http://researchonline.federation.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14048 Wed 07 Apr 2021 14:02:08 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13808 Wed 07 Apr 2021 14:01:55 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11392 Wed 07 Apr 2021 13:56:42 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10534 Wed 07 Apr 2021 13:55:52 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10341 Wed 07 Apr 2021 13:55:41 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:9603 1000 young apparently healthy white men from the general population. Each Y chromosome was classified into one of 13 most common European lineages. Androgens (DHEA-S, androstenedione, total testosterone) and their metabolites (total estradiol, estrone) were measured by radioimmunoassays. Information on five dimensions of aggression (total, physical, verbal, anger and hostility) was collected using Buss and Perry questionnaire. Results: Approximately 17% men inherited haplogroup I from their fathers. Carriers of haplogroup I showed lower scores of verbal aggression than men with other haplogroups (beta = -0.72, SE = 0.29, P = 0.012) and when further compared to carriers of most common R1a lineage and other haplogroups (beta = -1.03, SE = 0.34, P = 0.003). However, these associations did not survive a correction for multiple testing. Sex steroids did not show even nominal level of association with haplogroup I. Conclusion: Our data show no overall association between haplogroup I and sex-related phenotypes in young white men. These results also suggest that the previously identified association between haplogroup I and coronary artery disease is not likely mediated by unfavourable profile of sex steroids or heightened aggression early in life. (C) 2014 Elsevier Ireland Ltd. All rights reserved.]]> Wed 07 Apr 2021 13:54:51 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:7659 Wed 07 Apr 2021 13:47:08 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:7167 Wed 07 Apr 2021 13:46:40 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5401 Wed 07 Apr 2021 13:45:02 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5378 Wed 07 Apr 2021 13:45:01 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5261 Wed 07 Apr 2021 13:44:54 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5099 Wed 07 Apr 2021 13:44:43 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:4075 Wed 07 Apr 2021 13:43:24 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:3910 2000 cardiovascular candidate loci. We found a strong association between rs13306560 polymorphism in the promoter region of MTHFR and CLCN6 and mean 24-hour diastolic blood pressure; each minor allele copy of rs13306560 was associated with 2.6 mm Hg lower mean 24-hour diastolic blood pressure (P=1.2 x 10(-8)). rs13306560 was also associated with clinic diastolic blood pressure in a combined analysis of 8129 subjects from the Genetic Regulation of Arterial Pressure of Humans in the Community Study, the CoLaus Study, and the Silesian Cardiovascular Study (P=5.4 x 10(-6)). Additional analysis of associations between variants in gene ontology-defined pathways and mean 24-hour blood pressure in the Genetic Regulation of Arterial Pressure of Humans in the Community Study showed that cell survival control signaling cascades could play a role in blood pressure regulation. There was also a significant overrepresentation of rare variants (minor allele frequency: <0.05) among polymorphisms showing at least nominal association with mean 24-hour blood pressure indicating that a considerable proportion of its heritability may be explained by uncommon alleles. Through a large-scale gene-centric analysis of ambulatory blood pressure, we identified an association of a novel variant at the MTHFR/CLNC6 locus with diastolic blood pressure and provided new insights into the genetic architecture of blood pressure.]]> Wed 07 Apr 2021 13:34:57 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:2909 Wed 07 Apr 2021 13:33:56 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:2460 Wed 07 Apr 2021 13:33:32 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:2459 Wed 07 Apr 2021 13:33:32 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:2458 Wed 07 Apr 2021 13:33:32 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:890 Wed 07 Apr 2021 13:31:52 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14703 = 18 years) recruited through opportunistic sampling were screened at sites in 92 countries during May 2019. Ideally, 3 blood pressure readings were measured for each participant, and data on lifestyle factors and comorbidities were collected. Hypertension was defined as a systolic blood pressure >= 140 mm Hg, or a diastolic blood pressure >= 90 mm Hg (mean of the second and third readings) or taking antihypertensive medication. When necessary, multiple imputation was used to estimate participants' mean blood pressure. Mixed-effects models were used to evaluate associations between blood pressure and participant characteristics. Of 1 508 130 screenees 482 273 (32.0%) had never had a blood pressure measurement before and 513 337 (34.0%) had hypertension, of whom 58.7% were aware, and 54.7% were on antihypertensive medication. Of those on medication, 57.8% were controlled to <140/90 mm Hg, and 28.9% to <130/80 mm Hg. Of all those with hypertension, 31.7% were controlled to <140/90 mm Hg, and 350 825 (23.3%) participants had untreated or inadequately treated hypertension. Of those taking antihypertensive medication, half were taking only a single drug, and 25% reported using aspirin inappropriately. This survey is the largest ever synchronized and standardized contemporary compilation of global blood pressure data. This campaign is needed as a temporary substitute for systematic blood pressure screening in many countries worldwide.]]> Tue 19 Oct 2021 16:23:32 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14223 Thu 19 May 2022 12:38:25 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14617 Thu 19 May 2022 12:02:09 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13014 Thu 07 Oct 2021 16:13:10 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5174 Fri 30 Apr 2021 15:48:56 AEST ]]>