Fasting triglycerides are positively associated with cardiovascular mortality risk in people with diabetes
- Wang, Yutang, Fang, Yan, Magliano, Dianna, Charchar, Fadi, Sobey, Christopher, Drummond, Grant, Golledge, Jonathan
- Authors: Wang, Yutang , Fang, Yan , Magliano, Dianna , Charchar, Fadi , Sobey, Christopher , Drummond, Grant , Golledge, Jonathan
- Date: 2023
- Type: Text , Journal article
- Relation: Cardiovascular Research Vol. 119, no. 3 (2023), p. 826-834
- Relation: https://purl.org/au-research/grants/nhmrc/1062671
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- Description: Aims We investigated the association of fasting triglycerides with cardiovascular disease (CVD) mortality. Methods and results This cohort study included US adults from the National Health and Nutrition Examination Surveys from 1988 to 2014. CVD mortality outcomes were ascertained by linkage to the National Death Index records. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of triglycerides for CVD mortality. The cohort included 26 570 adult participants, among which 3978 had diabetes. People with higher triglycerides had a higher prevalence of diabetes at baseline. The cohort was followed up for a mean of 12.0 years with 1492 CVD deaths recorded. A 1-natural-log-unit higher triglyceride was associated with a 30% higher multivariate-adjusted risk of CVD mortality in participants with diabetes (HR, 1.30; 95% CI, 1.08–1.56) but not in those without diabetes (HR, 0.95; 95% CI, 0.83–1.07). In participants with diabetes, people with high triglycerides (200–499 mg/dL) had a 44% (HR, 1.44; 95% CI, 1.12–1.85) higher multivariate-adjusted risk of CVD mortality compared with those with normal triglycerides (<150 mg/dL). The findings remained significant when diabetes was defined by fasting glucose levels alone, or after further adjustment for the use of lipid-lowering medications, or after the exclusion of those who took lipid-lowering medications. Conclusion This study demonstrates that fasting triglycerides of
- Authors: Wang, Yutang , Fang, Yan , Magliano, Dianna , Charchar, Fadi , Sobey, Christopher , Drummond, Grant , Golledge, Jonathan
- Date: 2023
- Type: Text , Journal article
- Relation: Cardiovascular Research Vol. 119, no. 3 (2023), p. 826-834
- Relation: https://purl.org/au-research/grants/nhmrc/1062671
- Full Text:
- Reviewed:
- Description: Aims We investigated the association of fasting triglycerides with cardiovascular disease (CVD) mortality. Methods and results This cohort study included US adults from the National Health and Nutrition Examination Surveys from 1988 to 2014. CVD mortality outcomes were ascertained by linkage to the National Death Index records. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of triglycerides for CVD mortality. The cohort included 26 570 adult participants, among which 3978 had diabetes. People with higher triglycerides had a higher prevalence of diabetes at baseline. The cohort was followed up for a mean of 12.0 years with 1492 CVD deaths recorded. A 1-natural-log-unit higher triglyceride was associated with a 30% higher multivariate-adjusted risk of CVD mortality in participants with diabetes (HR, 1.30; 95% CI, 1.08–1.56) but not in those without diabetes (HR, 0.95; 95% CI, 0.83–1.07). In participants with diabetes, people with high triglycerides (200–499 mg/dL) had a 44% (HR, 1.44; 95% CI, 1.12–1.85) higher multivariate-adjusted risk of CVD mortality compared with those with normal triglycerides (<150 mg/dL). The findings remained significant when diabetes was defined by fasting glucose levels alone, or after further adjustment for the use of lipid-lowering medications, or after the exclusion of those who took lipid-lowering medications. Conclusion This study demonstrates that fasting triglycerides of
- Yang, Guang, Qian, Tingting, Sun, Hui, Xu, Qun, Hou, Xujuan, Hu, Wenqi, Zhang, Guang, Fang, Yan, Song, David, Chai, Zhonglin, Magliano, Dianna, Golledge, Jonathan, Wang, Yutang
- Authors: Yang, Guang , Qian, Tingting , Sun, Hui , Xu, Qun , Hou, Xujuan , Hu, Wenqi , Zhang, Guang , Fang, Yan , Song, David , Chai, Zhonglin , Magliano, Dianna , Golledge, Jonathan , Wang, Yutang
- Date: 2022
- Type: Text , Journal article
- Relation: Diabetes epidemiology and management Vol. 6, no. (2022), p. 100050
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- Description: •The LDL-C reference interval was 1.48–3.77 mmol/L in Chinese adults.•Hypocholesterolemia was associated with a 57% higher risk for diabetes.•Hypercholesterolemia was associated with a 29% higher risk for diabetes. This study aimed to investigate whether both high and low levels of low-density lipoprotein cholesterol (LDL-C), i.e., hypercholesterolemia and hypocholesterolemia, were associated with diabetes in Chinese adults. This cross-sectional study included 22,557 Chinese adults. The LDL-C reference interval was determined from a healthy sub-cohort. Associations between hypocholesterolemia or hypercholesterolemia with diabetes were analyzed using binary logistic regression. The LDL-C reference interval was 1.48–3.77 mmol/L (57.23–145.78 mg/dL). Therefore, hypocholesterolemia, normocholesterolemia, and hypercholesterolemia were defined as an LDL-C concentration of <1.48, 1.48–3.77, and >3.77 mmol/L, respectively. Prevalence of diabetes was higher in people with hypocholesterolemia or hypercholesterolemia than that in people with normocholesterolemia. Hypocholesterolemia was associated with an increased multivariable-adjusted risk for diabetes diagnosis (odds ratio, 1.57 95% confidence interval, 1.18–2.08), and so was hypercholesterolemia (odds ratio, 1.29 95% confidence interval, 1.10–1.51). The results remained significant after exclusion of those who took lipid-lowering drugs from the analysis. This study demonstrated that both low and high levels of LDL-C were associated with a higher risk of diabetes diagnosis. Patients with either high or low LDL-C may need to be closely monitored for the risk of diabetes .
Tree nut consumption is associated with a lower risk of hyperestrogenism in men
- Authors: Wang, Yutang , Fang, Yan
- Date: 2022
- Type: Text , Journal article
- Relation: Nutrition Research Vol. 98, no. (2022), p. 1-8
- Relation: https://purl.org/au-research/grants/nhmrc/1062671
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- Description: Hyperestrogenism may affect 2% to 8% of men globally. Previous studies indicate that tree nut consumption is associated with sex hormones in women. Whether this is the case in men remains unknown. This study hypothesized that consumption of tree nuts was inversely associated with circulating estradiol and prevalence of hyperestrogenism in men. This cross-sectional study included 3340 men aged ≥20 years from the US National Health and Nutrition Examination Survey from 2013 to 2016. Associations of tree nut consumption with circulating estradiol and prevalence of hyperestrogenism were assessed using weighted linear regression and binary logistic regression, respectively. Among the 3340 men, 207 consumed tree nuts. The mean usual intake of tree nuts among tree nut consumers was 34.2 g/d. Amounts of usual intake of tree nuts were inversely associated with bioavailable estradiol (β = -0.032, P = .037) after adjustment for all confounders. Usual intake of tree nuts of ≥ 30 g/d (vs <30 g/d) or ≥42.52 g/d (vs <42.52 g/d) was associated with a 24% or 7% lower multivariate-adjusted risk of hyperestrogenism, respectively. Further analyses showed that usual intake of tree nuts was positively associated with circulating folate, and the latter was inversely associated with circulating estradiol. In conclusion, higher tree nut consumption was independently associated with lower circulating levels of bioavailable estradiol and a lower risk of hyperestrogenism in men. Further research is needed to verify the effectiveness of using tree nuts to treat hyperestrogenism in men. © 2022
- Authors: Wang, Yutang , Fang, Yan
- Date: 2022
- Type: Text , Journal article
- Relation: Nutrition Research Vol. 98, no. (2022), p. 1-8
- Relation: https://purl.org/au-research/grants/nhmrc/1062671
- Full Text:
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- Description: Hyperestrogenism may affect 2% to 8% of men globally. Previous studies indicate that tree nut consumption is associated with sex hormones in women. Whether this is the case in men remains unknown. This study hypothesized that consumption of tree nuts was inversely associated with circulating estradiol and prevalence of hyperestrogenism in men. This cross-sectional study included 3340 men aged ≥20 years from the US National Health and Nutrition Examination Survey from 2013 to 2016. Associations of tree nut consumption with circulating estradiol and prevalence of hyperestrogenism were assessed using weighted linear regression and binary logistic regression, respectively. Among the 3340 men, 207 consumed tree nuts. The mean usual intake of tree nuts among tree nut consumers was 34.2 g/d. Amounts of usual intake of tree nuts were inversely associated with bioavailable estradiol (β = -0.032, P = .037) after adjustment for all confounders. Usual intake of tree nuts of ≥ 30 g/d (vs <30 g/d) or ≥42.52 g/d (vs <42.52 g/d) was associated with a 24% or 7% lower multivariate-adjusted risk of hyperestrogenism, respectively. Further analyses showed that usual intake of tree nuts was positively associated with circulating folate, and the latter was inversely associated with circulating estradiol. In conclusion, higher tree nut consumption was independently associated with lower circulating levels of bioavailable estradiol and a lower risk of hyperestrogenism in men. Further research is needed to verify the effectiveness of using tree nuts to treat hyperestrogenism in men. © 2022
Hypouricemia is a risk factor for diabetes in Chinese adults
- Wang, Yutang, Shao, Yanan, Qian, Tingting, Sun, Hui, Xu, Qun, Hou, Xujuan, Hu, Wenqi, Zhang, Guang, Song, David, Fang, Yan, Magliano, Dianna, Witting, Paul, Golledge, Jonathan, Yang, Guang
- Authors: Wang, Yutang , Shao, Yanan , Qian, Tingting , Sun, Hui , Xu, Qun , Hou, Xujuan , Hu, Wenqi , Zhang, Guang , Song, David , Fang, Yan , Magliano, Dianna , Witting, Paul , Golledge, Jonathan , Yang, Guang
- Date: 2022
- Type: Text , Journal article
- Relation: Obesity Medicine Vol. 31, no. (2022), p.
- Relation: https://purl.org/au-research/grants/nhmrc/1062671
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- Description: Aims: It is unknown whether low serum uric acid (hypouricemia) is associated with diabetes diagnosis. This study aimed to investigate this association in Chinese adults. Methods: This cross-sectional study included 22,546 Chinese adults. The reference interval for serum uric acid was determined in a sub-group of healthy individuals. The association between hypouricemia and diabetes was analyzed using binary logistic regression. Results: The serum uric acid reference intervals were 3.78–8.31 mg/dL for males and 2.76–6.24 mg/dL for females. Hypouricemia was defined as serum uric acid concentration <3.78 mg/dL for males and <2.76 mg/dL for females. Hypouricemia was associated with an increased likelihood of diabetes diagnosis in both unadjusted (odds ratio [OR], 2.23; 95% confidence interval [CI], 1.78–2.79) and risk factor adjusted (OR, 2.67; 95% CI, 2.08–3.43) analyses. In a sub-group analysis, hypouricemia was significantly independently associated with an increased likelihood of diabetes diagnosis in males but not females. Conclusion: This study suggests that hypouricemia is independently associated with an increased risk of diabetes diagnosis. The findings should be validated in prospective cohort studies. © 2022 Elsevier Ltd
- Authors: Wang, Yutang , Shao, Yanan , Qian, Tingting , Sun, Hui , Xu, Qun , Hou, Xujuan , Hu, Wenqi , Zhang, Guang , Song, David , Fang, Yan , Magliano, Dianna , Witting, Paul , Golledge, Jonathan , Yang, Guang
- Date: 2022
- Type: Text , Journal article
- Relation: Obesity Medicine Vol. 31, no. (2022), p.
- Relation: https://purl.org/au-research/grants/nhmrc/1062671
- Full Text:
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- Description: Aims: It is unknown whether low serum uric acid (hypouricemia) is associated with diabetes diagnosis. This study aimed to investigate this association in Chinese adults. Methods: This cross-sectional study included 22,546 Chinese adults. The reference interval for serum uric acid was determined in a sub-group of healthy individuals. The association between hypouricemia and diabetes was analyzed using binary logistic regression. Results: The serum uric acid reference intervals were 3.78–8.31 mg/dL for males and 2.76–6.24 mg/dL for females. Hypouricemia was defined as serum uric acid concentration <3.78 mg/dL for males and <2.76 mg/dL for females. Hypouricemia was associated with an increased likelihood of diabetes diagnosis in both unadjusted (odds ratio [OR], 2.23; 95% confidence interval [CI], 1.78–2.79) and risk factor adjusted (OR, 2.67; 95% CI, 2.08–3.43) analyses. In a sub-group analysis, hypouricemia was significantly independently associated with an increased likelihood of diabetes diagnosis in males but not females. Conclusion: This study suggests that hypouricemia is independently associated with an increased risk of diabetes diagnosis. The findings should be validated in prospective cohort studies. © 2022 Elsevier Ltd
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