http://researchonline.federation.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 Synthesis and structure-activity relationship study of pyrrolidine-oxadiazoles as anthelmintics against Haemonchus contortus http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14457 Wed 07 Apr 2021 14:02:33 AEST ]]> A perspective on the discovery of selected compounds with anthelmintic activity against the barber's pole worm—Where to from here? http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14426 Wed 07 Apr 2021 14:02:31 AEST ]]> Identification of fromiamycalin and halaminol A from Australian marine sponge extracts with anthelmintic activity against haemonchus contortus http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14381 = 100 mu M). Investigation of the active fractions from the two Haliclona collections led to identification of a mixture of amino alcohol lipids, and, subsequently, a known natural product halaminol A (5). Anthelmintic profiling showed that 5 had limited potency at inhibiting larval development and motility. These data indicate that fromiamycalin, other related pentacyclic guanidine alkaloids and/or halaminols could have potential as anthelmintics following future medicinal chemistry efforts.]]> Wed 07 Apr 2021 14:02:28 AEST ]]> Selected alpha-pyrones from the plants Cryptocarya novoguineensis (Lauraceae) and Piper methysticum (Piperaceae) with activity against Haemonchus contortus in vitro http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14154 Wed 07 Apr 2021 14:02:14 AEST ]]> Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:14034 Wed 07 Apr 2021 14:02:07 AEST ]]> Phenotypic screening of the 'Kurz-box' of chemicals identifies two compounds (BLK127 and HBK4) with anthelmintic activity in vitro against parasitic larval stages of Haemonchus contortus http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13986 Wed 07 Apr 2021 14:02:05 AEST ]]> DRfit : A Java tool for the analysis of discrete data from multi-well plate assays http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13976 Wed 07 Apr 2021 14:02:04 AEST ]]> Novel 1-Methyl-1H-pyrazole-5-carboxamide derivatives with potent anthelmintic activity http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13982 Wed 07 Apr 2021 14:02:04 AEST ]]> Structure-activity relationship studies of tolfenpyrad reveal subnanomolar inhibitors of haemonchus contortus development http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13983 Wed 07 Apr 2021 14:02:04 AEST ]]> Metabolic profiling and in vitro assessment of anthelmintic fractions of Picria fel-terrae Lour http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13736 Wed 07 Apr 2021 14:01:50 AEST ]]> Arylpyrrole and fipronil analogues that inhibit the motility and/or development of Haemonchus contortus in vitro http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13687 Wed 07 Apr 2021 14:01:48 AEST ]]> Optimization of novel 1-Methyl-1H-Pyrazole-5-carboxamides leads to high potency larval development inhibitors of the Barber's pole worm http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13694 Wed 07 Apr 2021 14:01:48 AEST ]]> Proteomic identification of galectin-11 and 14 ligands from Haemonchus contortus http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13257 Wed 07 Apr 2021 14:01:25 AEST ]]> Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13022 Wed 07 Apr 2021 14:01:13 AEST ]]> Anthelmintic activity of selected ethno-medicinal plant extracts on parasitic stages of Haemonchus contortus http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:12277 Wed 07 Apr 2021 14:00:33 AEST ]]> A perspective on genomic-guided anthelmintic discovery and repurposing using Haemonchus contortus http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:12234 Wed 07 Apr 2021 14:00:31 AEST ]]> Screening of a small, well-curated natural product-based library identifies two rotenoids with potent nematocidal activity against Haemonchus contortus http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:12184 Wed 07 Apr 2021 14:00:28 AEST ]]> Screening of the ‘Open Scaffolds’ collection from Compounds Australia identifies a new chemical entity with anthelmintic activities against different developmental stages of the barber's pole worm and other parasitic nematodes http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11934 90%) these stages. Furthermore, this compound completely inhibited the motility of female and male adults of Brugia malayi (50–100 μM) as well as microfilariae of both B. malayi and Dirofilaria immitis (heartworm). Overall, these results show that SN00797439 acts against genetically (evolutionarily) distant parasitic nematodes i.e. H. contortus and A. ceylanicum [strongyloids] vs. B. malayi and D. immitis [filarioids] vs. T. muris [enoplid], and, thus, might offer a novel, lead-like scaffold for the development of a relatively broad-spectrum anthelmintic. Our future work will focus on assessing the activity of SN00797439 against other pathogens that cause neglected tropical diseases, optimising analogs with improved biological activities and characterising their targets. © 2017 The Authors]]> Wed 07 Apr 2021 13:57:13 AEST ]]> Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11768 Wed 07 Apr 2021 13:57:02 AEST ]]> Low cost whole-organism screening of compounds for anthelmintic activity http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11288 Wed 07 Apr 2021 13:56:38 AEST ]]> Advances in the discovery and development of anthelmintics by harnessing natural product scaffolds http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15011 Thu 26 Aug 2021 12:27:56 AEST ]]> Hc-daf-2 encodes an insulin-like receptor kinase in the barber's pole worm, Haemonchus contortus, and restores partial dauer regulation http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:12881 Mon 08 Nov 2021 14:50:10 AEDT ]]> The oligomeric assembly of galectin-11 is critical for anti-parasitic activity in sheep (Ovis aries) http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:15237 Mon 06 Sep 2021 10:27:11 AEST ]]>