- Title
- Cytoskeletal plakins in epithelial ovarian cancer
- Creator
- Wesley, Tamsin
- Date
- 2023
- Type
- Text; Thesis; PhD
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/199457
- Identifier
- vital:19228
- Abstract
- The plakin family of cytoskeletal proteins play an important role in cancer progression yet are under-studied in cancer, especially ovarian cancer. These large cytoskeletal proteins have primary roles in the maintenance of cytoskeletal integrity. They are also associated with scaffolds of intermediate filaments and hemidesmosomal adhesion complexes mediating signalling pathways that regulate cellular growth, migration, invasion and differentiation, as well as a stress response. Abnormalities of plakins, and the closely related spectraplakins, result in serious pathologies of skin, striated muscle and nervous tissue. Their prevalence in epithelial cells suggests that plakins may play a role in epithelial ovarian cancer progression and recurrence. This thesis sought to explore the expression of plakin proteins, particularly plectin (PLEC), desmoplakin (DSP), periplakin (PPL) and envoplakin (EVPL) in ovarian cancer progression, comparing surgical stages, historical Silverberg histological grading and current World Health Organisation (WHO) pathological classification of ovarian tumour types. The study also investigated the potential role that the plakin family of proteins may play in regulating cancer cell growth, survival, migration, invasion and drug resistance. It highlights potential relationships between plakins and epithelial-mesenchymal transition (EMT) and relates how these interactions may affect ovarian cancer progression, chemoresistance and ultimately recurrence. This study hypothesises that the molecular changes in the expression of plakins in benign ovarian tumours compared to various grades and stages of ovarian carcinomas, as well as floating cellular aggregates (spheroids) in the peritoneal ascites microenvironment, may contribute to the progression of the disease. It also attempts to understand these crucial changes in plakin expression in response to chemotherapy treatment and relate these findings in the perspective of disease recurrence.; Doctor of Philosophy
- Publisher
- Federation University Australia
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- Copyright Tamsin Wesley
- Rights
- Restricted access by author for 12 months starting May 2024
- Subject
- Plakins; Ovarian cancer; Chemoresistance; Metastasis; Integrins; Keratins
- Thesis Supervisor
- Ahmed, Nuzhat
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