- Title
- Moxonidine increases uptake of oxidised low-density lipoprotein in cultured vascular smooth muscle cells and inhibits atherosclerosis in apolipoprotein E-deficient mice
- Creator
- Wang, Yutang; Nguyen, Dinh; Anesi, Jack; Alramahi, Ahmed; Witting, Paul; Chai, Zhonglin; Khan, Abdul; Kelly, Jason; Denton, Kate; Golledge, Jonathan
- Date
- 2023
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/193427
- Identifier
- vital:18186
- Identifier
-
https://doi.org/10.3390/ijms24043857
- Identifier
- ISSN:1661-6596 (ISSN)
- Abstract
- This study aimed to investigate the effect of the sympatholytic drug moxonidine on atherosclerosis. The effects of moxonidine on oxidised low-density lipoprotein (LDL) uptake, inflammatory gene expression and cellular migration were investigated in vitro in cultured vascular smooth muscle cells (VSMCs). The effect of moxonidine on atherosclerosis was measured by examining aortic arch Sudan IV staining and quantifying the intima-to-media ratio of the left common carotid artery in apolipoprotein E-deficient (ApoE
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Relation
- International Journal of Molecular Sciences Vol. 24, no. 4 (2023), p.; https://purl.org/au-research/grants/nhmrc/1062671
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- https://creativecommons.org/licenses/by/4.0/
- Rights
- Copyright © 2023 by the authors
- Rights
- Open Access
- Subject
- 3101 Biochemistry and cell biology; 3107 Microbiology; 3404 Medicinal and biomolecular chemistry; Atherosclerosis; Cell migration; Inflammation; Moxonidine
- Full Text
- Reviewed
- Funder
- This research was funded by the National Health and Medical Research Council of Australia, grant number 1062671. Dinh Tam Nguyen was supported by a George Collins Memorial Scholarship and an Australian Government Research Training Program (RTP) Stipend and Fee-Offset Scholarship through Federation University Australia. Jack Anesi was supported by a Fee-Offset Scholarship through Federation University Australia.
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