- Title
- An examination of physical exercise therapy on quality of life (QoL) and mortality in men diagnosed with Prostate Cancer (PCa)
- Creator
- Khan, Nazib
- Date
- 2023
- Type
- Text; Thesis; PhD
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/199133
- Identifier
- vital:19149
- Abstract
- Prostate cancer (PCa) is the second most frequent malignancy in men worldwide, accounting for 27% of new cancer cases in men and responsible for 3.8% of worldwide male cancer deaths (2018). This risk is projected to double before 204, so it is surprising that there are no well- established modifiable risk factors for PCa diagnosis orr progression. Considering this, the following thesis consists of three original research studies that examined; (1) the moderating effect of physical activity and muscular strength on prostate cancer mortality; (2) the magnitude of effect from pooled therapeutic exercise studies to impact quality of life and adverse events in PCa patients following surgery; (3) the head-to-head comparative efficacy of individual exercise therapies to impact quality of life and adverse events following surgery. The sum of works presented in this thesis lead to the conclusion that 1) when PCa is the only lifetime cancer diagnosis, life expectancy is similar to lifetime cancer free counterparts whereas diagnosis of PCa with any other lifetime cancer is associated with a 30.2% lower life expectancy during 10-year follow-up. Physical activity has negligible effect on life-expectancy whereas handgrip strength accounts for ~4% of the difference in life-expectancy between PCa with any other lifetime cancer compared with controls; 2) Pooled evidence from randomised controlled trials (n=999 participants) identifies that perioperative exercise therapy (aerobic, resistance, pelvic floor, mind-body exercise, or mixed exercise (combined aerobic and resistance) has a positive impact on patient quality of life and adverse events in PCa patients undergoing surgery which is predominant in perceptions of symptom related QoL (SMD: 0.56, 111 95% CI’s [0.22-0.89]) more so than health related quality of life (HRQoL) (SMD: 0.02, 95% 112 CI’s [-0.16-0.20]; 3) Comparison of head-to-head efficacy of different therapeutic exercise interventions [Aerobic, resistance, pelvic floor, mind-body exercise or mixed exercise (combined aerobic and resistance)] identified pelvic floor muscle exercise to be the most favorable exercise therapy to maintain QoL in PCa patients undergoing surgery, partly due to the current lack of evidence to support other exercise therapies. These findings provide new knowledge to support the effective treatment of PCa patients.; Doctor of Philosophy
- Publisher
- Federation University Australia
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- Copyright Nazib Khan
- Rights
- Open Access
- Subject
- Prostate cancer; Exercise therapy; Aerobic exercise; Quality of life; RCT; Cohort study; Systematic review; Meta-analysis; Network meta-analysis
- Full Text
- Thesis Supervisor
- Grace, Fergal
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| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE2 | Australian Digital Thesis | 8 MB | Adobe Acrobat PDF | View Details Download |