http://researchonline.federation.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14575 Wed 07 Apr 2021 14:02:39 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14448 Wed 07 Apr 2021 14:02:32 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11958 Wed 07 Apr 2021 13:57:15 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17730 Mon 15 May 2023 11:18:12 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15171 Mon 13 Sep 2021 17:28:12 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:18186 Mon 11 Sep 2023 10:11:40 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:16322 2 weeks) stimulation via TCR signalling, a condition likely to be found in both CRC tissue and pre-cancerous lesions, as these lesions are associated with mucosal barrier defects that allow microbes within the gut lumen to transit the barrier. These investigations found a novel, mixed Th1/Th2 cytokine response that included prodigious IL-13 expression. We found that the IL-13 produced by chronically stimulated MAIT cells was sufficient to signal to CRC cells and induce CRC cell transcriptional changes via the STAT6 pathway. Collectively, the findings of our study have provided new insights about the significance of MAIT cells in CRC and highlighted them as a potential target for immunotherapies to improve anti-tumour immunity in mucosal tissues.]]> Mon 01 Aug 2022 12:10:58 AEST ]]>