http://researchonline.federation.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13720 2-fold difference, FDR (false discovery rate) <0.5] within AAA biopsies, of which miR-155 was the most differentially expressed (11.32-fold, FDR=0.414). This finding was confirmed by qPCR with the median relative expression of miR-155 being 3.26 and 0.63 within AAA body and AAA neck biopsies respectively (P=0.031). Circulating miR-155 was also increased in AAA patients compared with controls, with a 2.67-fold up-regulation at borderline significance (FDR=0.554). Two immunologically important miR-155 target genes, CTLA4 (cytotoxic T-lymphocyte-associated protein) and SMAD2, were assessed and found to be significantly down-regulated within AAA bodies compared with AAA necks (P=0.032 and P=0.026) as determined by qPCR and Western blotting respectively. Histology demonstrated dense accumulation of T-lymphocytes within the adventitial and outer medial layers of AAA body, but not neck tissue. The results of the present study suggest that miR-155 is overexpressed in AAA with potential implications in the pathogenesis of the condition.]]> Wed 07 Apr 2021 14:01:49 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13368 Wed 07 Apr 2021 14:01:31 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13242 Wed 07 Apr 2021 14:01:24 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:12957 0.05). The penetration rate of formalin was similar to that of ethanol in both tissues however it was significantly slower than methanol (N=4, P<0.005 in the heart; P<0.001 in the liver). The mean penetration coefficients of methanol, formalin and ethanol in the heart tissue were 2.609, 1.994 and 1.801, respectively, and 3.012, 2.153 and 2.113, respectively, in the liver tissue. The penetration coefficient of methanol was significantly greater than that of ethanol or formalin in both tissues (P<0.001 for each comparison). In conclusion, methanol penetrates tissue significantly faster than ethanol and formalin.]]> Wed 07 Apr 2021 14:01:09 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:12914 7 mg/dL in men and >6 mg/dL in women. The association between sUA concentration and SBP and DBP was examined using Pearson's correlation test, multivariate linear regression, and logistic regression analysis. The prevalence of hypertension and HUA increased with age (P < .001). Hypertension was more common in participants that had HUA than in those that did not (38.95% vs 30.16%, P = .02). Higher sUA was significantly associated with higher SBP and DBP in the 41- to 50-year-old participants (SBP, β = 0.35, P < .001; DBP, β = .29, P < .001; after adjustment for age, sex, total cholesterol, estimated glomerular filtration rate, and fasting plasma glucose). HUA was also a risk factor for hypertension in this age group (odds ratio 1.425, 95% confidence interval, 1.217-1.668, P < .001). There was no association between sUA concentration and SBP and DBP in the other age groups. In this population of healthy Chinese participants, sUA concentration was positively associated with hypertension only in the 41- to 50-year-old group. Lowering uric acid in this age group may help to reduce the incidence of hypertension.]]> Wed 07 Apr 2021 14:01:07 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:12293 Wed 07 Apr 2021 14:00:34 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:12292 Wed 07 Apr 2021 14:00:34 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:12224 Wed 07 Apr 2021 14:00:31 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11954 Wed 07 Apr 2021 13:57:14 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11502 Wed 07 Apr 2021 13:56:48 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11278 Wed 07 Apr 2021 13:56:37 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14995 Wed 07 Apr 2021 13:24:57 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:12377 Tue 19 Mar 2024 11:38:09 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:18705 3.77 mmol/L, respectively. Prevalence of diabetes was higher in people with hypocholesterolemia or hypercholesterolemia than that in people with normocholesterolemia. Hypocholesterolemia was associated with an increased multivariable-adjusted risk for diabetes diagnosis (odds ratio, 1.57 95% confidence interval, 1.18–2.08), and so was hypercholesterolemia (odds ratio, 1.29 95% confidence interval, 1.10–1.51). The results remained significant after exclusion of those who took lipid-lowering drugs from the analysis. This study demonstrated that both low and high levels of LDL-C were associated with a higher risk of diabetes diagnosis. Patients with either high or low LDL-C may need to be closely monitored for the risk of diabetes .]]> Tue 12 Dec 2023 14:19:16 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:18368 Mon 18 Sep 2023 13:42:23 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:18186 Mon 11 Sep 2023 10:11:40 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:16947 Mon 11 Sep 2023 10:07:58 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17430 Mon 11 Sep 2023 10:05:29 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15089 = 10 mu M) increased absorbance in a concentration-dependent manner. The modified MTS assay produced results consistent with trypan blue exclusion and microscopy. In conclusion, a simple modification of the standard MTS assay overcame the interference of hydralazine and may be useful to avoid interference from other tested compounds.]]> Mon 10 Jan 2022 15:16:15 AEDT ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:16915 Mon 06 May 2024 10:53:09 AEST ]]> http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:19126 Mon 06 May 2024 10:26:32 AEST ]]>