http://researchonline.federation.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 Neural suppression of miRNA-181a in the kidney elevates renin expression and exacerbates hypertension in Schlager mice http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14837 Wed 25 Nov 2020 10:04:34 AEDT ]]> A guide to the short, long and circular RNAs in hypertension and cardiovascular disease http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14597 Wed 07 Apr 2021 14:02:41 AEST ]]> May measurement month 2018 : A pragmatic global screening campaign to raise awareness of blood pressure by the international society of hypertension http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14048 Wed 07 Apr 2021 14:02:08 AEST ]]> Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13808 Wed 07 Apr 2021 14:01:55 AEST ]]> Renal nerves contribute to hypertension in Schlager BPH/2J mice http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13780 0.1). The depressor response to pentolinium was greater in BPH/2J than BPN/3J, but in both cases the response in RD mice was similar to sham. Enalaprilat decreased MAP more in RD BPH/2J compared to sham (−12 vs −3 mmHg, P < 0.001) but had no effect in BPN/3J. RD reduced renal noradrenaline in both strains but more so in BPH/2J. RD reduced renin mRNA and protein, but not plasma renin in BPH/2J to levels comparable with BPN/3J mice. We conclude that renal nerves contribute to hypertension in BPH mice as RD induced a sustained fall in MAP, which was associated with a reduction of intrarenal renin expression. The lack of inhibition of the depressor effects of pentolinium and enalaprilat by RD suggests that vasoconstrictor effects of the SNS or RAS are not involved.]]> Wed 07 Apr 2021 14:01:53 AEST ]]> Leukocyte telomere length variation due to DNA extraction method http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13727 Wed 07 Apr 2021 14:01:50 AEST ]]> MicroRNA-34a and tert act as epi-drivers of cardiac telomere length and polygenic cardiac hypertrophy http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13721 Wed 07 Apr 2021 14:01:49 AEST ]]> Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13698 Wed 07 Apr 2021 14:01:48 AEST ]]> Cardiomyocyte functional etiology in heart failure with preserved ejection fraction is distinctive - A new preclinical model http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13680 Wed 07 Apr 2021 14:01:47 AEST ]]> Involvement of human monogenic cardiomyopathy genes in experimental polygenic cardiac hypertrophy http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13538 Wed 07 Apr 2021 14:01:40 AEST ]]> Body mass index is negatively associated with telomere length : A collaborative cross-sectional meta-analysis of 87 observational studies http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13493 75 y), sex, and ethnicity. Results: Each unit increase in BMI corresponded to a-3.99 bp (95% CI: -5.17, -2.81 bp) difference in TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a -7.67 bp (95% CI:-10.03,-5.31 bp) difference. Each unit increase in BMI corresponded to a -1.58 × 10-3 unit T/S ratio (0.16% decrease; 95% CI: -2.14 × 10-3, -1.01 × 10-3) difference in ageand sex-adjusted relative TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a -2.58 × 10-3 unit T/S ratio (0.26% decrease; 95% CI: -3.92 × 10-3, -1.25 × 10-3). The associations were predominantly for the white pooled population. No sex differences were observed. Conclusions: A higher BMI is associated with shorter telomeres, especially in younger individuals. The presently observed difference is not negligible. Meta-analyses of longitudinal studies evaluating change in body weight alongside change in TL arewarranted.]]> Wed 07 Apr 2021 14:01:37 AEST ]]> A novel Y-specific long non-coding RNA associated with cellular lipid accumulation in HepG2 cells and Atherosclerosis-related genes http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13241 Wed 07 Apr 2021 14:01:24 AEST ]]> Telomeres, aging and exercise : Guilty by association? http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:12993 Wed 07 Apr 2021 14:01:11 AEST ]]> Dysregulation of c-kit expression parallels the development of spontaneous genetic cardiac hypertrophy http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:12775 Wed 07 Apr 2021 14:00:59 AEST ]]> A meta-analysis of gene expression signatures of blood pressure and hypertension http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:12206 Wed 07 Apr 2021 14:00:30 AEST ]]> Experimental and human evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin NGAL ) in the development of cardiac hypertrophy and heart failure http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11958 Wed 07 Apr 2021 13:57:15 AEST ]]> MicroRNAs in a hypertrophic heart : From foetal life to adulthood http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11963 Wed 07 Apr 2021 13:57:15 AEST ]]> Cardiac telomere length in heart development, function, and disease http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11761 Wed 07 Apr 2021 13:57:02 AEST ]]> Telomeres, exercise and cardiovascular disease : Finding the means to justify the ends http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11677 Wed 07 Apr 2021 13:56:58 AEST ]]> Epigenetic changes in leukocytes after 8 weeks of resistance exercise training http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11679 Wed 07 Apr 2021 13:56:58 AEST ]]> Genetics of blood pressure : Time to curate the collection http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11640 Wed 07 Apr 2021 13:56:56 AEST ]]> Genetic variation within the Y chromosome is not associated with histological characteristics of the atherosclerotic carotid artery or aneurysmal wall http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11392 Wed 07 Apr 2021 13:56:42 AEST ]]> Telomere length maintenance and cardio-metabolic disease prevention through exercise training http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11116 Wed 07 Apr 2021 13:56:26 AEST ]]> Contribution of microRNA to pathological fibrosis in cardiorenal syndrome : Impact of uremic toxins http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11075 Wed 07 Apr 2021 13:56:24 AEST ]]> Signatures of miR-181a on the renal transcriptome and blood pressure http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10772 Wed 07 Apr 2021 13:56:08 AEST ]]> Aortic augmentation index in endurance athletes : A role for cardiorespiratory fitness http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10766 Wed 07 Apr 2021 13:56:07 AEST ]]> Tripartite motif-containing 55 identified as functional candidate for spontaneous cardiac hypertrophy in the rat locus cardiac mass 22 http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10751 Wed 07 Apr 2021 13:56:06 AEST ]]> Coronary artery disease : Why we should consider the Y chromosome http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10738 Wed 07 Apr 2021 13:56:05 AEST ]]> Epigenetic modifications in essential hypertension http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10609 Wed 07 Apr 2021 13:55:57 AEST ]]> Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10546 Wed 07 Apr 2021 13:55:53 AEST ]]> Renal Mechanisms of Association between Fibroblast Growth Factor 1 and Blood Pressure http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10534 Wed 07 Apr 2021 13:55:52 AEST ]]> Genome-wide sperm DNA methylation changes after 3 months of exercise training in humans http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10525 Wed 07 Apr 2021 13:55:51 AEST ]]> Increased expression of telomere-regulating genes in endurance athletes with long leukocyte telomeres http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10529 0.05). Resting heart rate emerged as an independent predictor of leukocyte telomere length and TERT and TPP1 mRNA expression in stepwise regression models. To gauge whether volume of exercise was associated with leukocyte telomere length, we divided subjects into running and cycling tertiles (distance covered per week) and found individuals in the middle and highest tertiles had longer telomeres than individuals in the lowest tertile. These data emphasize the importance of cardiorespiratory fitness and exercise training in the prevention of biological aging. They also support the concept that moderate amounts of exercise training protects against biological aging, while higher amounts may not elicit additional benefits.]]> Wed 07 Apr 2021 13:55:51 AEST ]]> Circulating microRNAs and hypertension - From new insights into blood pressure regulation to biomarkers of cardiovascular risk http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10465 Wed 07 Apr 2021 13:55:50 AEST ]]> Telomere dynamics during aging in polygenic left ventricular hypertrophy http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10451 Wed 07 Apr 2021 13:55:49 AEST ]]> MicroRNAs in essential hypertension and blood pressure regulation http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10351 Wed 07 Apr 2021 13:55:42 AEST ]]> MicroRNAs mediate the cardioprotective effect of angiotensin-converting enzyme inhibition in acute kidney injury http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10353 Wed 07 Apr 2021 13:55:42 AEST ]]> A multi-omics glimpse into the biology of arterial stiffness http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10341 Wed 07 Apr 2021 13:55:41 AEST ]]> Runs of Homozygosity : Association with Coronary Artery Disease and Gene Expression in Monocytes and Macrophages http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10162 Wed 07 Apr 2021 13:55:29 AEST ]]> The emerging role of non-coding RNA in essential hypertension and blood pressure regulation http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10127 Wed 07 Apr 2021 13:55:26 AEST ]]> Measurement of absolute copy number variation reveals association with essential hypertension http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:9618 Wed 07 Apr 2021 13:54:52 AEST ]]> Coronary artery disease predisposing haplogroup I of the Y chromosome, aggression and sex steroids - Genetic association analysis http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:9603 1000 young apparently healthy white men from the general population. Each Y chromosome was classified into one of 13 most common European lineages. Androgens (DHEA-S, androstenedione, total testosterone) and their metabolites (total estradiol, estrone) were measured by radioimmunoassays. Information on five dimensions of aggression (total, physical, verbal, anger and hostility) was collected using Buss and Perry questionnaire. Results: Approximately 17% men inherited haplogroup I from their fathers. Carriers of haplogroup I showed lower scores of verbal aggression than men with other haplogroups (beta = -0.72, SE = 0.29, P = 0.012) and when further compared to carriers of most common R1a lineage and other haplogroups (beta = -1.03, SE = 0.34, P = 0.003). However, these associations did not survive a correction for multiple testing. Sex steroids did not show even nominal level of association with haplogroup I. Conclusion: Our data show no overall association between haplogroup I and sex-related phenotypes in young white men. These results also suggest that the previously identified association between haplogroup I and coronary artery disease is not likely mediated by unfavourable profile of sex steroids or heightened aggression early in life. (C) 2014 Elsevier Ireland Ltd. All rights reserved.]]> Wed 07 Apr 2021 13:54:51 AEST ]]> Report of the 3rd annual International Society of Hypertension New Investigator Symposium. http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:7659 Wed 07 Apr 2021 13:47:08 AEST ]]> Changes in the leukocyte methylome and its effect on cardiovascular-related genes after exercise http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:7624 Wed 07 Apr 2021 13:47:06 AEST ]]> 121 Telomere attrition is attenuated in ultra-marathon runners http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:7167 Wed 07 Apr 2021 13:46:40 AEST ]]> A novel interaction between sympathetic overactivity and aberrant regulation of renin by miR-181a in BPH/2J genetically hypertensive mice http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6926 Wed 07 Apr 2021 13:46:28 AEST ]]> Consumption of a low glycaemic index diet in late life extends lifespan of Nalb/c mice with differential effects on DNA damage http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6933 Wed 07 Apr 2021 13:46:28 AEST ]]> Small molecules, big effects: The role of microRNAs in regulation of cardiomyocyte death http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6459 Wed 07 Apr 2021 13:46:03 AEST ]]> Acute exercise leads to regulation of Telomere-Associated genes and MicroRNA expression in immune Cells http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5804 Wed 07 Apr 2021 13:45:22 AEST ]]> Exercise : Putting action into our epigenome http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5741 Wed 07 Apr 2021 13:45:18 AEST ]]> Urotensin-II system in genetic control of blood pressure and renal function http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5740 Wed 07 Apr 2021 13:45:18 AEST ]]> Leading the change: Second International Society of Hypertension New Investigators' Symposium http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5401 Wed 07 Apr 2021 13:45:02 AEST ]]> Early treatment to prevent hypertension: A laudable goal http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5368 Wed 07 Apr 2021 13:45:00 AEST ]]> Genetic mechanisms of vascular and renal damage http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5261 Wed 07 Apr 2021 13:44:54 AEST ]]> Longer leukocyte telomeres are associated with ultra-endurance exercise independent of cardiovascular risk factors http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5126 Wed 07 Apr 2021 13:44:45 AEST ]]> Male-specific region of the y chromosome and cardiovascular risk phylogenetic analysis and gene expression studies http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5099 Wed 07 Apr 2021 13:44:43 AEST ]]> Salt Loading in Canola Oil Fed SHRSP Rats Induces Endothelial Dysfunction http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5088 Wed 07 Apr 2021 13:44:42 AEST ]]> RNA sequencing data from the human kidney http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:4943 Wed 07 Apr 2021 13:44:32 AEST ]]> Reduced renal function may explain the higher prevalence of hyperuricemia in older people http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14995 Wed 07 Apr 2021 13:24:57 AEST ]]> Telomere therapy for chronic kidney disease http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17327 Wed 01 Mar 2023 15:16:28 AEDT ]]> Exercise, epigenetics, and aging http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:16466 Tue 30 Aug 2022 10:30:25 AEST ]]> Contributions of obesity to kidney health and disease: insights from Mendelian randomization and the human kidney transcriptomics http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17325 Tue 28 Feb 2023 14:32:09 AEDT ]]> Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:19129 Tue 26 Mar 2024 15:15:11 AEDT ]]> Deficiency of MicroRNA-181a results in transcriptome-wide cell-specific changes in the kidney and increases blood pressure http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17011 Tue 20 Dec 2022 15:35:27 AEDT ]]> May measurement month 2019 the global blood pressure screening campaign of the International Society of Hypertension http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14703 = 18 years) recruited through opportunistic sampling were screened at sites in 92 countries during May 2019. Ideally, 3 blood pressure readings were measured for each participant, and data on lifestyle factors and comorbidities were collected. Hypertension was defined as a systolic blood pressure >= 140 mm Hg, or a diastolic blood pressure >= 90 mm Hg (mean of the second and third readings) or taking antihypertensive medication. When necessary, multiple imputation was used to estimate participants' mean blood pressure. Mixed-effects models were used to evaluate associations between blood pressure and participant characteristics. Of 1 508 130 screenees 482 273 (32.0%) had never had a blood pressure measurement before and 513 337 (34.0%) had hypertension, of whom 58.7% were aware, and 54.7% were on antihypertensive medication. Of those on medication, 57.8% were controlled to <140/90 mm Hg, and 28.9% to <130/80 mm Hg. Of all those with hypertension, 31.7% were controlled to <140/90 mm Hg, and 350 825 (23.3%) participants had untreated or inadequately treated hypertension. Of those taking antihypertensive medication, half were taking only a single drug, and 25% reported using aspirin inappropriately. This survey is the largest ever synchronized and standardized contemporary compilation of global blood pressure data. This campaign is needed as a temporary substitute for systematic blood pressure screening in many countries worldwide.]]> Tue 19 Oct 2021 16:23:32 AEDT ]]> May measurement month 2017 : an analysis of blood pressure screening results worldwide http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13276 Tue 19 Oct 2021 11:50:57 AEDT ]]> Hyperuricemia is independently associated with hypertension in men under 60 years in a general Chinese population http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15666 Tue 18 Jan 2022 14:45:24 AEDT ]]> Transforming global approaches to chronic disease prevention and management across the lifespan : integrating genomics, behavior change, and digital health solutions http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:18803 Tue 16 Jan 2024 15:08:09 AEDT ]]> Renin-angiotensin system inhibitors in patients With COVID-19 : a meta-analysis of randomized controlled trials led by the International Society of Hypertension http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17626 Tue 09 May 2023 12:01:48 AEST ]]> Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14938 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency ≤ 0.01) variant BP associations (P < 5 × 10−8), of which 32 were in new BP-associated loci and 55 were independent BP-associated single-nucleotide variants within known BP-associated regions. Average effects of rare variants (44% coding) were ~8 times larger than common variant effects and indicate potential candidate causal genes at new and known loci (for example, GATA5 and PLCB3). BP-associated variants (including rare and common) were enriched in regions of active chromatin in fetal tissues, potentially linking fetal development with BP regulation in later life. Multivariable Mendelian randomization suggested possible inverse effects of elevated systolic and diastolic BP on large artery stroke. Our study demonstrates the utility of rare-variant analyses for identifying candidate genes and the results highlight potential therapeutic targets. © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. There are 286 authors of this articles not all are listed in this record.]]> Thu 25 Nov 2021 11:48:02 AEDT ]]> Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15857 Thu 24 Mar 2022 10:38:04 AEDT ]]> Secondary stroke prevention in polish adults: Results from the lipidogram2015 study http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15735 Thu 24 Feb 2022 09:28:04 AEDT ]]> Kidney omics in hypertension: from statistical associations to biological mechanisms and clinical applications http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17466 1000 common and rare genetic variants associated with BP and/or hypertension. The kidney is not only an organ of key relevance to BP regulation and the development of hypertension, but it also acts as the tissue mediator of genetic predisposition to hypertension. The identity of kidney genes, pathways, and related mechanisms underlying the genetic associations with BP has started to emerge through integration of genomics with kidney transcriptomics, epigenomics, and other omics as well as through applications of causal inference, such as Mendelian randomization. Single-cell methods further enabled mapping of BP-associated kidney genes to cell types, and in conjunction with other omics, started to illuminate the biological mechanisms underpinning associations of BP-associated genetic variants and kidney genes. Polygenic risk scores derived from genome-wide association studies and refined on kidney omics hold the promise of enhanced diagnostic prediction, whereas kidney omics-informed drug discovery is likely to contribute new therapeutic opportunities for hypertension and hypertension-mediated kidney damage. © 2022 International Society of Nephrology]]> Thu 23 Mar 2023 11:55:08 AEDT ]]> DNA copy number variations – Do these big mutations have a big effect on cardiovascular risk? http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14247 Thu 20 May 2021 10:20:30 AEST ]]> Human Y Chromosome Exerts Pleiotropic Effects on Susceptibility to Atherosclerosis http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14223 Thu 19 May 2022 12:38:25 AEST ]]> Highlights from the International Society of Hypertension's New Investigators Network during 2019 http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14433 Thu 19 May 2022 12:14:45 AEST ]]> 2020 International Society of Hypertension global hypertension practice guidelines http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14617 Thu 19 May 2022 12:02:09 AEST ]]> Molecular insights into genome-wide association studies of chronic kidney disease-defining traits http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13555 100 loci of chronic kidney disease-defining traits (CKD-dt). Molecular mechanisms underlying these associations remain elusive. Using 280 kidney transcriptomes and 9958 gene expression profiles from 44 non-renal tissues we uncover gene expression partners (eGenes) for 88.9% of CKD-dt GWAS loci. Through epigenomic chromatin segmentation analysis and variant effect prediction we annotate functional consequences to 74% of these loci. Our colocalisation analysis and Mendelian randomisation in >130,000 subjects demonstrate causal effects of three eGenes (NAT8B, CASP9 and MUC1) on estimated glomerular filtration rate. We identify a common alternative splice variant in MUC1 (a gene responsible for rare Mendelian form of kidney disease) and observe increased renal expression of a specific MUC1 mRNA isoform as a plausible molecular mechanism of the GWAS association signal. These data highlight the variants and genes underpinning the associations uncovered in GWAS of CKD-dt.]]> Thu 19 May 2022 11:08:51 AEST ]]> Lifestyle management of hypertension : International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:18750 140 mmHg and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of Hypertension guidelines), affects over 1.5 billion people worldwide. Hypertension is associated with increased risk of cardiovascular disease (CVD) events (e.g. coronary heart disease, heart failure and stroke) and death. An international panel of experts convened by the International Society of Hypertension College of Experts compiled lifestyle management recommendations as first-line strategy to prevent and control hypertension in adulthood. We also recommend that lifestyle changes be continued even when blood pressure-lowering medications are prescribed. Specific recommendations based on literature evidence are summarized with advice to start these measures early in life, including maintaining a healthy body weight, increased levels of different types of physical activity, healthy eating and drinking, avoidance and cessation of smoking and alcohol use, management of stress and sleep levels. We also discuss the relevance of specific approaches including consumption of sodium, potassium, sugar, fibre, coffee, tea, intermittent fasting as well as integrated strategies to implement these recommendations using, for example, behaviour change-related technologies and digital tools. **Please note that there are multiple authors for this article therefore only the name of the first 30 including Federation University Australia affiliates “Fadi Charchar, Priscilla Prestes, Britt Klein, Colette Browning, Olutope Akinnibosun and Shane Thomas” are provided in this record**]]> Thu 18 Jan 2024 11:16:43 AEDT ]]> The association between selected molecular biomarkers and ambulatory blood pressure patterns in African chronic kidney disease and hypertensive patients compared with normotensive controls : protocol for a longitudinal study http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14309 C and angiotensin-converting enzyme insertion and deletion polymorphisms) and biomarkers such as interleukin-6, tumor necrosis factor, soluble (s) E-selectin, homocysteine, and highly sensitive C-reactive protein have been shown to affect blood pressure variability among non-African CKD, hypertensive. and nonhypertensive CKD population. However, the contributions of the pattern, genetic, and environmental determinants of ambulatory blood pressure in African CKD have not been characterized. Understanding these interactions may help to develop interventions to prevent major cardiovascular events among people with CKD. Objective: The overarching objective of this study is to identify, document, and develop approaches to address related phenomic, genetic, and environmental determinants of ambulatory blood pressure patterns in African CKD and non-CKD hypertensive patients compared with normotensive controls. Methods: This is a longitudinal short-term follow-up study of 200 adult subjects with CKD and 200 each of age-matched hypertensives without CKD and apparently healthy controls. Demographic information, detailed clinical profile, electrocardiography, echocardiography, and 24-hr ambulatory blood pressure measurements will be obtained. Blood samples will be collected to determine albumin-creatinine ratio, fasting plasma glucose, lipid profile, electrolytes, urea and creatinine, C-reactive protein, serum homocysteine, fibroblast growth factor-23, and complete blood count, while 2 mL blood aliquot will be collected in EDTA (ethylenediaminetetraacetic acid) tubes and mixed using an electronic rolling system to prevent blood clots and subsequently used for DNA extraction and genetic analysis. Results: A total of 239 participants have been recruited so far, and it is expected that the recruitment phase will be complete in June 2020. The follow-up phase will continue with data analysis and publications of results. Conclusions: This study will help stratify Nigerian CKD patients phenotypically and genotypically in terms of their blood pressure variations with implications for targeted interventions and timing of medications to improve prognosis.]]> Thu 09 Dec 2021 15:35:02 AEDT ]]> Metabolic syndrome is associated with similar long-term prognosis in those living with and without obesity : an analysis of 45 615 patients from the nationwide LIPIDOGRAM 2004-2015 studies http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:18920 Thu 08 Feb 2024 15:23:19 AEDT ]]> The y chromosome : A blueprint for men's health? http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13014 Thu 07 Oct 2021 16:13:10 AEDT ]]> Addressing global disparities in blood pressure control : perspectives of the International Society of Hypertension http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:18147 Thu 03 Aug 2023 14:08:08 AEST ]]> Relationship between anti-DFS70 autoantibodies and oxidative stress http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17150 Mon 30 Jan 2023 13:43:48 AEDT ]]> The differences in the prevalence of cardiovascular disease, its risk factors, and achievement of therapeutic goals among urban and rural primary care patients in Poland: Results from the LIPIDOGRAM 2015 study http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15879 Mon 28 Mar 2022 13:48:05 AEDT ]]> Noncoding genes on sex chromosomes and their function in sex determination, dosage compensation, male traits, and diseases http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15869 Mon 28 Mar 2022 13:34:08 AEDT ]]> Establishment of sex difference in circulating uric acid is associated with higher testosterone and lower sex hormone-binding globulin in adolescent boys http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15335 Mon 25 Oct 2021 11:48:11 AEDT ]]> Plasma proteomics of renal function: A transethnic meta-analysis and mendelian randomization study http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15660 Mon 24 Jan 2022 14:30:29 AEDT ]]> Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15179 Mon 23 Aug 2021 11:40:02 AEST ]]> Fasting triglycerides are positively associated with cardiovascular mortality risk in people with diabetes http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:18368 Mon 18 Sep 2023 13:42:23 AEST ]]> Serum antinuclear autoantibodies are associated with measures of oxidative stress and lifestyle factors : analysis of LIPIDOGRAM2015 and LIPIDOGEN2015 studies http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:18726 Mon 18 Dec 2023 13:14:14 AEDT ]]> Plasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15041 Mon 17 May 2021 13:30:30 AEST ]]> A modified MTS proliferation assay for suspended cells to avoid the interference by hydralazine and β-Mercaptoethanol http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15171 Mon 13 Sep 2021 17:28:12 AEST ]]> Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15013 Mon 12 Apr 2021 15:22:09 AEST ]]> Adjustment for body mass index changes inverse associations of HDL-cholesterol with blood pressure and hypertension to positive associations http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:16947 Mon 11 Sep 2023 10:07:58 AEST ]]> An improved 3-(4,5-dmethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl )-2H-tetrazolium proliferation assay to overcome the interference of hydralazine http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15089 = 10 mu M) increased absorbance in a concentration-dependent manner. The modified MTS assay produced results consistent with trypan blue exclusion and microscopy. In conclusion, a simple modification of the standard MTS assay overcame the interference of hydralazine and may be useful to avoid interference from other tested compounds.]]> Mon 10 Jan 2022 15:16:15 AEDT ]]> The prevalence of cardiovascular risk factors and cardiovascular disease among primary care patients in Poland : results from the LIPIDOGRAM2015 study http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15692 80% had dyslipidaemia and <15% of patients were diagnosed with diabetes (DM). All of these disorders were more frequent in men. In 80% of patients the waist circumference exceed norm for the European population. Less than half of the patients were current smokers or had smoked in the past. Patients with CVD had significantly higher blood pressure and glucose levels but lower low density lipoprotein-cholesterol level. Conclusions: The prevalence of CVD and CV risk factors among patients in Poland is high. CVD is more common in men than in women. The most common CV risk factors are excess waist circumference, dyslipidaemia and HTN. Family physicians should conduct activities to prevent, diagnose early and treat CVD in the primary health care population. © 2021 Elsevier B.V. **Please note that there are multiple authors for this article therefore only the name of the first 5 including Federation University Australia affiliate “Fadi Charchar” is provided in this record**]]> Mon 07 Feb 2022 15:14:21 AEDT ]]> DMD-associated dilated cardiomyopathy : genotypes, phenotypes, and phenocopies http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:19065 90, indicating high levels of constitutive expression in the human adult heart. Fifteen DMD variant-negative probands (15/40: 37.5%) had variants in autosomal genes including TTN, BAG3, LMNA, and RBM20. Myocardial telomere length was reduced in patients with DCM irrespective of genotype. No differences in blood telomere length were observed between genotype-positive family members with/without DCM and controls. Conclusions: Primary genetic testing using multi-gene panels has a low yield and specific assays for structural variants are required if DMD-associated cardiomyopathy is suspected. Distinguishing X-linked causes of DCM from autosomal genes that show sex differences in clinical presentation is crucial for informed family management. © 2023 American Heart Association, Inc.]]> Mon 04 Mar 2024 12:25:11 AEDT ]]> Analysis of the impact of sex and age on the variation in the prevalence of antinuclear autoantibodies in Polish population : a nationwide observational, cross-sectional study http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:16571 Fri 22 Dec 2023 14:56:38 AEDT ]]> 2020 International Society of Hypertension global hypertension practice guidelines http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15713 Fri 03 Nov 2023 12:12:48 AEDT ]]>