${session.getAttribute("locale")} 5 Fibroblast growth factor binding protein 1 gene (FGFBP1) and hypertension d from pathway analysis to renal glomerulus Wed 19 Apr 2017 14:17:36 AEST ]]> Systematic genetic analysis of fibroblast growth factor signalling pathway uncovers fibroblast growth factor binding protein 1 (FGFBP1) as a novel gene of essential hypertension Wed 19 Apr 2017 14:17:32 AEST ]]> Longer leukocyte telomeres are associated with ultra-endurance exercise independent of cardiovascular risk factors Wed 08 Nov 2017 07:15:23 AEDT ]]> Urotensin-II system in genetic control of blood pressure and renal function Wed 08 Nov 2017 06:42:37 AEDT ]]> Novel insights into essential hypertension etiology revealed by genome-wide gene expression profiling of human kidneys: evidence for renin involvement via a microRNA-mediated effect on expression Wed 03 May 2017 10:01:00 AEST ]]> Whole genome survey of copy number variation in the spontaneously hypertensive rat relationship to quantitative trait loci, gene expression, and blood pressure Wed 01 May 2019 16:49:19 AEST ]]> Molecular insights into genome-wide association studies of chronic kidney disease-defining traits 100 loci of chronic kidney disease-defining traits (CKD-dt). Molecular mechanisms underlying these associations remain elusive. Using 280 kidney transcriptomes and 9958 gene expression profiles from 44 non-renal tissues we uncover gene expression partners (eGenes) for 88.9% of CKD-dt GWAS loci. Through epigenomic chromatin segmentation analysis and variant effect prediction we annotate functional consequences to 74% of these loci. Our colocalisation analysis and Mendelian randomisation in >130,000 subjects demonstrate causal effects of three eGenes (NAT8B, CASP9 and MUC1) on estimated glomerular filtration rate. We identify a common alternative splice variant in MUC1 (a gene responsible for rare Mendelian form of kidney disease) and observe increased renal expression of a specific MUC1 mRNA isoform as a plausible molecular mechanism of the GWAS association signal. These data highlight the variants and genes underpinning the associations uncovered in GWAS of CKD-dt.]]> Tue 26 Mar 2019 14:33:05 AEDT ]]> May measurement month 2018 : A pragmatic global screening campaign to raise awareness of blood pressure by the international society of hypertension Tue 22 Oct 2019 14:37:17 AEDT ]]> Body mass index is negatively associated with telomere length : A collaborative cross-sectional meta-analysis of 87 observational studies 75 y), sex, and ethnicity. Results: Each unit increase in BMI corresponded to a-3.99 bp (95% CI: -5.17, -2.81 bp) difference in TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a -7.67 bp (95% CI:-10.03,-5.31 bp) difference. Each unit increase in BMI corresponded to a -1.58 × 10-3 unit T/S ratio (0.16% decrease; 95% CI: -2.14 × 10-3, -1.01 × 10-3) difference in ageand sex-adjusted relative TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a -2.58 × 10-3 unit T/S ratio (0.26% decrease; 95% CI: -3.92 × 10-3, -1.25 × 10-3). The associations were predominantly for the white pooled population. No sex differences were observed. Conclusions: A higher BMI is associated with shorter telomeres, especially in younger individuals. The presently observed difference is not negligible. Meta-analyses of longitudinal studies evaluating change in body weight alongside change in TL arewarranted.]]> Tue 12 Feb 2019 13:15:32 AEDT ]]> May Measurement Month 2017 : An analysis of blood pressure screening results worldwide Tue 06 Nov 2018 10:17:07 AEDT ]]> Report of the 3rd annual International Society of Hypertension New Investigator Symposium. Tue 06 Feb 2018 13:16:48 AEDT ]]> Aortic augmentation index in endurance athletes : A role for cardiorespiratory fitness Tue 05 Nov 2019 11:30:44 AEDT ]]> Y chromosome haplogroup as a novel biological risk factor for coronary artery disease - The results of tracking paternal lineages in the west of Scotland primary prevention study (WOSCOPS) Thu 30 Aug 2018 16:44:56 AEST ]]> Genetic architecture of ambulatory blood pressure in the general population insights from cardiovascular gene-centric array 2000 cardiovascular candidate loci. We found a strong association between rs13306560 polymorphism in the promoter region of MTHFR and CLCN6 and mean 24-hour diastolic blood pressure; each minor allele copy of rs13306560 was associated with 2.6 mm Hg lower mean 24-hour diastolic blood pressure (P=1.2 x 10(-8)). rs13306560 was also associated with clinic diastolic blood pressure in a combined analysis of 8129 subjects from the Genetic Regulation of Arterial Pressure of Humans in the Community Study, the CoLaus Study, and the Silesian Cardiovascular Study (P=5.4 x 10(-6)). Additional analysis of associations between variants in gene ontology-defined pathways and mean 24-hour blood pressure in the Genetic Regulation of Arterial Pressure of Humans in the Community Study showed that cell survival control signaling cascades could play a role in blood pressure regulation. There was also a significant overrepresentation of rare variants (minor allele frequency: <0.05) among polymorphisms showing at least nominal association with mean 24-hour blood pressure indicating that a considerable proportion of its heritability may be explained by uncommon alleles. Through a large-scale gene-centric analysis of ambulatory blood pressure, we identified an association of a novel variant at the MTHFR/CLNC6 locus with diastolic blood pressure and provided new insights into the genetic architecture of blood pressure.]]> Thu 28 Mar 2019 16:23:09 AEDT ]]> ISH Hypertension Future Leaders Group : A network for new investigators run by new investigators Thu 28 Mar 2019 15:28:31 AEDT ]]> Pathway analysis shows association between FGFBP1 and hypertension Thu 28 Mar 2019 11:46:29 AEDT ]]> Gene expression profiling reveals renin mRNA overexpression in human hypertensive kidneys and a role for microRNAs Thu 20 Dec 2018 17:14:00 AEDT ]]> Council for high blood pressure research/InterAmerican Society of Hypertension/International Society of Hypertension: First new investigators symposium at the High Blood Pressure Research 2011 scientific sessions Mon 25 Mar 2019 11:19:51 AEDT ]]> A novel Y-specific long non-coding RNA associated with cellular lipid accumulation in HepG2 cells and Atherosclerosis-related genes Mon 20 Aug 2018 15:11:12 AEST ]]> 121 Telomere attrition is attenuated in ultra-marathon runners Mon 20 Aug 2018 11:44:38 AEST ]]> Leading the change: Second International Society of Hypertension New Investigators' Symposium Mon 20 Aug 2018 11:40:21 AEST ]]> Genetic mechanisms of vascular and renal damage Mon 20 Aug 2018 11:39:26 AEST ]]> Genetic variation within the Y chromosome is not associated with histological characteristics of the atherosclerotic carotid artery or aneurysmal wall Mon 20 Aug 2018 11:20:54 AEST ]]> FGF21 signalling pathway and metabolic traits - genetic association analysis Mon 18 Sep 2017 14:02:30 AEST ]]> Inverse associations between androgens and renal function : The Young Men Cardiovascular Association (YMCA) study Mon 16 Jan 2017 23:16:03 AEDT ]]> A common intronic variant in the gene underlying a rare monogenic form of coronary artery disease is associated with low-density lipoprotein cholesterol Mon 16 Jan 2017 18:58:38 AEDT ]]> Genetics of human essential hypertension - from single mutations to quantitative trait loci Mon 16 Jan 2017 17:56:18 AEDT ]]> Common allelic variant in the gene underlying rare monogenic form of coronary artery disease cosegregates with elevated LDL cholesterol in families with high cardiovascular risk Mon 16 Jan 2017 14:08:00 AEDT ]]> Orthologues of GSTM expressed in human kidney Mon 16 Jan 2017 11:58:26 AEDT ]]> Association between lipid profile and circulating concentrations of estrogens in young men Mon 11 Feb 2019 13:46:17 AEDT ]]> The y chromosome : A blueprint for men's health? Mon 07 May 2018 14:52:59 AEST ]]> Circulating microRNAs and hypertension - From new insights into blood pressure regulation to biomarkers of cardiovascular risk Mon 05 Nov 2018 14:06:59 AEDT ]]> Signatures of miR-181a on the renal transcriptome and blood pressure Mon 05 Nov 2018 13:44:37 AEDT ]]> Renal Mechanisms of Association between Fibroblast Growth Factor 1 and Blood Pressure Mon 05 Nov 2018 13:36:20 AEDT ]]> A multi-omics glimpse into the biology of arterial stiffness Mon 05 Nov 2018 11:29:15 AEDT ]]> Measurement of absolute copy number variation reveals association with essential hypertension Mon 05 Nov 2018 11:06:45 AEDT ]]> Coronary artery disease predisposing haplogroup I of the Y chromosome, aggression and sex steroids - Genetic association analysis 1000 young apparently healthy white men from the general population. Each Y chromosome was classified into one of 13 most common European lineages. Androgens (DHEA-S, androstenedione, total testosterone) and their metabolites (total estradiol, estrone) were measured by radioimmunoassays. Information on five dimensions of aggression (total, physical, verbal, anger and hostility) was collected using Buss and Perry questionnaire. Results: Approximately 17% men inherited haplogroup I from their fathers. Carriers of haplogroup I showed lower scores of verbal aggression than men with other haplogroups (beta = -0.72, SE = 0.29, P = 0.012) and when further compared to carriers of most common R1a lineage and other haplogroups (beta = -1.03, SE = 0.34, P = 0.003). However, these associations did not survive a correction for multiple testing. Sex steroids did not show even nominal level of association with haplogroup I. Conclusion: Our data show no overall association between haplogroup I and sex-related phenotypes in young white men. These results also suggest that the previously identified association between haplogroup I and coronary artery disease is not likely mediated by unfavourable profile of sex steroids or heightened aggression early in life. (C) 2014 Elsevier Ireland Ltd. All rights reserved.]]> Mon 05 Nov 2018 11:00:26 AEDT ]]> The pressure of finding human hypertension genes : New tools, old dilemmas Fri 26 Oct 2018 12:58:50 AEDT ]]> Strikingly low circulating CRP concentrations in ultramarathon runners independent of markers of adiposity - How low can you go? Fri 26 Jul 2019 16:36:10 AEST ]]> Cardiovascular diseases and G-protein beta 3 subunit gene (GNB3) in the era of genomewide scans Fri 26 Jul 2019 16:33:40 AEST ]]> Male-specific region of the y chromosome and cardiovascular risk phylogenetic analysis and gene expression studies Fri 26 Jul 2019 12:12:09 AEST ]]> Report of the first International Society of Hypertension (ISH) Trainee/new investigator symposium : A global hypertension initiative Fri 22 Mar 2019 14:37:27 AEDT ]]> The epithelial sodium channel y-subunit gene and blood pressure : Family based association, renal gene expression, and physiological analyses Fri 22 Mar 2019 12:59:33 AEDT ]]> Inheritance of coronary artery disease in men : An analysis of the role of the y chromosome Fri 22 Mar 2019 12:45:12 AEDT ]]> A common variant in low-density lipoprotein receptor-related protein 6 gene (LRP6) is associated with LDL-Cholesterol = 0.1) single nucleotide polymorphisms in LRP6 were genotyped in 703 individuals from 213 Polish pedigrees (Silesian Cardiovascular Study families). The family-based analysis revealed that the minor allele of rs10845493 clustered with elevated LDL-C in offspring more frequently than expected by chance (P=0.0053). The quantitative analysis restricted to subjects free of lipid-lowering treatment confirmed the association between rs10845493 and age-, sex-, and BMI-adjusted circulating levels of LDL-C in families as well as 2 additional populations - 218 unrelated subjects from Silesian Cardiovascular Study replication panel and 1138 individuals from Young Men Cardiovascular Association cohort (P=0.0268, P=0.0476, and P=0.0472, respectively). In the inverse variance weighted meta-analysis of the 3 populations each extra minor allele copy of rs10845493 was associated with 0.14 mmol/L increase in age-, sex-, and BMI-adjusted LDL-C (SE=0.05, P=0.0038). Conclusions-Common polymorphism in the gene underlying monogenic form of coronary artery disease impacts on risk of LDL-C elevation. (Arterioscler Thromb Vasc Biol. 2009;29:1316-1321.)]]> Fri 22 Feb 2019 15:34:20 AEDT ]]> Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics Fri 21 Jun 2019 12:41:06 AEST ]]> Runs of Homozygosity : Association with Coronary Artery Disease and Gene Expression in Monocytes and Macrophages Fri 17 Feb 2017 15:02:56 AEDT ]]> Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies Fri 14 Jun 2019 14:47:01 AEST ]]>