- Title
- Human strongyloidiasis : complexities and pathways forward
- Creator
- Buonfrate, Dora; Bradbury, Richard; Watts, Matthew; Bisoffi, Zeno
- Date
- 2023
- Type
- Text; Journal article; Review
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/197990
- Identifier
- vital:18967
- Identifier
-
https://doi.org/10.1128/cmr.00033-23
- Identifier
- ISSN:0893-8512 (ISSN)
- Abstract
- Strongyloidiasis is a World Health Organization neglected tropical disease usually caused by Strongyloides stercoralis, a parasitic worm with a complex life cycle. Globally, 300-600 million people are infected through contact with fecally contaminated soil. An autoinfective component of the life cycle can lead to chronic infection that may be asymptomatic or cause long-term symptoms, including malnourishment in children. Low larval output can limit the sensitivity of detection in stool, with serology being effectivebut less sensitive in immunocompromise. Host immunosuppression can trigger catastrophic, fatal hyperinfection/dissemination, where large numbers of larvae pierce the bowel wall and disseminate throughout the organs. Stable disease is effectivelytreated by single-dose ivermectin, with disease in immunocompromised patients treated with multiple doses. Strategies for management include raising awareness, clarifying zoonotic potential, the development and use of effectivediagnostic tests for epidemiological studies and individual diagnosis, and the implementation of treatment programs with research into therapeutic alternatives and medication safety. © 2023 American Society for Microbiology. All rights reserved.
- Publisher
- American Society for Microbiology
- Relation
- Clinical Microbiology Reviews Vol. 36, no. 4 (2023), p.
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- Copyright © 2023 American Society for Microbiology
- Rights
- Open Access
- Subject
- 3207 Medical microbiology; Neglected tropical diseases; Soil-transmitted helminth; Strongyloides; Strongyloidiasis
- Full Text
- Reviewed
- Funder
- This work received funds from the Italian Ministry of Health: “Ricerca Corrente”, Linea 2.
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