http://researchonline.federation.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 The composition and stability of the faecal microbiota of merino sheep http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14272 Wed 07 Apr 2021 14:02:21 AEST ]]> Proteomic identification of galectin-11 and 14 ligands from Haemonchus contortus http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13257 Wed 07 Apr 2021 14:01:25 AEST ]]> A novel ex vivo immunoproteomic approach characterising Fasciola hepatica tegumental antigens identified using immune antibody from resistant sheep http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11762 Wed 07 Apr 2021 13:57:02 AEST ]]> Modulation of Haemonchus contortus infection by depletion of γδ+ T cells in parasite resistant Canaria Hair Breed sheep http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11394 Wed 07 Apr 2021 13:56:42 AEST ]]> Liver fluke vaccines in ruminants : Strategies, progress and future opportunities http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11304 Wed 07 Apr 2021 13:56:39 AEST ]]> Cloning, expression, purification and crystallographic studies of galectin-11 from domestic sheep (Ovis aries) http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11293 Wed 07 Apr 2021 13:56:38 AEST ]]> Low cost whole-organism screening of compounds for anthelmintic activity http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11288 Wed 07 Apr 2021 13:56:38 AEST ]]> Prospects for immunoprophylaxis against fasciola hepatica (Liver Fluke) http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11301 Wed 07 Apr 2021 13:56:38 AEST ]]> Discovery of novel Schistosoma japonicum antigens using a targeted protein microarray approach http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11274 Wed 07 Apr 2021 13:56:37 AEST ]]> Dynamics of IL-4 and IL-13 expression in the airways of sheep following allergen challenge http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11270 2 cytokines. We hypothesized that airway exposure to HDM allergen would induce or elevate the expression profile of IL-4 and IL-13 during the allergic airway response in this large animal model of asthma. Methods: Bronchoalveolar lavage (BAL) samples were collected from saline-and house dust mite (HDM)-challenged lung lobes of sensitized sheep from 0 to 48h post-challenge. BAL cytokines (IL-4, IL-13, IL-6, IL-10, TNF-aα) were each measured by ELISA. IL-4 and IL-13 expression was assessed in BAL leukocytes by flow cytometry and in airway tissue sections by immunohistology. Results: IL-4 and IL-13 were increased in BAL samples following airway allergen challenge. HDM challenge resulted in a significant increase in BAL IL-4 levels at 4h compared to saline-challenged airways, while BAL IL-13 levels were elevated at all time-points after allergen challenge. IL-6 levels were maintained following HDM challenge but declined after saline challenge, while HDM administration resulted in an acute elevation in IL-10 at 4h but no change in TNF-aα levels over time. Lymphocytes were the main early source of IL-4, with IL-4 release by alveolar macrophages (AMs) prominent from 24h post-allergen challenge. IL-13 producing AMs were increased at 4 and 24h following HDM compared to saline challenge, and tissue staining provided evidence of IL-13 expression in airway epithelium as well as immune cells in airway tissue. Conclusion: In a sheep model of allergic asthma, airway inflammation is accompanied by the temporal release of key cytokines following allergen exposure that primarily reflects the Th2-driven nature of the immune response in asthma. The present study demonstrates for the first time the involvement of IL-4 and IL-13 in a relevant large animal model of allergic airways disease. © 2015 Liravi et al.]]> Wed 07 Apr 2021 13:56:37 AEST ]]> Evaluation of a dry powder delivery system for laninamivir in a ferret model of influenza infection http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11281 Wed 07 Apr 2021 13:56:37 AEST ]]> Galectin-11 : A novel host mediator targeting specific stages of the gastrointestinal nematode parasite, Haemonchus contortus http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11287 Wed 07 Apr 2021 13:56:37 AEST ]]> Immunity to Haemonchus contortus and Vaccine development http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11280 Wed 07 Apr 2021 13:56:37 AEST ]]> The in vitro anthelmintic effects of plumbagin on newly excysted and 4-weeks-old juvenile parasites of Fasciola gigantica http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11271 Wed 07 Apr 2021 13:56:37 AEST ]]> Generation of a Novel Bacteriophage Library displaying scFv antibody fragments from the natural Buffalo host to identify antigens from adult Schistosoma japonicum for diagnostic development http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11263 Wed 07 Apr 2021 13:56:36 AEST ]]> Potential role for mucosal IgA in modulating Haemonchus contortus adult worm infection in sheep http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11261 Wed 07 Apr 2021 13:56:36 AEST ]]> Specific humoral response of hosts with variable schistosomiasis susceptibility http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11240 Wed 07 Apr 2021 13:56:34 AEST ]]> Ovine Disease Resistance: Integrating comparative and functional genomics approaches in a genome information-poor Species http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11004 Wed 07 Apr 2021 13:56:19 AEST ]]> Comparison of Cytokine profile between Indonesian thin-tailed and merino sheep during A primary infection with fasciola gigantica http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10931 Wed 07 Apr 2021 13:56:18 AEST ]]> Using the local immune response from the natural buffalo host to generate an antibody fragment library that binds the early larval stages of Schistosoma japonicum http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10248 Wed 07 Apr 2021 13:55:35 AEST ]]> Current status for gastrointestinal nematode diagnosis in small ruminants: where are we and where are we going? http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10048 Wed 07 Apr 2021 13:55:21 AEST ]]> A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6621 Wed 07 Apr 2021 13:46:12 AEST ]]> Comparative experimental Haemonchus contortus infection of two sheep breeds native to the Canary Islands http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6591 Wed 07 Apr 2021 13:46:10 AEST ]]> Fecundity in adult Haemonchus contortus parasites is correlated with abomasal tissue eosinophils and gamma-delta T cells in resistant Canaria Hair Breed sheep http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6592 Wed 07 Apr 2021 13:46:10 AEST ]]> Immune mechanisms of resistance to gastrointestinal nematode infections in sheep http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6584 Wed 07 Apr 2021 13:46:10 AEST ]]> Evaluation of the immune responses induced by four targeted DNA vaccines encoding the juvenile liver fluke antigen, cathepsin B in a mouse model http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6569 Wed 07 Apr 2021 13:46:09 AEST ]]> Liver fluke vaccines : Vaccination against Fasciolosis by a multivalent vaccine of recombinant stage-specific antigens http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6570 Wed 07 Apr 2021 13:46:09 AEST ]]> The relationship between the rapid rejection of Haemonchus contortus larvae with cells and mediators in abomasal tissues in immune sheep http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6567 Wed 07 Apr 2021 13:46:09 AEST ]]> Vaccination against fasciolosis by a multivalent vaccine of stage-specific antigens http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6571 Wed 07 Apr 2021 13:46:09 AEST ]]> Dual oxidase 2 and glutathione peroxidase gene expression are elevated in hyperimmunized sheep challenged with Haemonchus contortus http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6564 Wed 07 Apr 2021 13:46:08 AEST ]]> Field vaccination of sheep with a larval-specific antigen of the gastrointestinal nematode, Haemonchus contortus, confers significant protection against an experimental challenge infection http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6550 Wed 07 Apr 2021 13:46:08 AEST ]]> Local immune responses of the Chinese water buffalo, Bubalus bubalis, against Schistosoma japonicum larvae: crucial insights for vaccine design http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6556 Wed 07 Apr 2021 13:46:08 AEST ]]> Molecular cloning and characterisation of ovine dual oxidase 2 http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6565 Wed 07 Apr 2021 13:46:08 AEST ]]> Novel immunomic technologies for schistosome vaccine development http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6557 Wed 07 Apr 2021 13:46:08 AEST ]]> Overcoming liver fluke as a constraint to ruminant production in South-East Asia http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6549 Wed 07 Apr 2021 13:46:08 AEST ]]> The developing schistosome worms elicit distinct immune responses in different tissue regions http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6558 Wed 07 Apr 2021 13:46:08 AEST ]]> The effect of different adjuvants on immune parameters and protection following vaccination of sheep with a larval-specific antigen of the gastrointestinal nematode, Haemonchus contortus http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6548 Wed 07 Apr 2021 13:46:08 AEST ]]> The effect of plant tissue and vaccine formulation on the oral immunogenicity of a model plant-made antigen in sheep http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6551 Wed 07 Apr 2021 13:46:08 AEST ]]> Host responses during experimental infection with Fasciola gigantica and Fasciola hepatica in Merino sheep II. Development of a predictive index for Fasciola gigantica worm burden http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6541 Wed 07 Apr 2021 13:46:07 AEST ]]> Immune cell kinetics in the ovine abomasal mucosa following hyperimmunization and challenge with Haemonchus contortus http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6539 Wed 07 Apr 2021 13:46:07 AEST ]]> Improving animal and human health through understanding liver fluke immunology http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6546 Wed 07 Apr 2021 13:46:07 AEST ]]> Increased production through parasite control : can ancient breeds of sheep teach us new lessons? http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6547 Wed 07 Apr 2021 13:46:07 AEST ]]> Innate and adaptive resistance of Indonesian Thin Tail sheep to liver fluke: A comparative analysis of Fasciola gigantica and Fasciola hepatica infection http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6545 Wed 07 Apr 2021 13:46:07 AEST ]]> Overcoming liver fluke as a constraint to ruminant production in South-East Asia http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6542 Wed 07 Apr 2021 13:46:07 AEST ]]> Resistance to liver fluke infection in the natural sheep host is correlated with a type-1 cytokine response http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6544 Wed 07 Apr 2021 13:46:07 AEST ]]> The kinetics of local cytokine and galectin expression after challenge infection with the gastrointestinal nematode, Haemonchus contortus http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6538 Wed 07 Apr 2021 13:46:07 AEST ]]> Galectin secretion and binding to adult Fasciola hepatica during chronic liver fluke infection of sheep http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6504 Wed 07 Apr 2021 13:46:05 AEST ]]> Increased susceptibility to Haemonchus contortus infection by interleukin-5 modulation of eosinophil responses in sheep http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15223 Tue 30 Nov 2021 15:36:19 AEDT ]]> Investigation of the combined efficacy of two Haemonchus contortus vaccines in weaner Merino sheep http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:16920 Tue 29 Nov 2022 16:48:17 AEDT ]]> Teladorsagia circumcincta http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:18959 Tue 20 Feb 2024 13:44:10 AEDT ]]> The heritability of Nematodirus battus fecal egg counts http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17056 Tue 20 Dec 2022 14:46:26 AEDT ]]> The immune response to nematode infection http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:18183 Tue 15 Aug 2023 14:04:57 AEST ]]> Development and application of a faecal antigen diagnostic sandwich ELISA for estimating prevalence of Fasciola gigantica in cattle in central Java, Indonesia http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6602 15 flukes. A survey of 305 cattle in central Java over a 10-mo period validated this test in the field, demonstrating a high prevalence of fascioliasis and establishing the test as a useful diagnostic method to determine patent F. gigantica infections in cattle.]]> Tue 03 Aug 2021 16:55:14 AEST ]]> Quantifying the sources of variation in eosinophilia among Scottish blackface lambs with mixed, predominantly Teladorsagia circumcincta nematode infection http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15781 Thu 17 Mar 2022 12:02:08 AEDT ]]> Comparative evaluation of different molecular methods for DNA extraction from individual Teladorsagia circumcincta nematodes http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15332 Mon 25 Oct 2021 11:41:11 AEDT ]]> Vaccines for fasciola : new thinking for an old problem http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17016 Mon 19 Dec 2022 15:19:59 AEDT ]]> Effective pulmonary delivery of an aerosolized plasmid DNA vaccine via surface acoustic wave nebulization http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11289 Mon 10 May 2021 10:11:54 AEST ]]> The oligomeric assembly of galectin-11 is critical for anti-parasitic activity in sheep (Ovis aries) http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15237 Mon 06 Sep 2021 10:27:11 AEST ]]> Evaluation of the role of galectins in parasite immunity http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17815 Fri 19 May 2023 17:02:36 AEST ]]> The current status of anthelmintic resistance in a temperate region of Australia; implications for small ruminant farm management http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15235 Fri 03 Sep 2021 15:05:06 AEST ]]> Selection of multi-drug resistant influenza A and B viruses under zanamivir pressure and their replication fitness in ferrets http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15233 Fri 03 Sep 2021 15:05:05 AEST ]]>