http://researchonline.federation.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 Synthesis and structure-activity relationship study of pyrrolidine-oxadiazoles as anthelmintics against Haemonchus contortus http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14457 Wed 07 Apr 2021 14:02:33 AEST ]]> A perspective on the discovery of selected compounds with anthelmintic activity against the barber's pole worm—Where to from here? http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14426 Wed 07 Apr 2021 14:02:31 AEST ]]> Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14034 Wed 07 Apr 2021 14:02:07 AEST ]]> Novel 1-Methyl-1H-pyrazole-5-carboxamide derivatives with potent anthelmintic activity http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13982 Wed 07 Apr 2021 14:02:04 AEST ]]> Structure-activity relationship studies of tolfenpyrad reveal subnanomolar inhibitors of haemonchus contortus development http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13983 Wed 07 Apr 2021 14:02:04 AEST ]]> Optimization of novel 1-Methyl-1H-Pyrazole-5-carboxamides leads to high potency larval development inhibitors of the Barber's pole worm http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13694 Wed 07 Apr 2021 14:01:48 AEST ]]> Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13022 Wed 07 Apr 2021 14:01:13 AEST ]]> Screening of the ‘Open Scaffolds’ collection from Compounds Australia identifies a new chemical entity with anthelmintic activities against different developmental stages of the barber's pole worm and other parasitic nematodes http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11934 90%) these stages. Furthermore, this compound completely inhibited the motility of female and male adults of Brugia malayi (50–100 μM) as well as microfilariae of both B. malayi and Dirofilaria immitis (heartworm). Overall, these results show that SN00797439 acts against genetically (evolutionarily) distant parasitic nematodes i.e. H. contortus and A. ceylanicum [strongyloids] vs. B. malayi and D. immitis [filarioids] vs. T. muris [enoplid], and, thus, might offer a novel, lead-like scaffold for the development of a relatively broad-spectrum anthelmintic. Our future work will focus on assessing the activity of SN00797439 against other pathogens that cause neglected tropical diseases, optimising analogs with improved biological activities and characterising their targets. © 2017 The Authors]]> Wed 07 Apr 2021 13:57:13 AEST ]]> Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11768 Wed 07 Apr 2021 13:57:02 AEST ]]> Low cost whole-organism screening of compounds for anthelmintic activity http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11288 Wed 07 Apr 2021 13:56:38 AEST ]]>