http://researchonline.federation.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 Genetic aetiology of self-harm ideation and behaviour http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14755 156,000). We also perform genome wide gene-based tests and characterize the SNP heritability and genetic correlations between these traits. Finally, we test whether polygenic risk scores (PRS) for self-harm ideation and self-harm behaviour predict suicide attempt, suicide thoughts and non-suicidal self-harm (NSSH) in an independent target sample of 8,703 Australian adults. Our GWAS results identified one genome-wide significant locus associated with each of the two phenotypes. SNP heritability (hsnp2) estimates were ~10%, and both traits were highly genetically correlated (LDSC rg > 0.8). Gene-based tests identified seven genes associated with self-harm ideation and four with self-harm behaviour. Furthermore, in the target sample, PRS for self-harm ideation were significantly associated with suicide thoughts and NSSH, and PRS for self-harm behaviour predicted suicide thoughts and suicide attempt. Follow up regressions identified a shared genetic aetiology between NSSH and suicide thoughts, and between suicide thoughts and suicide attempt. Evidence for shared genetic aetiology between NSSH and suicide attempt was not statistically significant. © 2020, The Author(s).]]> Wed 07 Apr 2021 14:02:50 AEST ]]> Cohort profile : the Australian genetics of depression study http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14577 Wed 07 Apr 2021 14:02:40 AEST ]]> Associations between polygenic risk for tobacco and alcohol use and liability to tobacco and alcohol use, and psychiatric disorders in an independent sample of 13,999 Australian adults http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14265 Wed 07 Apr 2021 14:02:21 AEST ]]> Big Five personality traits and alcohol, nicotine, cannabis, and gambling disorder comorbidity http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14144 Wed 07 Apr 2021 14:02:13 AEST ]]> Educational attainment polygenic scores : examining evidence for gene-environment interplay with adolescent alcohol, tobacco and cannabis use http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17990 Tue 27 Jun 2023 12:14:42 AEST ]]> Adolescent substance use and high school noncompletion : exploring the nature of the relationship using a discordant twin design http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17441 Thu 23 Mar 2023 11:13:03 AEDT ]]> Cyan Moon crew preparation for the Sydney To Hobart Yacht Race March 2023 http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:18587 Thu 16 Nov 2023 11:02:44 AEDT ]]> High-intensity drinking in adult Australian twins http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14477 Thu 03 Feb 2022 12:44:00 AEDT ]]> Does a disaster worsen anxiety when you are already anxious? Psychological consequences following exposure to a M7.1 earthquake in an outpatient anxiety disorder population http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17342 Thu 02 Mar 2023 16:35:57 AEDT ]]>