- Title
- Is post-transplant metabolic syndrome associated with pre-liver transplant visceral adipose tissue area?
- Creator
- Woodward, Aidan; Wallen, Matthew; Ryan, John; Hall, Adrian; Ward, Leigh; Coombes, Jeff; Macdonald, Graeme
- Date
- 2020
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/193951
- Identifier
- vital:18290
- Identifier
-
https://doi.org/10.1016/j.clnesp.2020.07.018
- Identifier
- ISSN:2405-4577 (ISSN)
- Abstract
- Background: Post-liver transplant metabolic syndrome (PTMS) is a significant independent risk factor for the development of cardiovascular disease. The impact of pre-transplant body composition on the risk of developing PTMS has not been evaluated and was the aim of this study. Methods: Seventy-five consecutive adult patients listed for liver transplant were included in the analysis. Anthropometric and metabolic data were collected pre-transplant and at three months post-transplant. Metabolic syndrome was defined in accordance with international guidelines. Skeletal muscle area (SMA), visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) areas were derived from computed tomography. Results: Ten patients (13%) developed de novo PTMS by 3 months post-transplant. Patients who developed PTMS had higher pre-transplant body mass index (BMI) (P = 0.01), VAT (P = 0.001) and SAT (P = 0.008). Univariate logistic regression found that BMI, VAT and SAT were significant predictors for the development of PTMS. After stepwise multivariate analysis, only VAT remained a significant predictor (OR 1.02, 95%CI 1.01–1.04; P = 0.04). Conclusions: Higher pre-transplant VAT is independently associated with the development of metabolic syndrome three months post-transplant. Body composition analysis using cross-sectional imaging prior to liver transplant can assist with identifying patients at greatest risk for developing PTMS. © 2020 European Society for Clinical Nutrition and Metabolism
- Publisher
- Elsevier Ltd
- Relation
- Clinical Nutrition ESPEN Vol. 39, no. (2020), p. 61-66
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- Copyright © 2020 European Society for Clinical Nutrition and Metabolism
- Subject
- 3202 Clinical sciences; 3210 Nutrition and dietetics; Liver transplantation; Metabolic syndrome; Visceral adipose tissue
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