${session.getAttribute("locale")} 5 Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus Wed 25 Sep 2019 16:41:16 AEST ]]> Optimization of novel 1-Methyl-1H-Pyrazole-5-carboxamides leads to high potency larval development inhibitors of the Barber's pole worm Wed 24 Apr 2019 15:09:15 AEST ]]> Screening of the ‘Open Scaffolds’ collection from Compounds Australia identifies a new chemical entity with anthelmintic activities against different developmental stages of the barber's pole worm and other parasitic nematodes 90%) these stages. Furthermore, this compound completely inhibited the motility of female and male adults of Brugia malayi (50–100 μM) as well as microfilariae of both B. malayi and Dirofilaria immitis (heartworm). Overall, these results show that SN00797439 acts against genetically (evolutionarily) distant parasitic nematodes i.e. H. contortus and A. ceylanicum [strongyloids] vs. B. malayi and D. immitis [filarioids] vs. T. muris [enoplid], and, thus, might offer a novel, lead-like scaffold for the development of a relatively broad-spectrum anthelmintic. Our future work will focus on assessing the activity of SN00797439 against other pathogens that cause neglected tropical diseases, optimising analogs with improved biological activities and characterising their targets. © 2017 The Authors]]> Wed 08 Nov 2017 07:06:39 AEDT ]]> Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus Tue 21 Apr 2020 11:36:48 AEST ]]> Identification of fromiamycalin and halaminol A from Australian marine sponge extracts with anthelmintic activity against haemonchus contortus = 100 mu M). Investigation of the active fractions from the two Haliclona collections led to identification of a mixture of amino alcohol lipids, and, subsequently, a known natural product halaminol A (5). Anthelmintic profiling showed that 5 had limited potency at inhibiting larval development and motility. These data indicate that fromiamycalin, other related pentacyclic guanidine alkaloids and/or halaminols could have potential as anthelmintics following future medicinal chemistry efforts.]]> Tue 07 Jul 2020 14:41:51 AEST ]]> Synthesis and structure-activity relationship study of pyrrolidine-oxadiazoles as anthelmintics against Haemonchus contortus Tue 07 Jul 2020 10:43:48 AEST ]]> Arylpyrrole and fipronil analogues that inhibit the motility and/or development of Haemonchus contortus in vitro Thu 22 Oct 2020 14:51:32 AEDT ]]> A perspective on genomic-guided anthelmintic discovery and repurposing using Haemonchus contortus Thu 14 Dec 2017 11:19:05 AEDT ]]> Screening of a small, well-curated natural product-based library identifies two rotenoids with potent nematocidal activity against Haemonchus contortus Thu 07 Dec 2017 14:40:24 AEDT ]]> Low cost whole-organism screening of compounds for anthelmintic activity Thu 05 Dec 2019 15:07:15 AEDT ]]> A perspective on the discovery of selected compounds with anthelmintic activity against the barber's pole worm—Where to from here? Thu 02 Jul 2020 09:23:47 AEST ]]> Novel 1-Methyl-1H-pyrazole-5-carboxamide derivatives with potent anthelmintic activity Mon 26 Aug 2019 13:57:35 AEST ]]> Structure-activity relationship studies of tolfenpyrad reveal subnanomolar inhibitors of haemonchus contortus development Mon 26 Aug 2019 13:57:24 AEST ]]> Phenotypic screening of the 'Kurz-box' of chemicals identifies two compounds (BLK127 and HBK4) with anthelmintic activity in vitro against parasitic larval stages of Haemonchus contortus Mon 09 Sep 2019 14:45:56 AEST ]]> Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain Fri 24 Aug 2018 14:17:19 AEST ]]> Selected alpha-pyrones from the plants Cryptocarya novoguineensis (Lauraceae) and Piper methysticum (Piperaceae) with activity against Haemonchus contortus in vitro Fri 06 Dec 2019 14:08:17 AEDT ]]>