http://researchonline.federation.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14597 Wed 07 Apr 2021 14:02:41 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14048 Wed 07 Apr 2021 14:02:08 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13808 Wed 07 Apr 2021 14:01:55 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13780 0.1). The depressor response to pentolinium was greater in BPH/2J than BPN/3J, but in both cases the response in RD mice was similar to sham. Enalaprilat decreased MAP more in RD BPH/2J compared to sham (−12 vs −3 mmHg, P < 0.001) but had no effect in BPN/3J. RD reduced renal noradrenaline in both strains but more so in BPH/2J. RD reduced renin mRNA and protein, but not plasma renin in BPH/2J to levels comparable with BPN/3J mice. We conclude that renal nerves contribute to hypertension in BPH mice as RD induced a sustained fall in MAP, which was associated with a reduction of intrarenal renin expression. The lack of inhibition of the depressor effects of pentolinium and enalaprilat by RD suggests that vasoconstrictor effects of the SNS or RAS are not involved.]]> Wed 07 Apr 2021 14:01:53 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13698 Wed 07 Apr 2021 14:01:48 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13680 Wed 07 Apr 2021 14:01:47 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13538 Wed 07 Apr 2021 14:01:40 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13241 Wed 07 Apr 2021 14:01:24 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:12993 Wed 07 Apr 2021 14:01:11 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:12206 Wed 07 Apr 2021 14:00:30 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11958 Wed 07 Apr 2021 13:57:15 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11963 Wed 07 Apr 2021 13:57:15 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11116 Wed 07 Apr 2021 13:56:26 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11075 Wed 07 Apr 2021 13:56:24 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10751 Wed 07 Apr 2021 13:56:06 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10738 Wed 07 Apr 2021 13:56:05 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10609 Wed 07 Apr 2021 13:55:57 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10546 Wed 07 Apr 2021 13:55:53 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10534 Wed 07 Apr 2021 13:55:52 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10525 Wed 07 Apr 2021 13:55:51 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10529 0.05). Resting heart rate emerged as an independent predictor of leukocyte telomere length and TERT and TPP1 mRNA expression in stepwise regression models. To gauge whether volume of exercise was associated with leukocyte telomere length, we divided subjects into running and cycling tertiles (distance covered per week) and found individuals in the middle and highest tertiles had longer telomeres than individuals in the lowest tertile. These data emphasize the importance of cardiorespiratory fitness and exercise training in the prevention of biological aging. They also support the concept that moderate amounts of exercise training protects against biological aging, while higher amounts may not elicit additional benefits.]]> Wed 07 Apr 2021 13:55:51 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10451 Wed 07 Apr 2021 13:55:49 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:9618 Wed 07 Apr 2021 13:54:52 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6933 Wed 07 Apr 2021 13:46:28 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6459 Wed 07 Apr 2021 13:46:03 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5804 Wed 07 Apr 2021 13:45:22 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5740 Wed 07 Apr 2021 13:45:18 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5239 Wed 07 Apr 2021 13:44:53 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5126 Wed 07 Apr 2021 13:44:45 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5099 Wed 07 Apr 2021 13:44:43 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5088 Wed 07 Apr 2021 13:44:42 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14995 Wed 07 Apr 2021 13:24:57 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17325 Tue 28 Feb 2023 14:32:09 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:19129 Tue 26 Mar 2024 15:15:11 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17011 Tue 20 Dec 2022 15:35:27 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14703 = 18 years) recruited through opportunistic sampling were screened at sites in 92 countries during May 2019. Ideally, 3 blood pressure readings were measured for each participant, and data on lifestyle factors and comorbidities were collected. Hypertension was defined as a systolic blood pressure >= 140 mm Hg, or a diastolic blood pressure >= 90 mm Hg (mean of the second and third readings) or taking antihypertensive medication. When necessary, multiple imputation was used to estimate participants' mean blood pressure. Mixed-effects models were used to evaluate associations between blood pressure and participant characteristics. Of 1 508 130 screenees 482 273 (32.0%) had never had a blood pressure measurement before and 513 337 (34.0%) had hypertension, of whom 58.7% were aware, and 54.7% were on antihypertensive medication. Of those on medication, 57.8% were controlled to <140/90 mm Hg, and 28.9% to <130/80 mm Hg. Of all those with hypertension, 31.7% were controlled to <140/90 mm Hg, and 350 825 (23.3%) participants had untreated or inadequately treated hypertension. Of those taking antihypertensive medication, half were taking only a single drug, and 25% reported using aspirin inappropriately. This survey is the largest ever synchronized and standardized contemporary compilation of global blood pressure data. This campaign is needed as a temporary substitute for systematic blood pressure screening in many countries worldwide.]]> Tue 19 Oct 2021 16:23:32 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13276 Tue 19 Oct 2021 11:50:57 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:18803 Tue 16 Jan 2024 15:08:09 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17626 Tue 09 May 2023 12:01:48 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14938 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency ≤ 0.01) variant BP associations (P < 5 × 10−8), of which 32 were in new BP-associated loci and 55 were independent BP-associated single-nucleotide variants within known BP-associated regions. Average effects of rare variants (44% coding) were ~8 times larger than common variant effects and indicate potential candidate causal genes at new and known loci (for example, GATA5 and PLCB3). BP-associated variants (including rare and common) were enriched in regions of active chromatin in fetal tissues, potentially linking fetal development with BP regulation in later life. Multivariable Mendelian randomization suggested possible inverse effects of elevated systolic and diastolic BP on large artery stroke. Our study demonstrates the utility of rare-variant analyses for identifying candidate genes and the results highlight potential therapeutic targets. © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. There are 286 authors of this articles not all are listed in this record.]]> Thu 25 Nov 2021 11:48:02 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15857 Thu 24 Mar 2022 10:38:04 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15735 Thu 24 Feb 2022 09:28:04 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17466 1000 common and rare genetic variants associated with BP and/or hypertension. The kidney is not only an organ of key relevance to BP regulation and the development of hypertension, but it also acts as the tissue mediator of genetic predisposition to hypertension. The identity of kidney genes, pathways, and related mechanisms underlying the genetic associations with BP has started to emerge through integration of genomics with kidney transcriptomics, epigenomics, and other omics as well as through applications of causal inference, such as Mendelian randomization. Single-cell methods further enabled mapping of BP-associated kidney genes to cell types, and in conjunction with other omics, started to illuminate the biological mechanisms underpinning associations of BP-associated genetic variants and kidney genes. Polygenic risk scores derived from genome-wide association studies and refined on kidney omics hold the promise of enhanced diagnostic prediction, whereas kidney omics-informed drug discovery is likely to contribute new therapeutic opportunities for hypertension and hypertension-mediated kidney damage. © 2022 International Society of Nephrology]]> Thu 23 Mar 2023 11:55:08 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14247 Thu 20 May 2021 10:20:30 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14223 Thu 19 May 2022 12:38:25 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14617 Thu 19 May 2022 12:02:09 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13555 100 loci of chronic kidney disease-defining traits (CKD-dt). Molecular mechanisms underlying these associations remain elusive. Using 280 kidney transcriptomes and 9958 gene expression profiles from 44 non-renal tissues we uncover gene expression partners (eGenes) for 88.9% of CKD-dt GWAS loci. Through epigenomic chromatin segmentation analysis and variant effect prediction we annotate functional consequences to 74% of these loci. Our colocalisation analysis and Mendelian randomisation in >130,000 subjects demonstrate causal effects of three eGenes (NAT8B, CASP9 and MUC1) on estimated glomerular filtration rate. We identify a common alternative splice variant in MUC1 (a gene responsible for rare Mendelian form of kidney disease) and observe increased renal expression of a specific MUC1 mRNA isoform as a plausible molecular mechanism of the GWAS association signal. These data highlight the variants and genes underpinning the associations uncovered in GWAS of CKD-dt.]]> Thu 19 May 2022 11:08:51 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:18750 140 mmHg and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of Hypertension guidelines), affects over 1.5 billion people worldwide. Hypertension is associated with increased risk of cardiovascular disease (CVD) events (e.g. coronary heart disease, heart failure and stroke) and death. An international panel of experts convened by the International Society of Hypertension College of Experts compiled lifestyle management recommendations as first-line strategy to prevent and control hypertension in adulthood. We also recommend that lifestyle changes be continued even when blood pressure-lowering medications are prescribed. Specific recommendations based on literature evidence are summarized with advice to start these measures early in life, including maintaining a healthy body weight, increased levels of different types of physical activity, healthy eating and drinking, avoidance and cessation of smoking and alcohol use, management of stress and sleep levels. We also discuss the relevance of specific approaches including consumption of sodium, potassium, sugar, fibre, coffee, tea, intermittent fasting as well as integrated strategies to implement these recommendations using, for example, behaviour change-related technologies and digital tools. **Please note that there are multiple authors for this article therefore only the name of the first 30 including Federation University Australia affiliates “Fadi Charchar, Priscilla Prestes, Britt Klein, Colette Browning, Olutope Akinnibosun and Shane Thomas” are provided in this record**]]> Thu 18 Jan 2024 11:16:43 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:19226 Thu 18 Apr 2024 15:33:17 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14309 C and angiotensin-converting enzyme insertion and deletion polymorphisms) and biomarkers such as interleukin-6, tumor necrosis factor, soluble (s) E-selectin, homocysteine, and highly sensitive C-reactive protein have been shown to affect blood pressure variability among non-African CKD, hypertensive. and nonhypertensive CKD population. However, the contributions of the pattern, genetic, and environmental determinants of ambulatory blood pressure in African CKD have not been characterized. Understanding these interactions may help to develop interventions to prevent major cardiovascular events among people with CKD. Objective: The overarching objective of this study is to identify, document, and develop approaches to address related phenomic, genetic, and environmental determinants of ambulatory blood pressure patterns in African CKD and non-CKD hypertensive patients compared with normotensive controls. Methods: This is a longitudinal short-term follow-up study of 200 adult subjects with CKD and 200 each of age-matched hypertensives without CKD and apparently healthy controls. Demographic information, detailed clinical profile, electrocardiography, echocardiography, and 24-hr ambulatory blood pressure measurements will be obtained. Blood samples will be collected to determine albumin-creatinine ratio, fasting plasma glucose, lipid profile, electrolytes, urea and creatinine, C-reactive protein, serum homocysteine, fibroblast growth factor-23, and complete blood count, while 2 mL blood aliquot will be collected in EDTA (ethylenediaminetetraacetic acid) tubes and mixed using an electronic rolling system to prevent blood clots and subsequently used for DNA extraction and genetic analysis. Results: A total of 239 participants have been recruited so far, and it is expected that the recruitment phase will be complete in June 2020. The follow-up phase will continue with data analysis and publications of results. Conclusions: This study will help stratify Nigerian CKD patients phenotypically and genotypically in terms of their blood pressure variations with implications for targeted interventions and timing of medications to improve prognosis.]]> Thu 09 Dec 2021 15:35:02 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13014 Thu 07 Oct 2021 16:13:10 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:18147 Thu 03 Aug 2023 14:08:08 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17150 Mon 30 Jan 2023 13:43:48 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15879 Mon 28 Mar 2022 13:48:05 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15869 Mon 28 Mar 2022 13:34:08 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15335 Mon 25 Oct 2021 11:48:11 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15660 Mon 24 Jan 2022 14:30:29 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:18368 Mon 18 Sep 2023 13:42:23 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:18726 Mon 18 Dec 2023 13:14:14 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15041 Mon 17 May 2021 13:30:30 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15171 Mon 13 Sep 2021 17:28:12 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15013 Mon 12 Apr 2021 15:22:09 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:16947 Mon 11 Sep 2023 10:07:58 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15089 = 10 mu M) increased absorbance in a concentration-dependent manner. The modified MTS assay produced results consistent with trypan blue exclusion and microscopy. In conclusion, a simple modification of the standard MTS assay overcame the interference of hydralazine and may be useful to avoid interference from other tested compounds.]]> Mon 10 Jan 2022 15:16:15 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15692 80% had dyslipidaemia and <15% of patients were diagnosed with diabetes (DM). All of these disorders were more frequent in men. In 80% of patients the waist circumference exceed norm for the European population. Less than half of the patients were current smokers or had smoked in the past. Patients with CVD had significantly higher blood pressure and glucose levels but lower low density lipoprotein-cholesterol level. Conclusions: The prevalence of CVD and CV risk factors among patients in Poland is high. CVD is more common in men than in women. The most common CV risk factors are excess waist circumference, dyslipidaemia and HTN. Family physicians should conduct activities to prevent, diagnose early and treat CVD in the primary health care population. © 2021 Elsevier B.V. **Please note that there are multiple authors for this article therefore only the name of the first 5 including Federation University Australia affiliate “Fadi Charchar” is provided in this record**]]> Mon 07 Feb 2022 15:14:21 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:19065 90, indicating high levels of constitutive expression in the human adult heart. Fifteen DMD variant-negative probands (15/40: 37.5%) had variants in autosomal genes including TTN, BAG3, LMNA, and RBM20. Myocardial telomere length was reduced in patients with DCM irrespective of genotype. No differences in blood telomere length were observed between genotype-positive family members with/without DCM and controls. Conclusions: Primary genetic testing using multi-gene panels has a low yield and specific assays for structural variants are required if DMD-associated cardiomyopathy is suspected. Distinguishing X-linked causes of DCM from autosomal genes that show sex differences in clinical presentation is crucial for informed family management. © 2023 American Heart Association, Inc.]]> Mon 04 Mar 2024 12:25:11 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:16571 Fri 22 Dec 2023 14:56:38 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15713 Fri 03 Nov 2023 12:12:48 AEDT ]]>