${session.getAttribute("locale")} 5 Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics Wed 07 Apr 2021 14:01:55 AEST ]]> Molecular insights into genome-wide association studies of chronic kidney disease-defining traits 100 loci of chronic kidney disease-defining traits (CKD-dt). Molecular mechanisms underlying these associations remain elusive. Using 280 kidney transcriptomes and 9958 gene expression profiles from 44 non-renal tissues we uncover gene expression partners (eGenes) for 88.9% of CKD-dt GWAS loci. Through epigenomic chromatin segmentation analysis and variant effect prediction we annotate functional consequences to 74% of these loci. Our colocalisation analysis and Mendelian randomisation in >130,000 subjects demonstrate causal effects of three eGenes (NAT8B, CASP9 and MUC1) on estimated glomerular filtration rate. We identify a common alternative splice variant in MUC1 (a gene responsible for rare Mendelian form of kidney disease) and observe increased renal expression of a specific MUC1 mRNA isoform as a plausible molecular mechanism of the GWAS association signal. These data highlight the variants and genes underpinning the associations uncovered in GWAS of CKD-dt.]]> Thu 19 May 2022 11:08:51 AEST ]]> Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney Mon 23 Aug 2021 11:40:02 AEST ]]> Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney Mon 12 Apr 2021 15:22:09 AEST ]]>