${session.getAttribute("locale")} 5 Screening of the ‘Open Scaffolds’ collection from Compounds Australia identifies a new chemical entity with anthelmintic activities against different developmental stages of the barber's pole worm and other parasitic nematodes 90%) these stages. Furthermore, this compound completely inhibited the motility of female and male adults of Brugia malayi (50–100 μM) as well as microfilariae of both B. malayi and Dirofilaria immitis (heartworm). Overall, these results show that SN00797439 acts against genetically (evolutionarily) distant parasitic nematodes i.e. H. contortus and A. ceylanicum [strongyloids] vs. B. malayi and D. immitis [filarioids] vs. T. muris [enoplid], and, thus, might offer a novel, lead-like scaffold for the development of a relatively broad-spectrum anthelmintic. Our future work will focus on assessing the activity of SN00797439 against other pathogens that cause neglected tropical diseases, optimising analogs with improved biological activities and characterising their targets. © 2017 The Authors]]> Wed 08 Nov 2017 07:06:39 AEDT ]]> Novel 1-Methyl-1H-pyrazole-5-carboxamide derivatives with potent anthelmintic activity Mon 26 Aug 2019 13:57:35 AEST ]]> Structure-activity relationship studies of tolfenpyrad reveal subnanomolar inhibitors of haemonchus contortus development Mon 26 Aug 2019 13:57:24 AEST ]]>