Ever and cumulative occupational exposure and lung function decline in longitudinal population-based studies : a systematic review and meta-analysis
- Rabbani, Golam, Nimmi, Naima, Benke, Geza, Dharmage, Shyamali, Bui, Dinh, Sim, Malcolm, Abramson, Michael, Alif, Sheikh
- Authors: Rabbani, Golam , Nimmi, Naima , Benke, Geza , Dharmage, Shyamali , Bui, Dinh , Sim, Malcolm , Abramson, Michael , Alif, Sheikh
- Date: 2022
- Type: Text , Journal article , Review
- Relation: Occupational and Environmental Medicine Vol. 80, no. 1 (2022), p. 51-60
- Full Text:
- Reviewed:
- Description: Objectives Adverse occupational exposures can accelerate age-related lung function decline. Some longitudinal population-based studies have investigated this association. This study aims to examine this association using findings reported by longitudinal population-based studies. Methods Ovid Medline, PubMed, Embase, and Web of Science were searched using keywords and text words related to occupational exposures and lung function and 12 longitudinal population-based studies were identified using predefined inclusion criteria. The quality of the studies was assessed using the Newcastle-Ottawa Scale. Lung function decline was defined as annual loss of forced expiratory volume in 1 s (FEV 1), forced vital capacity (FVC) or the ratio (FEV 1 /FVC). Fixed and random-effects meta-analyses were conducted to calculate pooled estimates for ever and cumulative exposures. Heterogeneity was assessed using the I 2 test, and publication bias was evaluated using funnel plots. Results Ever exposures to gases/fumes, vapours, gases, dusts, fumes (VGDF) and aromatic solvents were significantly associated with FEV 1 decline in meta-analyses. Cumulative exposures for these three occupational agents observed a similar trend of FEV 1 decline. Ever exposures to fungicides and cumulative exposures to biological dust, fungicides and insecticides were associated with FEV 1 decline in fixed-effect models only. No statistically significant association was observed between mineral dust, herbicides and metals and FEV 1 decline in meta-analyses. Conclusion Pooled estimates from the longitudinal population-based studies have provided evidence that occupational exposures are associated with FEV 1 decline. Specific exposure control and respiratory health surveillance are required to protect the lung health of the workers. © 2023 Author(s). Published by BMJ.
- Authors: Rabbani, Golam , Nimmi, Naima , Benke, Geza , Dharmage, Shyamali , Bui, Dinh , Sim, Malcolm , Abramson, Michael , Alif, Sheikh
- Date: 2022
- Type: Text , Journal article , Review
- Relation: Occupational and Environmental Medicine Vol. 80, no. 1 (2022), p. 51-60
- Full Text:
- Reviewed:
- Description: Objectives Adverse occupational exposures can accelerate age-related lung function decline. Some longitudinal population-based studies have investigated this association. This study aims to examine this association using findings reported by longitudinal population-based studies. Methods Ovid Medline, PubMed, Embase, and Web of Science were searched using keywords and text words related to occupational exposures and lung function and 12 longitudinal population-based studies were identified using predefined inclusion criteria. The quality of the studies was assessed using the Newcastle-Ottawa Scale. Lung function decline was defined as annual loss of forced expiratory volume in 1 s (FEV 1), forced vital capacity (FVC) or the ratio (FEV 1 /FVC). Fixed and random-effects meta-analyses were conducted to calculate pooled estimates for ever and cumulative exposures. Heterogeneity was assessed using the I 2 test, and publication bias was evaluated using funnel plots. Results Ever exposures to gases/fumes, vapours, gases, dusts, fumes (VGDF) and aromatic solvents were significantly associated with FEV 1 decline in meta-analyses. Cumulative exposures for these three occupational agents observed a similar trend of FEV 1 decline. Ever exposures to fungicides and cumulative exposures to biological dust, fungicides and insecticides were associated with FEV 1 decline in fixed-effect models only. No statistically significant association was observed between mineral dust, herbicides and metals and FEV 1 decline in meta-analyses. Conclusion Pooled estimates from the longitudinal population-based studies have provided evidence that occupational exposures are associated with FEV 1 decline. Specific exposure control and respiratory health surveillance are required to protect the lung health of the workers. © 2023 Author(s). Published by BMJ.
Exploration of associations between occupational exposures and current adult eczema
- Lopez, Diego, Alif, Sheikh, Dharmage, Shyamali, Lodge, Caroline, Bui, Dinh, Le Moual, Nicole, Waidyatillake, Nilakshi, Su, John, Abramson, Michael, Walters, E., Hamilton, Garun, Bowatte, Gayan, Erbas, Bircan, Benke, Geza, Perret, Jennifer, Lowe, Adrian
- Authors: Lopez, Diego , Alif, Sheikh , Dharmage, Shyamali , Lodge, Caroline , Bui, Dinh , Le Moual, Nicole , Waidyatillake, Nilakshi , Su, John , Abramson, Michael , Walters, E. , Hamilton, Garun , Bowatte, Gayan , Erbas, Bircan , Benke, Geza , Perret, Jennifer , Lowe, Adrian
- Date: 2023
- Type: Text , Journal article
- Relation: Occupational and Environmental Medicine Vol. 80, no. 10 (2023), p. 564-571
- Full Text: false
- Reviewed:
- Description: Objectives There is a scarcity of evidence on occupational exposures that may increase eczema in adults. We aimed to investigate potential associations between occupational exposures and eczema in middle-aged adults. Methods A lifetime work history calendar was collected from the Tasmanian Longitudinal Health Study participants when they were at age 53. Their work history was collated with the occupational asthma-specific job exposure matrix to define ever-exposure and cumulative exposure unit-years since no eczema job exposure matrix is available. Eczema was determined using the report of flexural rash that was coming and going for at least 6 months in the last 12 months. Skin prick tests were used to further subgroup eczema and atopic eczema (AE) or non-AE (NAE). Logistic and multinomial regression models were used to investigate the associations. Results Eczema prevalence was 9.1%. Current occupational exposure to animals (adjusted OR, aOR=3.06 (95% CI 1.43 to 6.58)), storage mites (aOR=2.96 (95% CI 1.38 to 6.34)) and endotoxin (aOR=1.95 (95% CI 1.04 to 3.64)) were associated with increased risk of current eczema. Furthermore, increased odds of NAE were associated with current exposure to animals (aOR=5.60 (95% CI 1.45 to 21.7)) and storage mites (aOR=5.63 (95% CI 1.45 to 21.9)). Current exposures to isocyanates (aOR=5.27 (95% CI 1.17 to 23.7)) and acrylates (aOR=8.41 (95% CI 1.60 to 44.3)) were associated with AE. There was no evidence of associations between cumulative exposures and eczema prevalence. Cumulative exposure to metalworking fluids (aOR=1.10 (95% CI 1.01 to 1.22)) was associated with NAE and acrylates (aOR=1.24 (95% CI 1.04 to 1.46)) with AE. Conclusions In this exploratory assessment, multiple occupational exposures were associated with current eczema in middle-aged adults. Raising awareness and limiting these exposures during an individual's productive working life will likely have various health benefits, including reducing eczema prevalence. © Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.
- «
- ‹
- 1
- ›
- »