http://researchonline.federation.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11240 Wed 07 Apr 2021 13:56:34 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:8257 thymocytes/natural killer (NK) cells>peripheral T cells. Within thymocyte populations, GICD sensitivity decreased with maturation. Interestingly, NK cell subsets were differentially sensitive to GICD, with CD16 + CD56 int (cytotoxic) NK cells being highly resistant to GICD, whereas CD16-CD56 hi (cytokine producing) NK cells were highly sensitive (similar to B cells). B-cell GICD was rescued by co-culture with interleukin-4. Strikingly, although no significant increases in GR protein were observed during 48 h of culture of GICD-sensitive and-resistant cells alike, GR 1A3 expression was increased over pre-culture levels in a manner directly proportional to the GICD sensitivity of each cell type. Accordingly, this is the first evidence that the GR exon 1A3 promoter is differentially regulated during thymic development and maturation of human T cells. Furthermore, human peripheral blood B cells are exquisitely GICD-sensitive in vitro, giving new insight into how GCs may downregulate immunity. Collectively, these data show that GR 1A3 expression is tied with GICD sensitivity in human lymphocytes, underscoring the potential for GR 1A3 expression to be used as a biomarker for sensitivity to GICD. © 2014 Australasian Society for Immunology Inc.]]> Wed 07 Apr 2021 13:53:19 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:7266 Wed 07 Apr 2021 13:46:44 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:6558 Wed 07 Apr 2021 13:46:08 AEST ]]>