Exercise and the gut microbiome : implications for supportive care in cancer
- Hart, Nicholas, Wallen, Matthew, Farley, Morgan, Haywood, Darren, Boytar, Alexander, Secombe, Kate, Joseph, Ria, Chan, Raymond, Kenkhuis, Marlou-Floor, Buffart, Laurien, Skinner, Tina, Wardill, Hannah
- Authors: Hart, Nicholas , Wallen, Matthew , Farley, Morgan , Haywood, Darren , Boytar, Alexander , Secombe, Kate , Joseph, Ria , Chan, Raymond , Kenkhuis, Marlou-Floor , Buffart, Laurien , Skinner, Tina , Wardill, Hannah
- Date: 2023
- Type: Text , Journal article , Review
- Relation: Supportive Care in Cancer Vol. 31, no. 12 (2023), p.
- Relation: http://purl.org/au-research/grants/nhmrc/1194051
- Full Text: false
- Reviewed:
- Description: Purpose: Growing recognition of the gut microbiome as an influential modulator of cancer treatment efficacy and toxicity has led to the emergence of clinical interventions targeting the microbiome to enhance cancer and health outcomes. The highly modifiable nature of microbiota to endogenous, exogenous, and environmental inputs enables interventions to promote resilience of the gut microbiome that have rapid effects on host health, or response to cancer treatment. While diet, probiotics, and faecal microbiota transplant are primary avenues of therapy focused on restoring or protecting gut function in people undergoing cancer treatment, the role of physical activity and exercise has scarcely been examined in this population. Methods: A narrative review was conducted to explore the nexus between cancer care and the gut microbiome in the context of physical activity and exercise as a widely available and clinically effective supportive care strategy used by cancer survivors. Results: Exercise can facilitate a more diverse gut microbiome and functional metabolome in humans; however, most physical activity and exercise studies have been conducted in healthy or athletic populations, primarily using aerobic exercise modalities. A scarcity of exercise and microbiome studies in cancer exists. Conclusions: Exercise remains an attractive avenue to promote microbiome health in cancer survivors. Future research should elucidate the various influences of exercise modalities, intensities, frequencies, durations, and volumes to explore dose-response relationships between exercise and the gut microbiome among cancer survivors, as well as multifaceted approaches (such as diet and probiotics), and examine the influences of exercise on the gut microbiome and associated symptom burden prior to, during, and following cancer treatment. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Diet and exercise advice and referrals for cancer survivors : an integrative review of medical and nursing perspectives
- Joseph, Ria, Hart, Nicolas, Bradford, Natalie, Agbejule, Oluwaseyifunmi, Koczwara, Bogda, Chan, Alexandre, Wallen, Matthew, Chan, Raymond
- Authors: Joseph, Ria , Hart, Nicolas , Bradford, Natalie , Agbejule, Oluwaseyifunmi , Koczwara, Bogda , Chan, Alexandre , Wallen, Matthew , Chan, Raymond
- Date: 2022
- Type: Text , Journal article , Review
- Relation: Supportive Care in Cancer Vol. 30, no. 10 (2022), p. 8429-8439
- Full Text:
- Reviewed:
- Description: Purpose: To examine the perspectives of medical and nursing health professionals concerning their roles and responsibilities in providing dietary and exercise advice to cancer survivors, and referrals to allied health professionals. Methods: An integrative review. PubMed, CINAHL, PsycINFO, Embase, Web of Science databases, and bibliographies of relevant studies were searched from December 2011 to June 2021. All studies were eligible for inclusion. The Mixed-Methods Appraisal Tool (MMAT) was used to critically appraise included studies. Data were extracted and synthesised regarding the perspectives of medical and nursing health professionals on their roles, responsibilities, barriers, and facilitators. Results: Twenty-one studies involving 3401 medical and nursing health professionals and 264 cancer survivors of diverse cancer types were included. Ten quantitative, nine qualitative, and two mixed-methods studies were eligible. All included studies met at least 80% of the quality criteria in the MMAT. Major findings include the following: (1) medical and nursing health professionals were unclear on their roles in providing dietary and exercise advice to cancer survivors but agreed they play a key role in referrals to dietitians and exercise professionals; (2) most cancer survivors valued the involvement of their general practitioner when receiving dietary and exercise advice. Conclusion: Although medical and nursing health professionals understand that referrals to allied health professionals form part of their role, there is a lack of clarity regarding their roles to provide dietary and exercise advice to cancer survivors. Future studies should address barriers and facilitators of dietary and exercise advice and referral by medical and nursing health professionals. © 2022, Crown.
- Authors: Joseph, Ria , Hart, Nicolas , Bradford, Natalie , Agbejule, Oluwaseyifunmi , Koczwara, Bogda , Chan, Alexandre , Wallen, Matthew , Chan, Raymond
- Date: 2022
- Type: Text , Journal article , Review
- Relation: Supportive Care in Cancer Vol. 30, no. 10 (2022), p. 8429-8439
- Full Text:
- Reviewed:
- Description: Purpose: To examine the perspectives of medical and nursing health professionals concerning their roles and responsibilities in providing dietary and exercise advice to cancer survivors, and referrals to allied health professionals. Methods: An integrative review. PubMed, CINAHL, PsycINFO, Embase, Web of Science databases, and bibliographies of relevant studies were searched from December 2011 to June 2021. All studies were eligible for inclusion. The Mixed-Methods Appraisal Tool (MMAT) was used to critically appraise included studies. Data were extracted and synthesised regarding the perspectives of medical and nursing health professionals on their roles, responsibilities, barriers, and facilitators. Results: Twenty-one studies involving 3401 medical and nursing health professionals and 264 cancer survivors of diverse cancer types were included. Ten quantitative, nine qualitative, and two mixed-methods studies were eligible. All included studies met at least 80% of the quality criteria in the MMAT. Major findings include the following: (1) medical and nursing health professionals were unclear on their roles in providing dietary and exercise advice to cancer survivors but agreed they play a key role in referrals to dietitians and exercise professionals; (2) most cancer survivors valued the involvement of their general practitioner when receiving dietary and exercise advice. Conclusion: Although medical and nursing health professionals understand that referrals to allied health professionals form part of their role, there is a lack of clarity regarding their roles to provide dietary and exercise advice to cancer survivors. Future studies should address barriers and facilitators of dietary and exercise advice and referral by medical and nursing health professionals. © 2022, Crown.
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