http://researchonline.federation.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13720 2-fold difference, FDR (false discovery rate) <0.5] within AAA biopsies, of which miR-155 was the most differentially expressed (11.32-fold, FDR=0.414). This finding was confirmed by qPCR with the median relative expression of miR-155 being 3.26 and 0.63 within AAA body and AAA neck biopsies respectively (P=0.031). Circulating miR-155 was also increased in AAA patients compared with controls, with a 2.67-fold up-regulation at borderline significance (FDR=0.554). Two immunologically important miR-155 target genes, CTLA4 (cytotoxic T-lymphocyte-associated protein) and SMAD2, were assessed and found to be significantly down-regulated within AAA bodies compared with AAA necks (P=0.032 and P=0.026) as determined by qPCR and Western blotting respectively. Histology demonstrated dense accumulation of T-lymphocytes within the adventitial and outer medial layers of AAA body, but not neck tissue. The results of the present study suggest that miR-155 is overexpressed in AAA with potential implications in the pathogenesis of the condition.]]> Wed 07 Apr 2021 14:01:49 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13242 Wed 07 Apr 2021 14:01:24 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:12224 Wed 07 Apr 2021 14:00:31 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11278 Wed 07 Apr 2021 13:56:37 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:12377 Tue 19 Mar 2024 11:38:09 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15657 Mon 24 Jan 2022 14:15:13 AEDT ]]>