Calibration and validation of a sand model considering the effects of wave-induced principal stress axes rotation
- Authors: Liu, Peng , Wang, Zhongtao , Li, Xinzhong , Chan, Andrew
- Date: 2015
- Type: Text , Journal article
- Relation: Acta Oceanologica Sinica Vol. 34, no. 7 (2015), p. 105-115
- Full Text: false
- Reviewed:
- Description: Principal stress axes rotation influences the stress-strain behavior of sand under wave loading. A constitutive model for sand, which considers principal stress orientation and is based on generalized plasticity theory, is proposed. The new model, which employs stress invariants and a discrete memory factor during reloading, is original because it quantifies model parameters using experimental data. Four sets of hollow torsion experiments were conducted to calibrate the parameters and predict the capability of the proposed model, which describes the effects of principal stress orientation on the behavior of sand. The results prove the effectiveness of the proposed calibration method. © 2015, The Chinese Society of Oceanography and Springer-Verlag Berlin Heidelberg.
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
- Authors: Chambers, John , Zhang, Weihua , Sehmi, Joban , Li, Xinzhong , Wass, Mark N , van der Harst, Pim , Holm, Hilma , Sanna, Serena , Kavousi, Maryam , Charchar, Fadi
- Date: 2011
- Type: Text , Journal article
- Relation: Nature genetics Vol. 43, no. 11 (2011), p. 1131-1138
- Full Text: false
- Reviewed:
- Description: Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10−8 to P = 10−190). We used functional genomic approaches including metabonomic profiling and gene expression analyses to identify probable candidate genes at these regions. We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827). Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function. 137 authors