- Title
- The Interleukin-11/IL-11 receptor promotes glioblastoma survival and invasion under glucose-starved conditions through enhanced glutaminolysis
- Creator
- Stuart, Sarah; Bezawork-Geleta, Ayenachew; Areeb, Zammam; Gomez, Juliana; Tsui, Vanessa; Zulkifli, Ahmad; Paradiso, Lucia; Jones, Jordan; Nguyen, Hong; Putoczki, Tracy; Licciardi, Paul; Kannourakis, George; Morokoff, Andrew; Achuthan, Adrian; Luwor, Rodney
- Date
- 2023
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/193439
- Identifier
- vital:18184
- Identifier
-
https://doi.org/10.3390/ijms24043356
- Identifier
- ISSN:1661-6596 (ISSN)
- Abstract
- Glioblastoma cells adapt to changes in glucose availability through metabolic plasticity allowing for cell survival and continued progression in low-glucose concentrations. However, the regulatory cytokine networks that govern the ability to survive in glucose-starved conditions are not fully defined. In the present study, we define a critical role for the IL-11/IL-11R
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Relation
- International Journal of Molecular Sciences Vol. 24, no. 4 (2023), p.
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- https://creativecommons.org/licenses/by/4.0/
- Rights
- Published
- Rights
- Open Access
- Subject
- 3101 Biochemistry and cell biology; 3107 Microbiology; 3404 Medicinal and biomolecular chemistry; Glioblastoma; Glutaminolysis; IL-11; Invasion; Survival
- Full Text
- Reviewed
- Funder
- S.F.S. is a recipient of the International Foundation for Ethical Research Grant. A.B.-G. is a recipient of funding from the Rebecca L. Cooper Medical Research Foundation.
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