http://researchonline.federation.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 Body mass index is negatively associated with telomere length : A collaborative cross-sectional meta-analysis of 87 observational studies http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13493 75 y), sex, and ethnicity. Results: Each unit increase in BMI corresponded to a-3.99 bp (95% CI: -5.17, -2.81 bp) difference in TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a -7.67 bp (95% CI:-10.03,-5.31 bp) difference. Each unit increase in BMI corresponded to a -1.58 × 10-3 unit T/S ratio (0.16% decrease; 95% CI: -2.14 × 10-3, -1.01 × 10-3) difference in ageand sex-adjusted relative TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a -2.58 × 10-3 unit T/S ratio (0.26% decrease; 95% CI: -3.92 × 10-3, -1.25 × 10-3). The associations were predominantly for the white pooled population. No sex differences were observed. Conclusions: A higher BMI is associated with shorter telomeres, especially in younger individuals. The presently observed difference is not negligible. Meta-analyses of longitudinal studies evaluating change in body weight alongside change in TL arewarranted.]]> Wed 07 Apr 2021 14:01:37 AEST ]]> Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10894 Wed 07 Apr 2021 13:56:16 AEST ]]> Increased expression of telomere-regulating genes in endurance athletes with long leukocyte telomeres http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10529 0.05). Resting heart rate emerged as an independent predictor of leukocyte telomere length and TERT and TPP1 mRNA expression in stepwise regression models. To gauge whether volume of exercise was associated with leukocyte telomere length, we divided subjects into running and cycling tertiles (distance covered per week) and found individuals in the middle and highest tertiles had longer telomeres than individuals in the lowest tertile. These data emphasize the importance of cardiorespiratory fitness and exercise training in the prevention of biological aging. They also support the concept that moderate amounts of exercise training protects against biological aging, while higher amounts may not elicit additional benefits.]]> Wed 07 Apr 2021 13:55:51 AEST ]]> Runs of Homozygosity : Association with Coronary Artery Disease and Gene Expression in Monocytes and Macrophages http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10162 Wed 07 Apr 2021 13:55:29 AEST ]]> Changes in the leukocyte methylome and its effect on cardiovascular-related genes after exercise http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:7624 Wed 07 Apr 2021 13:47:06 AEST ]]> Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5239 Wed 07 Apr 2021 13:44:53 AEST ]]> RNA sequencing data from the human kidney http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:4943 Wed 07 Apr 2021 13:44:32 AEST ]]> Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14938 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency ≤ 0.01) variant BP associations (P < 5 × 10−8), of which 32 were in new BP-associated loci and 55 were independent BP-associated single-nucleotide variants within known BP-associated regions. Average effects of rare variants (44% coding) were ~8 times larger than common variant effects and indicate potential candidate causal genes at new and known loci (for example, GATA5 and PLCB3). BP-associated variants (including rare and common) were enriched in regions of active chromatin in fetal tissues, potentially linking fetal development with BP regulation in later life. Multivariable Mendelian randomization suggested possible inverse effects of elevated systolic and diastolic BP on large artery stroke. Our study demonstrates the utility of rare-variant analyses for identifying candidate genes and the results highlight potential therapeutic targets. © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. There are 286 authors of this articles not all are listed in this record.]]> Thu 25 Nov 2021 11:48:02 AEDT ]]> Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15179 Mon 23 Aug 2021 11:40:02 AEST ]]>