http://researchonline.federation.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14837 Wed 25 Nov 2020 10:04:34 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17119 Wed 11 Jan 2023 15:37:17 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14597 Wed 07 Apr 2021 14:02:41 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14048 Wed 07 Apr 2021 14:02:08 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13780 0.1). The depressor response to pentolinium was greater in BPH/2J than BPN/3J, but in both cases the response in RD mice was similar to sham. Enalaprilat decreased MAP more in RD BPH/2J compared to sham (−12 vs −3 mmHg, P < 0.001) but had no effect in BPN/3J. RD reduced renal noradrenaline in both strains but more so in BPH/2J. RD reduced renin mRNA and protein, but not plasma renin in BPH/2J to levels comparable with BPN/3J mice. We conclude that renal nerves contribute to hypertension in BPH mice as RD induced a sustained fall in MAP, which was associated with a reduction of intrarenal renin expression. The lack of inhibition of the depressor effects of pentolinium and enalaprilat by RD suggests that vasoconstrictor effects of the SNS or RAS are not involved.]]> Wed 07 Apr 2021 14:01:53 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13408 Wed 07 Apr 2021 14:01:33 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13406 Wed 07 Apr 2021 14:01:33 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13342 Wed 07 Apr 2021 14:01:30 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:12972 Wed 07 Apr 2021 14:01:10 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:12914 7 mg/dL in men and >6 mg/dL in women. The association between sUA concentration and SBP and DBP was examined using Pearson's correlation test, multivariate linear regression, and logistic regression analysis. The prevalence of hypertension and HUA increased with age (P < .001). Hypertension was more common in participants that had HUA than in those that did not (38.95% vs 30.16%, P = .02). Higher sUA was significantly associated with higher SBP and DBP in the 41- to 50-year-old participants (SBP, β = 0.35, P < .001; DBP, β = .29, P < .001; after adjustment for age, sex, total cholesterol, estimated glomerular filtration rate, and fasting plasma glucose). HUA was also a risk factor for hypertension in this age group (odds ratio 1.425, 95% confidence interval, 1.217-1.668, P < .001). There was no association between sUA concentration and SBP and DBP in the other age groups. In this population of healthy Chinese participants, sUA concentration was positively associated with hypertension only in the 41- to 50-year-old group. Lowering uric acid in this age group may help to reduce the incidence of hypertension.]]> Wed 07 Apr 2021 14:01:07 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:12206 Wed 07 Apr 2021 14:00:30 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10710 Wed 07 Apr 2021 13:56:03 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10534 Wed 07 Apr 2021 13:55:52 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10341 Wed 07 Apr 2021 13:55:41 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10127 Wed 07 Apr 2021 13:55:26 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:9618 Wed 07 Apr 2021 13:54:52 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:7659 Wed 07 Apr 2021 13:47:08 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6926 Wed 07 Apr 2021 13:46:28 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5740 Wed 07 Apr 2021 13:45:18 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5088 Wed 07 Apr 2021 13:44:42 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:4861 Wed 07 Apr 2021 13:44:25 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:4583 Wed 07 Apr 2021 13:44:04 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:4560 Wed 07 Apr 2021 13:44:02 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:4524 Wed 07 Apr 2021 13:43:59 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:4523 Wed 07 Apr 2021 13:43:59 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:4265 Wed 07 Apr 2021 13:43:42 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:4256 Wed 07 Apr 2021 13:43:42 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:4075 Wed 07 Apr 2021 13:43:24 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:3688 Wed 07 Apr 2021 13:34:42 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:2909 Wed 07 Apr 2021 13:33:56 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:2883 Wed 07 Apr 2021 13:33:54 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:184 Wed 07 Apr 2021 13:31:02 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17162 Tue 31 Jan 2023 10:29:50 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14703 = 18 years) recruited through opportunistic sampling were screened at sites in 92 countries during May 2019. Ideally, 3 blood pressure readings were measured for each participant, and data on lifestyle factors and comorbidities were collected. Hypertension was defined as a systolic blood pressure >= 140 mm Hg, or a diastolic blood pressure >= 90 mm Hg (mean of the second and third readings) or taking antihypertensive medication. When necessary, multiple imputation was used to estimate participants' mean blood pressure. Mixed-effects models were used to evaluate associations between blood pressure and participant characteristics. Of 1 508 130 screenees 482 273 (32.0%) had never had a blood pressure measurement before and 513 337 (34.0%) had hypertension, of whom 58.7% were aware, and 54.7% were on antihypertensive medication. Of those on medication, 57.8% were controlled to <140/90 mm Hg, and 28.9% to <130/80 mm Hg. Of all those with hypertension, 31.7% were controlled to <140/90 mm Hg, and 350 825 (23.3%) participants had untreated or inadequately treated hypertension. Of those taking antihypertensive medication, half were taking only a single drug, and 25% reported using aspirin inappropriately. This survey is the largest ever synchronized and standardized contemporary compilation of global blood pressure data. This campaign is needed as a temporary substitute for systematic blood pressure screening in many countries worldwide.]]> Tue 19 Oct 2021 16:23:32 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13276 Tue 19 Oct 2021 11:50:57 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:12377 Tue 19 Mar 2024 11:38:09 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17626 Tue 09 May 2023 12:01:48 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14938 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency ≤ 0.01) variant BP associations (P < 5 × 10−8), of which 32 were in new BP-associated loci and 55 were independent BP-associated single-nucleotide variants within known BP-associated regions. Average effects of rare variants (44% coding) were ~8 times larger than common variant effects and indicate potential candidate causal genes at new and known loci (for example, GATA5 and PLCB3). BP-associated variants (including rare and common) were enriched in regions of active chromatin in fetal tissues, potentially linking fetal development with BP regulation in later life. Multivariable Mendelian randomization suggested possible inverse effects of elevated systolic and diastolic BP on large artery stroke. Our study demonstrates the utility of rare-variant analyses for identifying candidate genes and the results highlight potential therapeutic targets. © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. There are 286 authors of this articles not all are listed in this record.]]> Thu 25 Nov 2021 11:48:02 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15861 Thu 24 Mar 2022 11:20:04 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:18750 140 mmHg and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of Hypertension guidelines), affects over 1.5 billion people worldwide. Hypertension is associated with increased risk of cardiovascular disease (CVD) events (e.g. coronary heart disease, heart failure and stroke) and death. An international panel of experts convened by the International Society of Hypertension College of Experts compiled lifestyle management recommendations as first-line strategy to prevent and control hypertension in adulthood. We also recommend that lifestyle changes be continued even when blood pressure-lowering medications are prescribed. Specific recommendations based on literature evidence are summarized with advice to start these measures early in life, including maintaining a healthy body weight, increased levels of different types of physical activity, healthy eating and drinking, avoidance and cessation of smoking and alcohol use, management of stress and sleep levels. We also discuss the relevance of specific approaches including consumption of sodium, potassium, sugar, fibre, coffee, tea, intermittent fasting as well as integrated strategies to implement these recommendations using, for example, behaviour change-related technologies and digital tools. **Please note that there are multiple authors for this article therefore only the name of the first 30 including Federation University Australia affiliates “Fadi Charchar, Priscilla Prestes, Britt Klein, Colette Browning, Olutope Akinnibosun and Shane Thomas” are provided in this record**]]> Thu 18 Jan 2024 11:16:43 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:18147 Thu 03 Aug 2023 14:08:08 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14907 Mon 21 Dec 2020 14:32:49 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17543 Mon 17 Apr 2023 10:21:14 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17246 Mon 13 Feb 2023 10:53:07 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15013 Mon 12 Apr 2021 15:22:09 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17284 Mon 11 Sep 2023 10:00:35 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15692 80% had dyslipidaemia and <15% of patients were diagnosed with diabetes (DM). All of these disorders were more frequent in men. In 80% of patients the waist circumference exceed norm for the European population. Less than half of the patients were current smokers or had smoked in the past. Patients with CVD had significantly higher blood pressure and glucose levels but lower low density lipoprotein-cholesterol level. Conclusions: The prevalence of CVD and CV risk factors among patients in Poland is high. CVD is more common in men than in women. The most common CV risk factors are excess waist circumference, dyslipidaemia and HTN. Family physicians should conduct activities to prevent, diagnose early and treat CVD in the primary health care population. © 2021 Elsevier B.V. **Please note that there are multiple authors for this article therefore only the name of the first 5 including Federation University Australia affiliate “Fadi Charchar” is provided in this record**]]> Mon 07 Feb 2022 15:14:21 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17394 Mon 06 Mar 2023 11:56:12 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:18223 Fri 18 Aug 2023 13:01:15 AEST ]]>