Incidence, mortality, and factors associated with primary postpartum haemorrhage following in-hospital births in northwest Ethiopia
- Tiruneh, Bewket, Fooladi, Ensieh, McLelland, Gayle, Plummer, Virginia
- Authors: Tiruneh, Bewket , Fooladi, Ensieh , McLelland, Gayle , Plummer, Virginia
- Date: 2022
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 17, no. 4 (2022), p.
- Full Text:
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- Description: Background Of the 1010 reported maternal deaths in 2018, just over 65% occurred in hospitals in Ethiopia. However, there is a lack of standardised data about the contributing factors. This study aimed to investigate the incidence, mortality, and factors associated with primary postpartum haemorrhage following in-hospital births in northwest Ethiopia. Methods A retrospective cohort design was used; an audit of 1060 maternity care logbooks of adult women post-partum at Felege Hiwot Referral Hospital and University of Gondar Comprehensive Specialized Hospital. The data were abstracted between December 2018 and May 2019 using a systematic random sampling technique. We used the Facility Based Maternal Death Abstraction Form containing sociodemographic characteristics, women’s medical history, and partographs. Primary postpartum haemorrhage was defined as the estimated blood loss recorded by the staff greater or equal to 500 ml for vaginal births and 1000 ml for caesarean section births, or the medical doctor diagnosis and recording of the woman as having primary postpartum haemorrhage. The data analysis was undertaken using Stata version 15. Variables with P 0.10 for significance were selected to run multivariable logistic analyses. Variables that had associations with primary postpartum haemorrhage were identified based on the odds ratio, with 95% confidence interval (CI) and P-value less than 0.05. Results The incidence of primary postpartum haemorrhage in the hospitals was 8.8% (95% CI: 7.2, 10.6). Of these, there were 7.4% (95% CI: 2.1, 13.3) maternal deaths. Eight predictor variables were found to be independently associated with primary postpartum haemorrhage, including age 35 years (AOR: 2.20; 95% CI: 1.08, 4.46; P = 0.03), longer than 24 hours duration of labour (AOR: 7.18; 95% CI: 2.73, 18.90; P = 0.01), vaginal or cervical lacerations (AOR: 4.95; 95% CI: 2.49, 9.86; P = 0.01), instrumental (forceps or vacuum)-assisted birth (AOR: 2.92; 95% CI: 1.25, 6.81; P = 0.01), retained placenta (AOR: 21.83; 95% CI: 6.33, 75.20; P = 0.01), antepartum haemorrhage in recent pregnancy (AOR: 6.90; 95% CI: 3.43, 13. 84; p = 0.01), women in labour referred from primary health centres (AOR: 2.48; 95% CI: 1.39, 4.42; P = 0.02), and births managed by medical interns (AOR: 2.90; 95% CI: 1.55, 5.37; P = 0.01). Conclusion We found that while the incidence of primary postpartum haemorrhage appeared to be lower than in other studies in Africa the associated maternal mortality was higher. Although most factors associated with primary postpartum haemorrhage were consistent with those identified in the literature, two additional specific factors, were found to be prevalent among women in Ethiopia; the factors were referred women in labour from primary health facilities and births managed by medical interns. Maternal healthcare providers in these hospitals require training on the management of a birthing emergency. © 2022 Tiruneh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Authors: Tiruneh, Bewket , Fooladi, Ensieh , McLelland, Gayle , Plummer, Virginia
- Date: 2022
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 17, no. 4 (2022), p.
- Full Text:
- Reviewed:
- Description: Background Of the 1010 reported maternal deaths in 2018, just over 65% occurred in hospitals in Ethiopia. However, there is a lack of standardised data about the contributing factors. This study aimed to investigate the incidence, mortality, and factors associated with primary postpartum haemorrhage following in-hospital births in northwest Ethiopia. Methods A retrospective cohort design was used; an audit of 1060 maternity care logbooks of adult women post-partum at Felege Hiwot Referral Hospital and University of Gondar Comprehensive Specialized Hospital. The data were abstracted between December 2018 and May 2019 using a systematic random sampling technique. We used the Facility Based Maternal Death Abstraction Form containing sociodemographic characteristics, women’s medical history, and partographs. Primary postpartum haemorrhage was defined as the estimated blood loss recorded by the staff greater or equal to 500 ml for vaginal births and 1000 ml for caesarean section births, or the medical doctor diagnosis and recording of the woman as having primary postpartum haemorrhage. The data analysis was undertaken using Stata version 15. Variables with P 0.10 for significance were selected to run multivariable logistic analyses. Variables that had associations with primary postpartum haemorrhage were identified based on the odds ratio, with 95% confidence interval (CI) and P-value less than 0.05. Results The incidence of primary postpartum haemorrhage in the hospitals was 8.8% (95% CI: 7.2, 10.6). Of these, there were 7.4% (95% CI: 2.1, 13.3) maternal deaths. Eight predictor variables were found to be independently associated with primary postpartum haemorrhage, including age 35 years (AOR: 2.20; 95% CI: 1.08, 4.46; P = 0.03), longer than 24 hours duration of labour (AOR: 7.18; 95% CI: 2.73, 18.90; P = 0.01), vaginal or cervical lacerations (AOR: 4.95; 95% CI: 2.49, 9.86; P = 0.01), instrumental (forceps or vacuum)-assisted birth (AOR: 2.92; 95% CI: 1.25, 6.81; P = 0.01), retained placenta (AOR: 21.83; 95% CI: 6.33, 75.20; P = 0.01), antepartum haemorrhage in recent pregnancy (AOR: 6.90; 95% CI: 3.43, 13. 84; p = 0.01), women in labour referred from primary health centres (AOR: 2.48; 95% CI: 1.39, 4.42; P = 0.02), and births managed by medical interns (AOR: 2.90; 95% CI: 1.55, 5.37; P = 0.01). Conclusion We found that while the incidence of primary postpartum haemorrhage appeared to be lower than in other studies in Africa the associated maternal mortality was higher. Although most factors associated with primary postpartum haemorrhage were consistent with those identified in the literature, two additional specific factors, were found to be prevalent among women in Ethiopia; the factors were referred women in labour from primary health facilities and births managed by medical interns. Maternal healthcare providers in these hospitals require training on the management of a birthing emergency. © 2022 Tiruneh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Morally excused but socially excluded : denying agency through the defense of mental impairment
- De Vel-Palumbo, Melissa, Ferguson, Rose, Schein, Chelsea, Chang, Melissa, Bastian, Brock
- Authors: De Vel-Palumbo, Melissa , Ferguson, Rose , Schein, Chelsea , Chang, Melissa , Bastian, Brock
- Date: 2022
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 17, no. 7 July (2022), p.
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- Description: Defendants can deny they have agency, and thus responsibility, for a crime by using a defense of mental impairment. We argue that although this strategy may help defendants evade blame, it may carry longer-term social costs, as lay people's perceptions of a person's agency might determine some of the moral rights they grant them. Three randomized between-group experiments (N = 1601) used online vignettes to examine lay perceptions of a hypothetical defendant using a defense of mental impairment (versus a guilty plea). We find that using a defense of mental impairment significantly reduces responsibility, blame, and punitiveness relative to a guilty plea, and these judgments are mediated by perceptions of reduced moral agency. However, after serving their respective sentences, those using the defense are sometimes conferred fewer rights, as reduced agency corresponds to an increase in perceived dangerousness. Our findings were found to be robust across different types of mental impairment, offences/sentences, and using both manipulated and measured agency. The findings have implications for defendants claiming reduced agency through legal defenses, as well as for the broader study of moral rights and mind perception. © 2022 de Vel-Palumbo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Authors: De Vel-Palumbo, Melissa , Ferguson, Rose , Schein, Chelsea , Chang, Melissa , Bastian, Brock
- Date: 2022
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 17, no. 7 July (2022), p.
- Full Text:
- Reviewed:
- Description: Defendants can deny they have agency, and thus responsibility, for a crime by using a defense of mental impairment. We argue that although this strategy may help defendants evade blame, it may carry longer-term social costs, as lay people's perceptions of a person's agency might determine some of the moral rights they grant them. Three randomized between-group experiments (N = 1601) used online vignettes to examine lay perceptions of a hypothetical defendant using a defense of mental impairment (versus a guilty plea). We find that using a defense of mental impairment significantly reduces responsibility, blame, and punitiveness relative to a guilty plea, and these judgments are mediated by perceptions of reduced moral agency. However, after serving their respective sentences, those using the defense are sometimes conferred fewer rights, as reduced agency corresponds to an increase in perceived dangerousness. Our findings were found to be robust across different types of mental impairment, offences/sentences, and using both manipulated and measured agency. The findings have implications for defendants claiming reduced agency through legal defenses, as well as for the broader study of moral rights and mind perception. © 2022 de Vel-Palumbo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
An exploration of trolling behaviours in Australian adolescents : an online survey
- Marrington, Jessica, March, Evita, Murray, Sarah, Jeffries, Carla, Machin, Tanya, March, Sonja
- Authors: Marrington, Jessica , March, Evita , Murray, Sarah , Jeffries, Carla , Machin, Tanya , March, Sonja
- Date: 2023
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 18, no. 4 April (2023), p.
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- Description: To understand why people “troll” (i.e., engage in disruptive online behaviour intended to provoke and distress for one’s own amusement), researchers have explored a range of individual differences. These studies have primarily been conducted in adult samples, despite adolescents being a particularly vulnerable group with regards to both being trolled and trolling others. In this study we aimed to (1) explore Australian adolescents’ experiences of trolling, and (2) replicate adult research that has constructed a psychological profile of the Internet troll by examining the utility of personality traits (psychopathy and sadism), self-esteem, empathy (cognitive and affective), and social rewards (negative social potency) to predict adolescents’ trolling behaviours. A sample of 157 Australian adolescents (40.8% male, 58% female, 0.6% non-binary) aged 13–18 years (M = 15.58, SD = 1.71) completed the Global Assessment of Internet Trolling-Revised, Adolescent Measure of Empathy and Sympathy, Rosenberg Self-Esteem Scale, Youth Psychopathy Traits Inventory-Short Version, Social Rewards Questionnaire, Short Sadistic Impulse Scale, and a series of questions related to the experience of trolling. Results showed in the past year, 24.2% of Australian adolescents reported being trolled and 13.4% reported having trolled others. Gender, psychopathy, sadism, self-esteem, cognitive empathy, affective empathy, and “negative social potency” (i.e., enjoyment of antisocial rewards) combined, explained 30.7% of variance in adolescents’ trolling behaviours (p < .001). When accounting for shared variance, gender (male), high psychopathy, and high negative social potency were significant predictors of trolling, aligning with findings of adult samples. Contrary to adult samples, sadism was not a unique predictor of adolescents’ trolling. For adolescents, the variance in trolling explained by sadism was nonsignificant when controlling for negative social potency. These similarities, and differences, in predictors of trolling across adult and adolescent samples may play a critical role in the development of targeted interventions to prevent or manage trolling. © 2023 Marrington et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Authors: Marrington, Jessica , March, Evita , Murray, Sarah , Jeffries, Carla , Machin, Tanya , March, Sonja
- Date: 2023
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 18, no. 4 April (2023), p.
- Full Text:
- Reviewed:
- Description: To understand why people “troll” (i.e., engage in disruptive online behaviour intended to provoke and distress for one’s own amusement), researchers have explored a range of individual differences. These studies have primarily been conducted in adult samples, despite adolescents being a particularly vulnerable group with regards to both being trolled and trolling others. In this study we aimed to (1) explore Australian adolescents’ experiences of trolling, and (2) replicate adult research that has constructed a psychological profile of the Internet troll by examining the utility of personality traits (psychopathy and sadism), self-esteem, empathy (cognitive and affective), and social rewards (negative social potency) to predict adolescents’ trolling behaviours. A sample of 157 Australian adolescents (40.8% male, 58% female, 0.6% non-binary) aged 13–18 years (M = 15.58, SD = 1.71) completed the Global Assessment of Internet Trolling-Revised, Adolescent Measure of Empathy and Sympathy, Rosenberg Self-Esteem Scale, Youth Psychopathy Traits Inventory-Short Version, Social Rewards Questionnaire, Short Sadistic Impulse Scale, and a series of questions related to the experience of trolling. Results showed in the past year, 24.2% of Australian adolescents reported being trolled and 13.4% reported having trolled others. Gender, psychopathy, sadism, self-esteem, cognitive empathy, affective empathy, and “negative social potency” (i.e., enjoyment of antisocial rewards) combined, explained 30.7% of variance in adolescents’ trolling behaviours (p < .001). When accounting for shared variance, gender (male), high psychopathy, and high negative social potency were significant predictors of trolling, aligning with findings of adult samples. Contrary to adult samples, sadism was not a unique predictor of adolescents’ trolling. For adolescents, the variance in trolling explained by sadism was nonsignificant when controlling for negative social potency. These similarities, and differences, in predictors of trolling across adult and adolescent samples may play a critical role in the development of targeted interventions to prevent or manage trolling. © 2023 Marrington et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Exploring sensory, motor, and pain responses as potential side or therapeutic effects of sub-2 mA, 400 Hz transcranial pulsed current stimulation
- Jaberzadeh, Shapour, Zoghi, Maryam
- Authors: Jaberzadeh, Shapour , Zoghi, Maryam
- Date: 2023
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 18, no. 12 December (2023), p.
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- Description: Background Various brain stimulation devices capable of generating high-frequency currents are readily available. However, our comprehension of the potential side or therapeutic effects associated with high-frequency transcranial pulsed current stimulation (tPCS), particularly concerning the new 400 Hz tPCS device, AscenZ-IV Stimulator, developed by AscenZion Neuromodulation Co. Pte. Ltd. in Singapore, remains incomplete. Objective This study examines preliminary parameters for the safe and comfortable application of 400 Hz tPCS at intensities below 2 mA. Methods In a cross-sectional study, 45 healthy participants underwent sub-2 mA 400 Hz tPCS to assess sensory, motor, and pain thresholds on the dominant side. Study 1 (N = 15) targeted the primary motor cortex of the right-hand area, while study 2 (N = 30) focused on the back of the right forearm. Results Study one showed that increasing the current intensity gradually resulted in no responses at sub-0.3 mA levels, but higher intensities (p < 0.001) induced sensory perception and pain responses. Study two replicated these findings and additionally induced motor responses along with the sensory and pain responses. Conclusion Despite the theoretical classification of tPCS as a subsensory level of stimulation, and the expectation that individuals receiving this type of current should not typically feel its application on the body, this high-frequency tPCS device generates different levels of stimulation due to the physiological phenomenon known as temporal summation. These novel levels of stimulation could be viewed as either potential “side-effects” of high frequency tPCS or as additional “therapeutic benefits”. This dual capacity may position the device as one that generates both neuromodulatory and neurostimulatory currents. Comprehensive comprehension of this is vital for the development of therapeutic protocols that incorporate high-frequency tPCS. Copyright: © 2023 Jaberzadeh, Zoghi. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Authors: Jaberzadeh, Shapour , Zoghi, Maryam
- Date: 2023
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 18, no. 12 December (2023), p.
- Full Text:
- Reviewed:
- Description: Background Various brain stimulation devices capable of generating high-frequency currents are readily available. However, our comprehension of the potential side or therapeutic effects associated with high-frequency transcranial pulsed current stimulation (tPCS), particularly concerning the new 400 Hz tPCS device, AscenZ-IV Stimulator, developed by AscenZion Neuromodulation Co. Pte. Ltd. in Singapore, remains incomplete. Objective This study examines preliminary parameters for the safe and comfortable application of 400 Hz tPCS at intensities below 2 mA. Methods In a cross-sectional study, 45 healthy participants underwent sub-2 mA 400 Hz tPCS to assess sensory, motor, and pain thresholds on the dominant side. Study 1 (N = 15) targeted the primary motor cortex of the right-hand area, while study 2 (N = 30) focused on the back of the right forearm. Results Study one showed that increasing the current intensity gradually resulted in no responses at sub-0.3 mA levels, but higher intensities (p < 0.001) induced sensory perception and pain responses. Study two replicated these findings and additionally induced motor responses along with the sensory and pain responses. Conclusion Despite the theoretical classification of tPCS as a subsensory level of stimulation, and the expectation that individuals receiving this type of current should not typically feel its application on the body, this high-frequency tPCS device generates different levels of stimulation due to the physiological phenomenon known as temporal summation. These novel levels of stimulation could be viewed as either potential “side-effects” of high frequency tPCS or as additional “therapeutic benefits”. This dual capacity may position the device as one that generates both neuromodulatory and neurostimulatory currents. Comprehensive comprehension of this is vital for the development of therapeutic protocols that incorporate high-frequency tPCS. Copyright: © 2023 Jaberzadeh, Zoghi. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Impact of smoking status and chronic obstructive pulmonary disease on pulmonary complications post lung cancer surgery
- Jeganathan, Vishnu, Knight, Simon, Bricknell, Matthew, Ridgers, Anna, Wong, Raymond, Brazzale, Danny, Ruehland, Warren, Rahman, Muhammad Aziz, Leong, Tracy, McDonald, Christine
- Authors: Jeganathan, Vishnu , Knight, Simon , Bricknell, Matthew , Ridgers, Anna , Wong, Raymond , Brazzale, Danny , Ruehland, Warren , Rahman, Muhammad Aziz , Leong, Tracy , McDonald, Christine
- Date: 2022
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 17, no. 3 March (2022), p.
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- Description: Introduction Smoking and chronic obstructive pulmonary disease (COPD) are associated with an increased risk of post-operative pulmonary complications (PPCs) following lung cancer resection. It remains unclear whether smoking cessation reduces this risk. Methods Retrospective review of a large, prospectively collected database of over 1000 consecutive resections for lung cancer in a quaternary lung cancer centre over a 23-year period. Results One thousand and thirteen patients underwent curative-intent lobectomy or pneumonectomy between 1995 and 2018. Three hundred and sixty-two patients (36%) were ex-smokers, 314 (31%) were current smokers and 111 (11%) were never smokers. A pre-operative diagnosis of COPD was present in 57% of current smokers, 57% of ex-smokers and 20% of never smokers. Just over 25% of patients experienced a PPC. PPCs were more frequent in current smokers compared to never smokers (27% vs 17%, p = 0.036), however, no difference was seen between current and ex-smokers (p = 0.412) or between never and ex-smokers (p = 0.113). Those with a diagnosis of COPD, independent of smoking status, had a higher frequency of both PPCs (65% vs 35%, p<0.01) and overall complications (60% vs 40%, p<0.01) as well as a longer length of hospital stay (10 vs 9 days, p<0.01). Conclusion Smoking and COPD are both associated with a higher rate of PPCs post lung cancer resection. COPD, independent of smoking status, is also associated with an increased overall post-operative complication rate and length of hospital stay. An emphasis on COPD treatment optimisation, rather than smoking cessation in isolation, may help improve postoperative outcomes. © 2022 Jeganathan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Authors: Jeganathan, Vishnu , Knight, Simon , Bricknell, Matthew , Ridgers, Anna , Wong, Raymond , Brazzale, Danny , Ruehland, Warren , Rahman, Muhammad Aziz , Leong, Tracy , McDonald, Christine
- Date: 2022
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 17, no. 3 March (2022), p.
- Full Text:
- Reviewed:
- Description: Introduction Smoking and chronic obstructive pulmonary disease (COPD) are associated with an increased risk of post-operative pulmonary complications (PPCs) following lung cancer resection. It remains unclear whether smoking cessation reduces this risk. Methods Retrospective review of a large, prospectively collected database of over 1000 consecutive resections for lung cancer in a quaternary lung cancer centre over a 23-year period. Results One thousand and thirteen patients underwent curative-intent lobectomy or pneumonectomy between 1995 and 2018. Three hundred and sixty-two patients (36%) were ex-smokers, 314 (31%) were current smokers and 111 (11%) were never smokers. A pre-operative diagnosis of COPD was present in 57% of current smokers, 57% of ex-smokers and 20% of never smokers. Just over 25% of patients experienced a PPC. PPCs were more frequent in current smokers compared to never smokers (27% vs 17%, p = 0.036), however, no difference was seen between current and ex-smokers (p = 0.412) or between never and ex-smokers (p = 0.113). Those with a diagnosis of COPD, independent of smoking status, had a higher frequency of both PPCs (65% vs 35%, p<0.01) and overall complications (60% vs 40%, p<0.01) as well as a longer length of hospital stay (10 vs 9 days, p<0.01). Conclusion Smoking and COPD are both associated with a higher rate of PPCs post lung cancer resection. COPD, independent of smoking status, is also associated with an increased overall post-operative complication rate and length of hospital stay. An emphasis on COPD treatment optimisation, rather than smoking cessation in isolation, may help improve postoperative outcomes. © 2022 Jeganathan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
COVID-19 : psychological distress, fear, and coping strategies among community members across the United Arab Emirates
- Al Dweik, Rania, Rahman, Muhammad Aziz, Ahamed, Fathima, Ramada, Heba, Al Sheble, Yousef, ElTaher, Sondos, Cross, Wendy, Elsori, Deena
- Authors: Al Dweik, Rania , Rahman, Muhammad Aziz , Ahamed, Fathima , Ramada, Heba , Al Sheble, Yousef , ElTaher, Sondos , Cross, Wendy , Elsori, Deena
- Date: 2023
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 18, no. 3 March (2023), p.
- Full Text:
- Reviewed:
- Description: Background The COVID-19 pandemic impacted the psychosocial well-being of the United Arab Emirates [UAE] population like other communities internationally. Objectives We aimed to identify the factors associated with psychological distress, fear, and coping amongst community members across the UAE. Methods We conducted a cross-sectional online survey across the UAE during November 2020. Adults aged
- Authors: Al Dweik, Rania , Rahman, Muhammad Aziz , Ahamed, Fathima , Ramada, Heba , Al Sheble, Yousef , ElTaher, Sondos , Cross, Wendy , Elsori, Deena
- Date: 2023
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 18, no. 3 March (2023), p.
- Full Text:
- Reviewed:
- Description: Background The COVID-19 pandemic impacted the psychosocial well-being of the United Arab Emirates [UAE] population like other communities internationally. Objectives We aimed to identify the factors associated with psychological distress, fear, and coping amongst community members across the UAE. Methods We conducted a cross-sectional online survey across the UAE during November 2020. Adults aged
MICFuzzy : a maximal information content based fuzzy approach for reconstructing genetic networks
- Gamage, Hasini, Chetty, Madhu, Lim, Suryani, Hallinan, Jennifer
- Authors: Gamage, Hasini , Chetty, Madhu , Lim, Suryani , Hallinan, Jennifer
- Date: 2023
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 18, no. 7 July (2023), p.
- Full Text:
- Reviewed:
- Description: In systems biology, the accurate reconstruction of Gene Regulatory Networks (GRNs) is crucial since these networks can facilitate the solving of complex biological problems. Amongst the plethora of methods available for GRN reconstruction, information theory and fuzzy concepts-based methods have abiding popularity. However, most of these methods are not only complex, incurring a high computational burden, but they may also produce a high number of false positives, leading to inaccurate inferred networks. In this paper, we propose a novel hybrid fuzzy GRN inference model called MICFuzzy which involves the aggregation of the effects of Maximal Information Coefficient (MIC). This model has an information theory-based pre-processing stage, the output of which is applied as an input to the novel fuzzy model. In this preprocessing stage, the MIC component filters relevant genes for each target gene to significantly reduce the computational burden of the fuzzy model when selecting the regulatory genes from these filtered gene lists. The novel fuzzy model uses the regulatory effect of the identified activator-repressor gene pairs to determine target gene expression levels. This approach facilitates accurate network inference by generating a high number of true regulatory interactions while significantly reducing false regulatory predictions. The performance of MICFuzzy was evaluated using DREAM3 and DREAM4 challenge data, and the SOS real gene expression dataset. MICFuzzy outperformed the other state-of-the-art methods in terms of F-score, Matthews Correlation Coefficient, Structural Accuracy, and SS_mean, and outperformed most of them in terms of efficiency. MICFuzzy also had improved efficiency compared with the classical fuzzy model since the design of MICFuzzy leads to a reduction in combinatorial computation. Copyright: © 2023 Nakulugamuwa Gamage et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Authors: Gamage, Hasini , Chetty, Madhu , Lim, Suryani , Hallinan, Jennifer
- Date: 2023
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 18, no. 7 July (2023), p.
- Full Text:
- Reviewed:
- Description: In systems biology, the accurate reconstruction of Gene Regulatory Networks (GRNs) is crucial since these networks can facilitate the solving of complex biological problems. Amongst the plethora of methods available for GRN reconstruction, information theory and fuzzy concepts-based methods have abiding popularity. However, most of these methods are not only complex, incurring a high computational burden, but they may also produce a high number of false positives, leading to inaccurate inferred networks. In this paper, we propose a novel hybrid fuzzy GRN inference model called MICFuzzy which involves the aggregation of the effects of Maximal Information Coefficient (MIC). This model has an information theory-based pre-processing stage, the output of which is applied as an input to the novel fuzzy model. In this preprocessing stage, the MIC component filters relevant genes for each target gene to significantly reduce the computational burden of the fuzzy model when selecting the regulatory genes from these filtered gene lists. The novel fuzzy model uses the regulatory effect of the identified activator-repressor gene pairs to determine target gene expression levels. This approach facilitates accurate network inference by generating a high number of true regulatory interactions while significantly reducing false regulatory predictions. The performance of MICFuzzy was evaluated using DREAM3 and DREAM4 challenge data, and the SOS real gene expression dataset. MICFuzzy outperformed the other state-of-the-art methods in terms of F-score, Matthews Correlation Coefficient, Structural Accuracy, and SS_mean, and outperformed most of them in terms of efficiency. MICFuzzy also had improved efficiency compared with the classical fuzzy model since the design of MICFuzzy leads to a reduction in combinatorial computation. Copyright: © 2023 Nakulugamuwa Gamage et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Leaders' creation of shared identity impacts group members' effort and performance : evidence from an exercise task
- Stevens, Mark, Rees, Tim, Steffens, Niklas, Haslam, S., Coffee, Pete, Polman, Remco
- Authors: Stevens, Mark , Rees, Tim , Steffens, Niklas , Haslam, S. , Coffee, Pete , Polman, Remco
- Date: 2019
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 14, no. 7 (2019), p.
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- Description: There is growing evidence that leaders' effectiveness derives in part from their creation of a sense of identity that is shared by members of a group they are attempting to lead (i.e., their identity entrepreneurship). Little is known, however, about the impact of identity entrepreneurship in sport and exercise settings, particularly in relation to its effect on group members' effort and performance. Using a pre-post between subjects experimental design, we examined the effect of leaders' identity entrepreneurship on group members' effort and performance during 5km cycling time trials. Following a baseline session (in which time trials were completed individually), participants (N = 72) were randomly allocated to either a high or low identity entrepreneurship condition, and further randomly divided into groups of five (including a leader who was a confederate). In the subsequent test sessions (which participants attended with their fellow group members), leaders displayed either high or low identity entrepreneurship behaviors. Results indicated that, compared to participants in the low identity entrepreneurship condition, those in the high identity entrepreneurship condition maintained greater effort (maximum heart rate), and demonstrated improved (rather than poorer) performance (average power output in the first 60 seconds of time trials). Examination of pacing showed that the largest increases in participants' average power output occurred in the early stages of their second time trials for those in the high identity entrepreneurship condition only. Results provide causal evidence that leaders who create a shared sense of identity among team members are able to inspire greater participant effort and performance. © 2019 Stevens et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Authors: Stevens, Mark , Rees, Tim , Steffens, Niklas , Haslam, S. , Coffee, Pete , Polman, Remco
- Date: 2019
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 14, no. 7 (2019), p.
- Full Text:
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- Description: There is growing evidence that leaders' effectiveness derives in part from their creation of a sense of identity that is shared by members of a group they are attempting to lead (i.e., their identity entrepreneurship). Little is known, however, about the impact of identity entrepreneurship in sport and exercise settings, particularly in relation to its effect on group members' effort and performance. Using a pre-post between subjects experimental design, we examined the effect of leaders' identity entrepreneurship on group members' effort and performance during 5km cycling time trials. Following a baseline session (in which time trials were completed individually), participants (N = 72) were randomly allocated to either a high or low identity entrepreneurship condition, and further randomly divided into groups of five (including a leader who was a confederate). In the subsequent test sessions (which participants attended with their fellow group members), leaders displayed either high or low identity entrepreneurship behaviors. Results indicated that, compared to participants in the low identity entrepreneurship condition, those in the high identity entrepreneurship condition maintained greater effort (maximum heart rate), and demonstrated improved (rather than poorer) performance (average power output in the first 60 seconds of time trials). Examination of pacing showed that the largest increases in participants' average power output occurred in the early stages of their second time trials for those in the high identity entrepreneurship condition only. Results provide causal evidence that leaders who create a shared sense of identity among team members are able to inspire greater participant effort and performance. © 2019 Stevens et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Confirmatory factor analysis and exploratory structural equation modeling of the factor structure of the Questionnaire of Cognitive and Affective Empathy (QCAE)
- Gomez, Rapson, Brown, Taylor, Watson, Shaun, Stavropoulos, Vasileios
- Authors: Gomez, Rapson , Brown, Taylor , Watson, Shaun , Stavropoulos, Vasileios
- Date: 2022
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 17, no. 2 February (2022), p.
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- Description: The Questionnaire of Cognitive and Affective Empathy (QCAE) is a multiple dimensional measure of cognitive empathy [comprising primary factors for perspective taking (PT), online simulation (OS)], and affective empathy [comprising primary factors for emotion contagion (EC), proximal responsivity (PRO), and peripheral responsivity (PER)]. This study used independent clusters confirmatory factor analysis (ICM-CFA) and exploratory structural equation modeling (ESEM) to examine the scale’s factor structure. A general community sample of 203 (men = 43, women = 160) between 17 and 63 years completed the QCAE. Although both the five-factor oblique and second order factor models showed good model fit, and clarity in the pattern of factor loadings, in the second-order factor model, none of the primary factors loaded significantly on their respective secondary factors, thereby favoring the five-factor oblique model. The factors in this model were supported in terms of external validity. Despite this, the factor for PRO in this model showed low reliability for meaning interpretation. A revised four-factor oblique model without the PRO factor showed good fit, clarity in the pattern of factor loadings, and reliability and validity for the factors in this model, thereby suggesting this to be the best model to represent ratings on the QCAE. Copyright: © 2022 Gomez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Authors: Gomez, Rapson , Brown, Taylor , Watson, Shaun , Stavropoulos, Vasileios
- Date: 2022
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 17, no. 2 February (2022), p.
- Full Text:
- Reviewed:
- Description: The Questionnaire of Cognitive and Affective Empathy (QCAE) is a multiple dimensional measure of cognitive empathy [comprising primary factors for perspective taking (PT), online simulation (OS)], and affective empathy [comprising primary factors for emotion contagion (EC), proximal responsivity (PRO), and peripheral responsivity (PER)]. This study used independent clusters confirmatory factor analysis (ICM-CFA) and exploratory structural equation modeling (ESEM) to examine the scale’s factor structure. A general community sample of 203 (men = 43, women = 160) between 17 and 63 years completed the QCAE. Although both the five-factor oblique and second order factor models showed good model fit, and clarity in the pattern of factor loadings, in the second-order factor model, none of the primary factors loaded significantly on their respective secondary factors, thereby favoring the five-factor oblique model. The factors in this model were supported in terms of external validity. Despite this, the factor for PRO in this model showed low reliability for meaning interpretation. A revised four-factor oblique model without the PRO factor showed good fit, clarity in the pattern of factor loadings, and reliability and validity for the factors in this model, thereby suggesting this to be the best model to represent ratings on the QCAE. Copyright: © 2022 Gomez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Understanding and optimising support resources to facilitate CALD student and supervisor allied health fieldwork experiences
- Newton, Fiona, Lee, Den-Ching, Brito, Sara
- Authors: Newton, Fiona , Lee, Den-Ching , Brito, Sara
- Date: 2023
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 18, no. 8 August (2023), p.
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- Description: Background Although fieldwork supervisors and culturally and linguistically diverse (CALD) students can experience challenges during allied health placements, there is little holistic understanding of how they view and use support resources to address these challenges. This study sought to identify, codify, and map the perceived value attached to support resources used or sought by CALD students and fieldwork supervisors and to ascertain areas where they could be optimised and better presented to users. Methods We conducted a thematic analysis to examine interview and open-ended survey responses from CALD students (n = 18) and fieldwork supervisors (n = 161) respectively. Findings The six generated themes depicted different patterns of perceived value in university and non-university support resources and spanned three levels of specificity: general, discipline-contextualised, and individualised. Fieldwork supervisors valued a staged approach to support resource design and use for CALD students commencing with general level resources to build foundational language skills and socio-cultural familiarisation and moving on to include disciple-contextualised supports, preplacement mechanisms to monitor student readiness, and formalised mechanisms to enable tailoring of placements. CALD students, however, often undervalued institutional general resources relative to discipline-contextualised resources. The commonality of support resources valued and sought by supervisors from different fields suggests they could be optimised for delivery via an inter-professional community of practice. Conclusion Identifying and mapping the perceived value attached to support resources provides actionable insights into how to enhance the ‘fit’ between resources and user needs. Drawing the often-fragmented support resources into a cohesive ecosystem focused around perceived value at different levels of specificity allows CALD students and educators to better conceptualise the types of benefits that can accrue from taking a broader and staged approach to fieldwork placement preparations. Knowing this ecosystem encapsulates what prior uses find of value may enhance perceptions of resource relevance in the minds of new users. © 2023 Newton et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Authors: Newton, Fiona , Lee, Den-Ching , Brito, Sara
- Date: 2023
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 18, no. 8 August (2023), p.
- Full Text:
- Reviewed:
- Description: Background Although fieldwork supervisors and culturally and linguistically diverse (CALD) students can experience challenges during allied health placements, there is little holistic understanding of how they view and use support resources to address these challenges. This study sought to identify, codify, and map the perceived value attached to support resources used or sought by CALD students and fieldwork supervisors and to ascertain areas where they could be optimised and better presented to users. Methods We conducted a thematic analysis to examine interview and open-ended survey responses from CALD students (n = 18) and fieldwork supervisors (n = 161) respectively. Findings The six generated themes depicted different patterns of perceived value in university and non-university support resources and spanned three levels of specificity: general, discipline-contextualised, and individualised. Fieldwork supervisors valued a staged approach to support resource design and use for CALD students commencing with general level resources to build foundational language skills and socio-cultural familiarisation and moving on to include disciple-contextualised supports, preplacement mechanisms to monitor student readiness, and formalised mechanisms to enable tailoring of placements. CALD students, however, often undervalued institutional general resources relative to discipline-contextualised resources. The commonality of support resources valued and sought by supervisors from different fields suggests they could be optimised for delivery via an inter-professional community of practice. Conclusion Identifying and mapping the perceived value attached to support resources provides actionable insights into how to enhance the ‘fit’ between resources and user needs. Drawing the often-fragmented support resources into a cohesive ecosystem focused around perceived value at different levels of specificity allows CALD students and educators to better conceptualise the types of benefits that can accrue from taking a broader and staged approach to fieldwork placement preparations. Knowing this ecosystem encapsulates what prior uses find of value may enhance perceptions of resource relevance in the minds of new users. © 2023 Newton et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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