- Title
- Both low and high levels of low-density lipoprotein cholesterol are risk factors for diabetes diagnosis in Chinese adults
- Creator
- Yang, Guang; Qian, Tingting; Sun, Hui; Xu, Qun; Hou, Xujuan; Hu, Wenqi; Zhang, Guang; Fang, Yan; Song, David; Chai, Zhonglin; Magliano, Dianna; Golledge, Jonathan; Wang, Yutang
- Date
- 2022
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/196449
- Identifier
- vital:18705
- Identifier
-
https://doi.org/10.1016/j.deman.2022.100050
- Identifier
- ISSN:2666-9706
- Abstract
- •The LDL-C reference interval was 1.48–3.77 mmol/L in Chinese adults.•Hypocholesterolemia was associated with a 57% higher risk for diabetes.•Hypercholesterolemia was associated with a 29% higher risk for diabetes. This study aimed to investigate whether both high and low levels of low-density lipoprotein cholesterol (LDL-C), i.e., hypercholesterolemia and hypocholesterolemia, were associated with diabetes in Chinese adults. This cross-sectional study included 22,557 Chinese adults. The LDL-C reference interval was determined from a healthy sub-cohort. Associations between hypocholesterolemia or hypercholesterolemia with diabetes were analyzed using binary logistic regression. The LDL-C reference interval was 1.48–3.77 mmol/L (57.23–145.78 mg/dL). Therefore, hypocholesterolemia, normocholesterolemia, and hypercholesterolemia were defined as an LDL-C concentration of <1.48, 1.48–3.77, and >3.77 mmol/L, respectively. Prevalence of diabetes was higher in people with hypocholesterolemia or hypercholesterolemia than that in people with normocholesterolemia. Hypocholesterolemia was associated with an increased multivariable-adjusted risk for diabetes diagnosis (odds ratio, 1.57 95% confidence interval, 1.18–2.08), and so was hypercholesterolemia (odds ratio, 1.29 95% confidence interval, 1.10–1.51). The results remained significant after exclusion of those who took lipid-lowering drugs from the analysis. This study demonstrated that both low and high levels of LDL-C were associated with a higher risk of diabetes diagnosis. Patients with either high or low LDL-C may need to be closely monitored for the risk of diabetes .
- Publisher
- Elsevier Masson SAS
- Relation
- Diabetes epidemiology and management Vol. 6, no. (2022), p. 100050
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Subject
- Diabetes mellitus; Dyslipidemia; Low-density lipoprotein; Reference interval; Risk factor; 3202 Clinical sciences
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