http://researchonline.federation.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 Neural suppression of miRNA-181a in the kidney elevates renin expression and exacerbates hypertension in Schlager mice http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14837 Wed 25 Nov 2020 10:04:34 AEDT ]]> May measurement month 2018 : A pragmatic global screening campaign to raise awareness of blood pressure by the international society of hypertension http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14048 Wed 07 Apr 2021 14:02:08 AEST ]]> Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13808 Wed 07 Apr 2021 14:01:55 AEST ]]> Renal nerves contribute to hypertension in Schlager BPH/2J mice http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13780 0.1). The depressor response to pentolinium was greater in BPH/2J than BPN/3J, but in both cases the response in RD mice was similar to sham. Enalaprilat decreased MAP more in RD BPH/2J compared to sham (−12 vs −3 mmHg, P < 0.001) but had no effect in BPN/3J. RD reduced renal noradrenaline in both strains but more so in BPH/2J. RD reduced renin mRNA and protein, but not plasma renin in BPH/2J to levels comparable with BPN/3J mice. We conclude that renal nerves contribute to hypertension in BPH mice as RD induced a sustained fall in MAP, which was associated with a reduction of intrarenal renin expression. The lack of inhibition of the depressor effects of pentolinium and enalaprilat by RD suggests that vasoconstrictor effects of the SNS or RAS are not involved.]]> Wed 07 Apr 2021 14:01:53 AEST ]]> Genetics of blood pressure : Time to curate the collection http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11640 Wed 07 Apr 2021 13:56:56 AEST ]]> Genetic variation within the Y chromosome is not associated with histological characteristics of the atherosclerotic carotid artery or aneurysmal wall http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11392 Wed 07 Apr 2021 13:56:42 AEST ]]> Tripartite motif-containing 55 identified as functional candidate for spontaneous cardiac hypertrophy in the rat locus cardiac mass 22 http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10751 Wed 07 Apr 2021 13:56:06 AEST ]]> Renal Mechanisms of Association between Fibroblast Growth Factor 1 and Blood Pressure http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10534 Wed 07 Apr 2021 13:55:52 AEST ]]> A multi-omics glimpse into the biology of arterial stiffness http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10341 Wed 07 Apr 2021 13:55:41 AEST ]]> The emerging role of non-coding RNA in essential hypertension and blood pressure regulation http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10127 Wed 07 Apr 2021 13:55:26 AEST ]]> Coronary artery disease predisposing haplogroup I of the Y chromosome, aggression and sex steroids - Genetic association analysis http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:9603 1000 young apparently healthy white men from the general population. Each Y chromosome was classified into one of 13 most common European lineages. Androgens (DHEA-S, androstenedione, total testosterone) and their metabolites (total estradiol, estrone) were measured by radioimmunoassays. Information on five dimensions of aggression (total, physical, verbal, anger and hostility) was collected using Buss and Perry questionnaire. Results: Approximately 17% men inherited haplogroup I from their fathers. Carriers of haplogroup I showed lower scores of verbal aggression than men with other haplogroups (beta = -0.72, SE = 0.29, P = 0.012) and when further compared to carriers of most common R1a lineage and other haplogroups (beta = -1.03, SE = 0.34, P = 0.003). However, these associations did not survive a correction for multiple testing. Sex steroids did not show even nominal level of association with haplogroup I. Conclusion: Our data show no overall association between haplogroup I and sex-related phenotypes in young white men. These results also suggest that the previously identified association between haplogroup I and coronary artery disease is not likely mediated by unfavourable profile of sex steroids or heightened aggression early in life. (C) 2014 Elsevier Ireland Ltd. All rights reserved.]]> Wed 07 Apr 2021 13:54:51 AEST ]]> Report of the 3rd annual International Society of Hypertension New Investigator Symposium. http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:7659 Wed 07 Apr 2021 13:47:08 AEST ]]> 121 Telomere attrition is attenuated in ultra-marathon runners http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:7167 Wed 07 Apr 2021 13:46:40 AEST ]]> The acute effects of intense cardiorespiratory exercise on human telomerase reverse transcriptase and sirtuin 6 expression in white blood cells http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:7161 Wed 07 Apr 2021 13:46:39 AEST ]]> A novel interaction between sympathetic overactivity and aberrant regulation of renin by miR-181a in BPH/2J genetically hypertensive mice http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6926 Wed 07 Apr 2021 13:46:28 AEST ]]> Leading the change: Second International Society of Hypertension New Investigators' Symposium http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5401 Wed 07 Apr 2021 13:45:02 AEST ]]> Up-regulation of autophagic pathways early in life might contribute to cardiac hypertrophy in a heritable polygenic model http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5379 Wed 07 Apr 2021 13:45:01 AEST ]]> Novel insights into essential hypertension etiology revealed by genome-wide gene expression profiling of human kidneys: evidence for renin involvement via a microRNA-mediated effect on expression http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5378 Wed 07 Apr 2021 13:45:01 AEST ]]> Early treatment to prevent hypertension: A laudable goal http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5368 Wed 07 Apr 2021 13:45:00 AEST ]]> Genetic mechanisms of vascular and renal damage http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5261 Wed 07 Apr 2021 13:44:54 AEST ]]> Male-specific region of the y chromosome and cardiovascular risk phylogenetic analysis and gene expression studies http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5099 Wed 07 Apr 2021 13:44:43 AEST ]]> Pathway analysis shows association between FGFBP1 and hypertension http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:4075 Wed 07 Apr 2021 13:43:24 AEST ]]> Genetic architecture of ambulatory blood pressure in the general population insights from cardiovascular gene-centric array http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:3910 2000 cardiovascular candidate loci. We found a strong association between rs13306560 polymorphism in the promoter region of MTHFR and CLCN6 and mean 24-hour diastolic blood pressure; each minor allele copy of rs13306560 was associated with 2.6 mm Hg lower mean 24-hour diastolic blood pressure (P=1.2 x 10(-8)). rs13306560 was also associated with clinic diastolic blood pressure in a combined analysis of 8129 subjects from the Genetic Regulation of Arterial Pressure of Humans in the Community Study, the CoLaus Study, and the Silesian Cardiovascular Study (P=5.4 x 10(-6)). Additional analysis of associations between variants in gene ontology-defined pathways and mean 24-hour blood pressure in the Genetic Regulation of Arterial Pressure of Humans in the Community Study showed that cell survival control signaling cascades could play a role in blood pressure regulation. There was also a significant overrepresentation of rare variants (minor allele frequency: <0.05) among polymorphisms showing at least nominal association with mean 24-hour blood pressure indicating that a considerable proportion of its heritability may be explained by uncommon alleles. Through a large-scale gene-centric analysis of ambulatory blood pressure, we identified an association of a novel variant at the MTHFR/CLNC6 locus with diastolic blood pressure and provided new insights into the genetic architecture of blood pressure.]]> Wed 07 Apr 2021 13:34:57 AEST ]]> Whole genome survey of copy number variation in the spontaneously hypertensive rat relationship to quantitative trait loci, gene expression, and blood pressure http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:2909 Wed 07 Apr 2021 13:33:56 AEST ]]> Orthologues of GSTM expressed in human kidney http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:2460 Wed 07 Apr 2021 13:33:32 AEST ]]> Strikingly low circulating CRP concentrations in ultramarathon runners independent of markers of adiposity - How low can you go? http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:2459 Wed 07 Apr 2021 13:33:32 AEST ]]> Cardiovascular diseases and G-protein beta 3 subunit gene (GNB3) in the era of genomewide scans http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:2458 Wed 07 Apr 2021 13:33:32 AEST ]]> Common allelic variant in the gene underlying rare monogenic form of coronary artery disease cosegregates with elevated LDL cholesterol in families with high cardiovascular risk http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:890 Wed 07 Apr 2021 13:31:52 AEST ]]> Whole genome survey of copy number variation in the spontaneously hypertensive rat http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:184 Wed 07 Apr 2021 13:31:02 AEST ]]> May measurement month 2019 the global blood pressure screening campaign of the International Society of Hypertension http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14703 = 18 years) recruited through opportunistic sampling were screened at sites in 92 countries during May 2019. Ideally, 3 blood pressure readings were measured for each participant, and data on lifestyle factors and comorbidities were collected. Hypertension was defined as a systolic blood pressure >= 140 mm Hg, or a diastolic blood pressure >= 90 mm Hg (mean of the second and third readings) or taking antihypertensive medication. When necessary, multiple imputation was used to estimate participants' mean blood pressure. Mixed-effects models were used to evaluate associations between blood pressure and participant characteristics. Of 1 508 130 screenees 482 273 (32.0%) had never had a blood pressure measurement before and 513 337 (34.0%) had hypertension, of whom 58.7% were aware, and 54.7% were on antihypertensive medication. Of those on medication, 57.8% were controlled to <140/90 mm Hg, and 28.9% to <130/80 mm Hg. Of all those with hypertension, 31.7% were controlled to <140/90 mm Hg, and 350 825 (23.3%) participants had untreated or inadequately treated hypertension. Of those taking antihypertensive medication, half were taking only a single drug, and 25% reported using aspirin inappropriately. This survey is the largest ever synchronized and standardized contemporary compilation of global blood pressure data. This campaign is needed as a temporary substitute for systematic blood pressure screening in many countries worldwide.]]> Tue 19 Oct 2021 16:23:32 AEDT ]]> Hyperuricemia is independently associated with hypertension in men under 60 years in a general Chinese population http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15666 Tue 18 Jan 2022 14:45:24 AEDT ]]> Secondary stroke prevention in polish adults: Results from the lipidogram2015 study http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15735 Thu 24 Feb 2022 09:28:04 AEDT ]]> Human Y Chromosome Exerts Pleiotropic Effects on Susceptibility to Atherosclerosis http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14223 Thu 19 May 2022 12:38:25 AEST ]]> 2020 International Society of Hypertension global hypertension practice guidelines http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14617 Thu 19 May 2022 12:02:09 AEST ]]> The association between selected molecular biomarkers and ambulatory blood pressure patterns in African chronic kidney disease and hypertensive patients compared with normotensive controls : protocol for a longitudinal study http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14309 C and angiotensin-converting enzyme insertion and deletion polymorphisms) and biomarkers such as interleukin-6, tumor necrosis factor, soluble (s) E-selectin, homocysteine, and highly sensitive C-reactive protein have been shown to affect blood pressure variability among non-African CKD, hypertensive. and nonhypertensive CKD population. However, the contributions of the pattern, genetic, and environmental determinants of ambulatory blood pressure in African CKD have not been characterized. Understanding these interactions may help to develop interventions to prevent major cardiovascular events among people with CKD. Objective: The overarching objective of this study is to identify, document, and develop approaches to address related phenomic, genetic, and environmental determinants of ambulatory blood pressure patterns in African CKD and non-CKD hypertensive patients compared with normotensive controls. Methods: This is a longitudinal short-term follow-up study of 200 adult subjects with CKD and 200 each of age-matched hypertensives without CKD and apparently healthy controls. Demographic information, detailed clinical profile, electrocardiography, echocardiography, and 24-hr ambulatory blood pressure measurements will be obtained. Blood samples will be collected to determine albumin-creatinine ratio, fasting plasma glucose, lipid profile, electrolytes, urea and creatinine, C-reactive protein, serum homocysteine, fibroblast growth factor-23, and complete blood count, while 2 mL blood aliquot will be collected in EDTA (ethylenediaminetetraacetic acid) tubes and mixed using an electronic rolling system to prevent blood clots and subsequently used for DNA extraction and genetic analysis. Results: A total of 239 participants have been recruited so far, and it is expected that the recruitment phase will be complete in June 2020. The follow-up phase will continue with data analysis and publications of results. Conclusions: This study will help stratify Nigerian CKD patients phenotypically and genotypically in terms of their blood pressure variations with implications for targeted interventions and timing of medications to improve prognosis.]]> Thu 09 Dec 2021 15:35:02 AEDT ]]> The y chromosome : A blueprint for men's health? http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13014 Thu 07 Oct 2021 16:13:10 AEDT ]]> Plasma proteomics of renal function: A transethnic meta-analysis and mendelian randomization study http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15660 Mon 24 Jan 2022 14:30:29 AEDT ]]> Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15013 Mon 12 Apr 2021 15:22:09 AEST ]]> The prevalence of cardiovascular risk factors and cardiovascular disease among primary care patients in Poland : results from the LIPIDOGRAM2015 study http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15692 80% had dyslipidaemia and <15% of patients were diagnosed with diabetes (DM). All of these disorders were more frequent in men. In 80% of patients the waist circumference exceed norm for the European population. Less than half of the patients were current smokers or had smoked in the past. Patients with CVD had significantly higher blood pressure and glucose levels but lower low density lipoprotein-cholesterol level. Conclusions: The prevalence of CVD and CV risk factors among patients in Poland is high. CVD is more common in men than in women. The most common CV risk factors are excess waist circumference, dyslipidaemia and HTN. Family physicians should conduct activities to prevent, diagnose early and treat CVD in the primary health care population. © 2021 Elsevier B.V. **Please note that there are multiple authors for this article therefore only the name of the first 5 including Federation University Australia affiliate “Fadi Charchar” is provided in this record**]]> Mon 07 Feb 2022 15:14:21 AEDT ]]> Association between lipid profile and circulating concentrations of estrogens in young men http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5174 Fri 30 Apr 2021 15:48:56 AEST ]]> 2020 International Society of Hypertension global hypertension practice guidelines http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15713 Fri 03 Nov 2023 12:12:48 AEDT ]]>