http://researchonline.federation.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14381 = 100 mu M). Investigation of the active fractions from the two Haliclona collections led to identification of a mixture of amino alcohol lipids, and, subsequently, a known natural product halaminol A (5). Anthelmintic profiling showed that 5 had limited potency at inhibiting larval development and motility. These data indicate that fromiamycalin, other related pentacyclic guanidine alkaloids and/or halaminols could have potential as anthelmintics following future medicinal chemistry efforts.]]> Wed 07 Apr 2021 14:02:28 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14154 Wed 07 Apr 2021 14:02:14 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13986 Wed 07 Apr 2021 14:02:05 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13687 Wed 07 Apr 2021 14:01:48 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11934 90%) these stages. Furthermore, this compound completely inhibited the motility of female and male adults of Brugia malayi (50–100 μM) as well as microfilariae of both B. malayi and Dirofilaria immitis (heartworm). Overall, these results show that SN00797439 acts against genetically (evolutionarily) distant parasitic nematodes i.e. H. contortus and A. ceylanicum [strongyloids] vs. B. malayi and D. immitis [filarioids] vs. T. muris [enoplid], and, thus, might offer a novel, lead-like scaffold for the development of a relatively broad-spectrum anthelmintic. Our future work will focus on assessing the activity of SN00797439 against other pathogens that cause neglected tropical diseases, optimising analogs with improved biological activities and characterising their targets. © 2017 The Authors]]> Wed 07 Apr 2021 13:57:13 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11768 Wed 07 Apr 2021 13:57:02 AEST ]]>