http://researchonline.federation.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 MicroRNA-34a and tert act as epi-drivers of cardiac telomere length and polygenic cardiac hypertrophy http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13721 Wed 07 Apr 2021 14:01:49 AEST ]]> Cardiomyocyte functional etiology in heart failure with preserved ejection fraction is distinctive - A new preclinical model http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13680 Wed 07 Apr 2021 14:01:47 AEST ]]> Involvement of human monogenic cardiomyopathy genes in experimental polygenic cardiac hypertrophy http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:13538 Wed 07 Apr 2021 14:01:40 AEST ]]> Dysregulation of c-kit expression parallels the development of spontaneous genetic cardiac hypertrophy http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:12775 Wed 07 Apr 2021 14:00:59 AEST ]]> Experimental and human evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin NGAL ) in the development of cardiac hypertrophy and heart failure http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11958 Wed 07 Apr 2021 13:57:15 AEST ]]> Genetics of blood pressure : Time to curate the collection http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:11640 Wed 07 Apr 2021 13:56:56 AEST ]]> Tripartite motif-containing 55 identified as functional candidate for spontaneous cardiac hypertrophy in the rat locus cardiac mass 22 http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10751 Wed 07 Apr 2021 13:56:06 AEST ]]> Renal Mechanisms of Association between Fibroblast Growth Factor 1 and Blood Pressure http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10534 Wed 07 Apr 2021 13:55:52 AEST ]]> Telomere dynamics during aging in polygenic left ventricular hypertrophy http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:10451 Wed 07 Apr 2021 13:55:49 AEST ]]> Measurement of absolute copy number variation reveals association with essential hypertension http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:9618 Wed 07 Apr 2021 13:54:52 AEST ]]> Up-regulation of autophagic pathways early in life might contribute to cardiac hypertrophy in a heritable polygenic model http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5379 Wed 07 Apr 2021 13:45:01 AEST ]]> Early treatment to prevent hypertension: A laudable goal http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:5368 Wed 07 Apr 2021 13:45:00 AEST ]]> Abnormal microRNA expression in cardiac hypertrophy and the regulation of the Endog gene http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:4790 1.1) were differentially expressed between HHR and NHR (n=16). We then performed an in silico analysis to predict the miRNAs that are able to bind to the 3′ untranslated region of Endog mRNA, and therefore could regulate Endog levels. We discovered that the miRNAs let-7b, miR-338 and miR-347 are predicted to bind to Endog mRNA. Functional studies are being undertaken to determine whether these miRNAs can regulate Endog mRNA levels in vitro and their role in the pathological processes leading to cardiac hypertrophy. These miRNAs could be a new target for the prevention and treatment of cardiac hypertrophy in humans]]> Wed 07 Apr 2021 13:44:20 AEST ]]> Council for high blood pressure research/InterAmerican Society of Hypertension/International Society of Hypertension: First new investigators symposium at the High Blood Pressure Research 2011 scientific sessions http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:4583 Wed 07 Apr 2021 13:44:04 AEST ]]> The epithelial sodium channel y-subunit gene and blood pressure : Family based association, renal gene expression, and physiological analyses http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:4524 Wed 07 Apr 2021 13:43:59 AEST ]]> Report of the first International Society of Hypertension (ISH) Trainee/new investigator symposium : A global hypertension initiative http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:4523 Wed 07 Apr 2021 13:43:59 AEST ]]> ISH Hypertension Future Leaders Group : A network for new investigators run by new investigators http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:4256 Wed 07 Apr 2021 13:43:42 AEST ]]> Kidney omics in hypertension: from statistical associations to biological mechanisms and clinical applications http://researchonline.federation.edu.au/vital/access/manager/Repository/vital:17466 1000 common and rare genetic variants associated with BP and/or hypertension. The kidney is not only an organ of key relevance to BP regulation and the development of hypertension, but it also acts as the tissue mediator of genetic predisposition to hypertension. The identity of kidney genes, pathways, and related mechanisms underlying the genetic associations with BP has started to emerge through integration of genomics with kidney transcriptomics, epigenomics, and other omics as well as through applications of causal inference, such as Mendelian randomization. Single-cell methods further enabled mapping of BP-associated kidney genes to cell types, and in conjunction with other omics, started to illuminate the biological mechanisms underpinning associations of BP-associated genetic variants and kidney genes. Polygenic risk scores derived from genome-wide association studies and refined on kidney omics hold the promise of enhanced diagnostic prediction, whereas kidney omics-informed drug discovery is likely to contribute new therapeutic opportunities for hypertension and hypertension-mediated kidney damage. © 2022 International Society of Nephrology]]> Thu 23 Mar 2023 11:55:08 AEDT ]]>