations were determined by immunoassay. Results: Mean melatonin levels were significantly lower (p=.03) in the 'oldest' (over 75 yrs) group compared to the 'youngest' (56-65 yrs) group. Main findings: The results of this preliminary study indicate that within the older population, melatonin levels appear to decline significantly with age. Conclusions: Future studies of melatonin and ageing may benefit from a longitudinal approach, with older subjects sampled across time. Copyright © Neuroendocrinology Letters.
  • Description: C1

A review of mathematical models used to determine sperm donor limits for infertility treatment

- Sawyer, Neroli, McDonald, John

  • Authors: Sawyer, Neroli , McDonald, John
  • Date: 2008
  • Type: Text , Journal article
  • Relation: Fertility and Sterility Vol. 90, no. 2 (2008), p. 265-271
  • Full Text:
  • Reviewed:
  • Description: Objective: To review mathematical models used to determine sperm donor limits for infertility treatment and to consider the need to develop a new, internationally recognized and applicable model for calculating limits. Design: Literature review. Setting: Models for determining sperm donor limits were identified through bibliographic databases. Patient(s): Published models. Intervention(s): Variables used in the models were defined, evaluated, and assessed for relevancy and applicability. Main Outcome Measure(s): Relevance and applicability of model variables used to predict the number of consanguineous matings, probability of unwitting sibling mating and contribution to F (coefficient of inbreeding). Result(s): Models found to be outdated and inadequate for the present-day. Conclusion(s): Many countries have introduced limits to the number of offspring each anonymous sperm donor can father but these limits vary considerably. Published models for calculating sperm donor limits are in need of improvement and it is recommended that an enhanced, internationally applicable formula be developed for calculating acceptable limits. Moreover, it is recommended that further research be undertaken into the social and familial consequences of the revocation of sperm donor anonymity and the implications for the setting of sperm donor limits. © 2008 American Society for Reproductive Medicine.
  • Description: C1

Cardiovascular diseases and G-protein beta 3 subunit gene (GNB3) in the era of genomewide scans

- Tomaszewski, Maciej, Charchar, Fadi, Padmanabhan, Sandosh, Zukowska-Szczechowska, Ewa, Grzeszczak, Wladyslaw, Dominiczak, Anna

Relative survival after hospitalisation for hip fracture in older people in New South Wales, Australia

- Hindmarsh, Diane, Hayen, Andrew, Finch, Caroline, Close, Jacqueline

  • Authors: Hindmarsh, Diane , Hayen, Andrew , Finch, Caroline , Close, Jacqueline
  • Date: 2008
  • Type: Text , Journal article
  • Relation: Osteoporosis International Vol. , no. (2008), p. 1-9
  • Full Text:
  • Reviewed:
  • Description: Summary: Survival after hospitalisation for hip fracture by age group and sex relative to survival in the general population was assessed in people aged 65+. Men had double the risk of death compared with women to 1 year, but age effects lasted only to 3 months. Clinical outcomes need to be improved. Introduction: We assessed the relative survival of hospitalised fall-related hip fracture patients aged 65+ years leaving hospital in New South Wales, Australia, between July 2000 and December 2003. Method: We carried out a population-based study of all hospital separations for NSW residents with a principal diagnosis of hip fracture (ICD-10-AM S72.0 to S72.2) and first external cause of fall (ICD-10-AM codes W00 to W19), linked to NSW death data. A total of 16,836 cases were included. Relative survival 3 to 36 months post-admission by 10-year age groups and sex was calculated, using NSW life tables for 2002-2004. Relative excess risk was modelled using a generalised linear model with Poisson error structure, using the life table data. Results: One-year cumulative relative survival in 65- to 74-year-olds was 82% (men), 90% (women); in 85+-year-olds 65% (men), 80% (women). Men have a relative excess risk of death of 2.2 (95% CI 2.03-2.38) times that of women. Only 21% of deaths mention the hip fracture as contributing to death. Conclusion: There is a need to reduce the number of hip fractures and improve clinical outcomes for older people hospitalised with hip fractures. © 2008 International Osteoporosis Foundation and National Osteoporosis Foundation.
  • Description: C1
  • Description: 2003008189

Epidemiology of scalds in vulnerable groups in New South Wales, Australia, 1998/1999 to 2002/2003

- Boufous, Soufiane, Finch, Caroline

  • Authors: Boufous, Soufiane , Finch, Caroline
  • Date: 2005
  • Type: Text , Journal article
  • Relation: Journal of Burn Care & Research Vol. 26, no. 4 (2005), p. 320-326
  • Full Text: false
  • Reviewed:
  • Description: In this study, the recently introduced International Classification of Disease, 10th revision, code for hot tap water scalds was used to examine the epidemiology of these cases and other scalds injuries in children younger than 5 years of age and adults aged 65 years and older. Although the trunk was the most common area in which scalds occurred, young children were more likely to sustain head and neck scalds (15%, 95% confidence interval 10.8-18.3) because of hot tap water than older people (2%, 95% confidence interval 0.2-4.4). Hospital separation rates for hot water scalds decreased significantly during the study period in both boys ([chi]2 = 15.6, df = 1, P < .001) and girls ([chi]2 = 5.6, df = 1, P < .001) who were younger than 5 years of age, which might be attributable to the introduction of new standards regulating the provision of hot tap water to various buildings. The severity of scalds cases did not seem to be correlated with the length of hospital stay, which remained unchanged in both age groups.
  • Description: 2003005000

Whole genome survey of copy number variation in the spontaneously hypertensive rat

- Charchar, Fadi, Samani, Nilesh

Ageing and time : Multidisciplinary perspectives

- Guse, Ilonka

Functional data modelling approach for analysing and predicting trends in incidence rates-an application to falls injury

- Ullah, Shahid, Finch, Caroline

  • Authors: Ullah, Shahid , Finch, Caroline
  • Date: 2010
  • Type: Text , Journal article
  • Relation: Osteoporosis International Vol. 21, no. 12 (2010), p. 2125-2134
  • Relation: http://purl.org/au-research/grants/nhmrc/565900
  • Full Text:
  • Reviewed:
  • Description: Summary: Policy decisions about the allocation of current and future resources should be based on the most accurate predictions possible. A functional data analysis (FDA) approach improves the understanding of current trends and future incidence of injuries. FDA provides more valid and reliable long-term predictions than commonly used methods. Introduction: Accurate information about predicted future injury rates is needed to inform public health investment decisions. It is critical that such predictions derived from the best available statistical models to minimise possible error in future injury incidence rates. Methods: FDA approach was developed to improve long-term predictions but is yet to be widely applied to injury epidemiology or other epidemiological research. Using the specific example of modelling age-specific annual incidence of fall-related severe head injuries of older people during 1970-2004 and predicting rates up to 2024 in Finland, this paper explains the principles behind FDA and demonstrates their superiority in terms of prediction accuracy over the more commonly reported ordinary least squares (OLS) approach. Results: Application of the FDA approach shows that the incidence of fall-related severe head injuries would increase by 2.3-2.6-fold by 2024 compared to 2004. The FDA predictions had 55% less prediction error than traditional OLS predictions when compared to actual data. Conclusions: In summary, FDA provides more accurate predictions of long-term incidence trends than commonly used methods. The production of FDA prediction intervals for future injury incidence rates gives likely guidance as to the likely accuracy of these predictions. © 2010 International Osteoporosis Foundation and National Osteoporosis Foundation.