${session.getAttribute("locale")} 5 May measurement month 2019 the global blood pressure screening campaign of the International Society of Hypertension = 18 years) recruited through opportunistic sampling were screened at sites in 92 countries during May 2019. Ideally, 3 blood pressure readings were measured for each participant, and data on lifestyle factors and comorbidities were collected. Hypertension was defined as a systolic blood pressure >= 140 mm Hg, or a diastolic blood pressure >= 90 mm Hg (mean of the second and third readings) or taking antihypertensive medication. When necessary, multiple imputation was used to estimate participants' mean blood pressure. Mixed-effects models were used to evaluate associations between blood pressure and participant characteristics. Of 1 508 130 screenees 482 273 (32.0%) had never had a blood pressure measurement before and 513 337 (34.0%) had hypertension, of whom 58.7% were aware, and 54.7% were on antihypertensive medication. Of those on medication, 57.8% were controlled to <140/90 mm Hg, and 28.9% to <130/80 mm Hg. Of all those with hypertension, 31.7% were controlled to <140/90 mm Hg, and 350 825 (23.3%) participants had untreated or inadequately treated hypertension. Of those taking antihypertensive medication, half were taking only a single drug, and 25% reported using aspirin inappropriately. This survey is the largest ever synchronized and standardized contemporary compilation of global blood pressure data. This campaign is needed as a temporary substitute for systematic blood pressure screening in many countries worldwide.]]> Wed 07 Apr 2021 14:02:47 AEST ]]> 2020 International Society of Hypertension global hypertension practice guidelines Wed 07 Apr 2021 14:02:42 AEST ]]> A guide to the short, long and circular RNAs in hypertension and cardiovascular disease Wed 07 Apr 2021 14:02:41 AEST ]]> Highlights from the International Society of Hypertension's New Investigators Network during 2019 Wed 07 Apr 2021 14:02:31 AEST ]]> The association between selected molecular biomarkers and ambulatory blood pressure patterns in African chronic kidney disease and hypertensive patients compared with normotensive controls : protocol for a longitudinal study C and angiotensin-converting enzyme insertion and deletion polymorphisms) and biomarkers such as interleukin-6, tumor necrosis factor, soluble (s) E-selectin, homocysteine, and highly sensitive C-reactive protein have been shown to affect blood pressure variability among non-African CKD, hypertensive. and nonhypertensive CKD population. However, the contributions of the pattern, genetic, and environmental determinants of ambulatory blood pressure in African CKD have not been characterized. Understanding these interactions may help to develop interventions to prevent major cardiovascular events among people with CKD. Objective: The overarching objective of this study is to identify, document, and develop approaches to address related phenomic, genetic, and environmental determinants of ambulatory blood pressure patterns in African CKD and non-CKD hypertensive patients compared with normotensive controls. Methods: This is a longitudinal short-term follow-up study of 200 adult subjects with CKD and 200 each of age-matched hypertensives without CKD and apparently healthy controls. Demographic information, detailed clinical profile, electrocardiography, echocardiography, and 24-hr ambulatory blood pressure measurements will be obtained. Blood samples will be collected to determine albumin-creatinine ratio, fasting plasma glucose, lipid profile, electrolytes, urea and creatinine, C-reactive protein, serum homocysteine, fibroblast growth factor-23, and complete blood count, while 2 mL blood aliquot will be collected in EDTA (ethylenediaminetetraacetic acid) tubes and mixed using an electronic rolling system to prevent blood clots and subsequently used for DNA extraction and genetic analysis. Results: A total of 239 participants have been recruited so far, and it is expected that the recruitment phase will be complete in June 2020. The follow-up phase will continue with data analysis and publications of results. Conclusions: This study will help stratify Nigerian CKD patients phenotypically and genotypically in terms of their blood pressure variations with implications for targeted interventions and timing of medications to improve prognosis.]]> Wed 07 Apr 2021 14:02:24 AEST ]]> Human Y Chromosome Exerts Pleiotropic Effects on Susceptibility to Atherosclerosis Wed 07 Apr 2021 14:02:18 AEST ]]> May measurement month 2018 : A pragmatic global screening campaign to raise awareness of blood pressure by the international society of hypertension Wed 07 Apr 2021 14:02:08 AEST ]]> Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics Wed 07 Apr 2021 14:01:55 AEST ]]> Renal nerves contribute to hypertension in Schlager BPH/2J mice 0.1). The depressor response to pentolinium was greater in BPH/2J than BPN/3J, but in both cases the response in RD mice was similar to sham. Enalaprilat decreased MAP more in RD BPH/2J compared to sham (−12 vs −3 mmHg, P < 0.001) but had no effect in BPN/3J. RD reduced renal noradrenaline in both strains but more so in BPH/2J. RD reduced renin mRNA and protein, but not plasma renin in BPH/2J to levels comparable with BPN/3J mice. We conclude that renal nerves contribute to hypertension in BPH mice as RD induced a sustained fall in MAP, which was associated with a reduction of intrarenal renin expression. The lack of inhibition of the depressor effects of pentolinium and enalaprilat by RD suggests that vasoconstrictor effects of the SNS or RAS are not involved.]]> Wed 07 Apr 2021 14:01:53 AEST ]]> Leukocyte telomere length variation due to DNA extraction method Wed 07 Apr 2021 14:01:50 AEST ]]> MicroRNA-34a and tert act as epi-drivers of cardiac telomere length and polygenic cardiac hypertrophy Wed 07 Apr 2021 14:01:49 AEST ]]> Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies Wed 07 Apr 2021 14:01:48 AEST ]]> Cardiomyocyte functional etiology in heart failure with preserved ejection fraction is distinctive - A new preclinical model Wed 07 Apr 2021 14:01:47 AEST ]]> Molecular insights into genome-wide association studies of chronic kidney disease-defining traits 100 loci of chronic kidney disease-defining traits (CKD-dt). Molecular mechanisms underlying these associations remain elusive. Using 280 kidney transcriptomes and 9958 gene expression profiles from 44 non-renal tissues we uncover gene expression partners (eGenes) for 88.9% of CKD-dt GWAS loci. Through epigenomic chromatin segmentation analysis and variant effect prediction we annotate functional consequences to 74% of these loci. Our colocalisation analysis and Mendelian randomisation in >130,000 subjects demonstrate causal effects of three eGenes (NAT8B, CASP9 and MUC1) on estimated glomerular filtration rate. We identify a common alternative splice variant in MUC1 (a gene responsible for rare Mendelian form of kidney disease) and observe increased renal expression of a specific MUC1 mRNA isoform as a plausible molecular mechanism of the GWAS association signal. These data highlight the variants and genes underpinning the associations uncovered in GWAS of CKD-dt.]]> Wed 07 Apr 2021 14:01:40 AEST ]]> Involvement of human monogenic cardiomyopathy genes in experimental polygenic cardiac hypertrophy Wed 07 Apr 2021 14:01:40 AEST ]]> Body mass index is negatively associated with telomere length : A collaborative cross-sectional meta-analysis of 87 observational studies 75 y), sex, and ethnicity. Results: Each unit increase in BMI corresponded to a-3.99 bp (95% CI: -5.17, -2.81 bp) difference in TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a -7.67 bp (95% CI:-10.03,-5.31 bp) difference. Each unit increase in BMI corresponded to a -1.58 × 10-3 unit T/S ratio (0.16% decrease; 95% CI: -2.14 × 10-3, -1.01 × 10-3) difference in ageand sex-adjusted relative TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a -2.58 × 10-3 unit T/S ratio (0.26% decrease; 95% CI: -3.92 × 10-3, -1.25 × 10-3). The associations were predominantly for the white pooled population. No sex differences were observed. Conclusions: A higher BMI is associated with shorter telomeres, especially in younger individuals. The presently observed difference is not negligible. Meta-analyses of longitudinal studies evaluating change in body weight alongside change in TL arewarranted.]]> Wed 07 Apr 2021 14:01:37 AEST ]]> May Measurement Month 2017 : An analysis of blood pressure screening results worldwide Wed 07 Apr 2021 14:01:26 AEST ]]> A novel Y-specific long non-coding RNA associated with cellular lipid accumulation in HepG2 cells and Atherosclerosis-related genes Wed 07 Apr 2021 14:01:24 AEST ]]> The y chromosome : A blueprint for men's health? Wed 07 Apr 2021 14:01:12 AEST ]]> Telomeres, aging and exercise : Guilty by association? Wed 07 Apr 2021 14:01:11 AEST ]]> Dysregulation of c-kit expression parallels the development of spontaneous genetic cardiac hypertrophy Wed 07 Apr 2021 14:00:59 AEST ]]> A meta-analysis of gene expression signatures of blood pressure and hypertension Wed 07 Apr 2021 14:00:30 AEST ]]> MicroRNAs in a hypertrophic heart : From foetal life to adulthood Wed 07 Apr 2021 13:57:15 AEST ]]> Experimental and human evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin NGAL ) in the development of cardiac hypertrophy and heart failure Wed 07 Apr 2021 13:57:15 AEST ]]> Cardiac telomere length in heart development, function, and disease Wed 07 Apr 2021 13:57:02 AEST ]]> Epigenetic changes in leukocytes after 8 weeks of resistance exercise training Wed 07 Apr 2021 13:56:58 AEST ]]> Telomeres, exercise and cardiovascular disease : Finding the means to justify the ends Wed 07 Apr 2021 13:56:58 AEST ]]> Genetics of blood pressure : Time to curate the collection Wed 07 Apr 2021 13:56:56 AEST ]]> Genetic variation within the Y chromosome is not associated with histological characteristics of the atherosclerotic carotid artery or aneurysmal wall Wed 07 Apr 2021 13:56:42 AEST ]]> Telomere length maintenance and cardio-metabolic disease prevention through exercise training Wed 07 Apr 2021 13:56:26 AEST ]]> Contribution of microRNA to pathological fibrosis in cardiorenal syndrome : Impact of uremic toxins Wed 07 Apr 2021 13:56:24 AEST ]]> Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma Wed 07 Apr 2021 13:56:16 AEST ]]> Signatures of miR-181a on the renal transcriptome and blood pressure Wed 07 Apr 2021 13:56:08 AEST ]]> Aortic augmentation index in endurance athletes : A role for cardiorespiratory fitness Wed 07 Apr 2021 13:56:07 AEST ]]> Tripartite motif-containing 55 identified as functional candidate for spontaneous cardiac hypertrophy in the rat locus cardiac mass 22 Wed 07 Apr 2021 13:56:06 AEST ]]> Coronary artery disease : Why we should consider the Y chromosome Wed 07 Apr 2021 13:56:05 AEST ]]> Epigenetic modifications in essential hypertension Wed 07 Apr 2021 13:55:57 AEST ]]> Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function Wed 07 Apr 2021 13:55:53 AEST ]]> Renal Mechanisms of Association between Fibroblast Growth Factor 1 and Blood Pressure Wed 07 Apr 2021 13:55:52 AEST ]]> Increased expression of telomere-regulating genes in endurance athletes with long leukocyte telomeres 0.05). Resting heart rate emerged as an independent predictor of leukocyte telomere length and TERT and TPP1 mRNA expression in stepwise regression models. To gauge whether volume of exercise was associated with leukocyte telomere length, we divided subjects into running and cycling tertiles (distance covered per week) and found individuals in the middle and highest tertiles had longer telomeres than individuals in the lowest tertile. These data emphasize the importance of cardiorespiratory fitness and exercise training in the prevention of biological aging. They also support the concept that moderate amounts of exercise training protects against biological aging, while higher amounts may not elicit additional benefits.]]> Wed 07 Apr 2021 13:55:51 AEST ]]> Genome-wide sperm DNA methylation changes after 3 months of exercise training in humans Wed 07 Apr 2021 13:55:51 AEST ]]> Circulating microRNAs and hypertension - From new insights into blood pressure regulation to biomarkers of cardiovascular risk Wed 07 Apr 2021 13:55:50 AEST ]]> Telomere dynamics during aging in polygenic left ventricular hypertrophy Wed 07 Apr 2021 13:55:49 AEST ]]> MicroRNAs mediate the cardioprotective effect of angiotensin-converting enzyme inhibition in acute kidney injury Wed 07 Apr 2021 13:55:42 AEST ]]> MicroRNAs in essential hypertension and blood pressure regulation Wed 07 Apr 2021 13:55:42 AEST ]]> A multi-omics glimpse into the biology of arterial stiffness Wed 07 Apr 2021 13:55:41 AEST ]]> Runs of Homozygosity : Association with Coronary Artery Disease and Gene Expression in Monocytes and Macrophages Wed 07 Apr 2021 13:55:29 AEST ]]> The emerging role of non-coding RNA in essential hypertension and blood pressure regulation Wed 07 Apr 2021 13:55:26 AEST ]]> Measurement of absolute copy number variation reveals association with essential hypertension Wed 07 Apr 2021 13:54:52 AEST ]]> Coronary artery disease predisposing haplogroup I of the Y chromosome, aggression and sex steroids - Genetic association analysis 1000 young apparently healthy white men from the general population. Each Y chromosome was classified into one of 13 most common European lineages. Androgens (DHEA-S, androstenedione, total testosterone) and their metabolites (total estradiol, estrone) were measured by radioimmunoassays. Information on five dimensions of aggression (total, physical, verbal, anger and hostility) was collected using Buss and Perry questionnaire. Results: Approximately 17% men inherited haplogroup I from their fathers. Carriers of haplogroup I showed lower scores of verbal aggression than men with other haplogroups (beta = -0.72, SE = 0.29, P = 0.012) and when further compared to carriers of most common R1a lineage and other haplogroups (beta = -1.03, SE = 0.34, P = 0.003). However, these associations did not survive a correction for multiple testing. Sex steroids did not show even nominal level of association with haplogroup I. Conclusion: Our data show no overall association between haplogroup I and sex-related phenotypes in young white men. These results also suggest that the previously identified association between haplogroup I and coronary artery disease is not likely mediated by unfavourable profile of sex steroids or heightened aggression early in life. (C) 2014 Elsevier Ireland Ltd. All rights reserved.]]> Wed 07 Apr 2021 13:54:51 AEST ]]> Report of the 3rd annual International Society of Hypertension New Investigator Symposium. Wed 07 Apr 2021 13:47:08 AEST ]]> Changes in the leukocyte methylome and its effect on cardiovascular-related genes after exercise Wed 07 Apr 2021 13:47:06 AEST ]]> 121 Telomere attrition is attenuated in ultra-marathon runners Wed 07 Apr 2021 13:46:40 AEST ]]> The acute effects of intense cardiorespiratory exercise on human telomerase reverse transcriptase and sirtuin 6 expression in white blood cells Wed 07 Apr 2021 13:46:39 AEST ]]> Consumption of a low glycaemic index diet in late life extends lifespan of Nalb/c mice with differential effects on DNA damage Wed 07 Apr 2021 13:46:28 AEST ]]> A novel interaction between sympathetic overactivity and aberrant regulation of renin by miR-181a in BPH/2J genetically hypertensive mice Wed 07 Apr 2021 13:46:28 AEST ]]> Small molecules, big effects: The role of microRNAs in regulation of cardiomyocyte death Wed 07 Apr 2021 13:46:03 AEST ]]> Acute exercise leads to regulation of Telomere-Associated genes and MicroRNA expression in immune Cells Wed 07 Apr 2021 13:45:22 AEST ]]> Exercise : Putting action into our epigenome Wed 07 Apr 2021 13:45:18 AEST ]]> Urotensin-II system in genetic control of blood pressure and renal function Wed 07 Apr 2021 13:45:18 AEST ]]> Leading the change: Second International Society of Hypertension New Investigators' Symposium Wed 07 Apr 2021 13:45:02 AEST ]]> Up-regulation of autophagic pathways early in life might contribute to cardiac hypertrophy in a heritable polygenic model Wed 07 Apr 2021 13:45:01 AEST ]]> Novel insights into essential hypertension etiology revealed by genome-wide gene expression profiling of human kidneys: evidence for renin involvement via a microRNA-mediated effect on expression Wed 07 Apr 2021 13:45:01 AEST ]]> Early treatment to prevent hypertension: A laudable goal Wed 07 Apr 2021 13:45:00 AEST ]]> Genetic mechanisms of vascular and renal damage Wed 07 Apr 2021 13:44:54 AEST ]]> Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study Wed 07 Apr 2021 13:44:53 AEST ]]> Longer leukocyte telomeres are associated with ultra-endurance exercise independent of cardiovascular risk factors Wed 07 Apr 2021 13:44:45 AEST ]]> Male-specific region of the y chromosome and cardiovascular risk phylogenetic analysis and gene expression studies Wed 07 Apr 2021 13:44:43 AEST ]]> Salt Loading in Canola Oil Fed SHRSP Rats Induces Endothelial Dysfunction Wed 07 Apr 2021 13:44:42 AEST ]]> RNA sequencing data from the human kidney Wed 07 Apr 2021 13:44:32 AEST ]]> Abnormal microRNA expression in cardiac hypertrophy and the regulation of the Endog gene 1.1) were differentially expressed between HHR and NHR (n=16). We then performed an in silico analysis to predict the miRNAs that are able to bind to the 3′ untranslated region of Endog mRNA, and therefore could regulate Endog levels. We discovered that the miRNAs let-7b, miR-338 and miR-347 are predicted to bind to Endog mRNA. Functional studies are being undertaken to determine whether these miRNAs can regulate Endog mRNA levels in vitro and their role in the pathological processes leading to cardiac hypertrophy. These miRNAs could be a new target for the prevention and treatment of cardiac hypertrophy in humans]]> Wed 07 Apr 2021 13:44:20 AEST ]]> Council for high blood pressure research/InterAmerican Society of Hypertension/International Society of Hypertension: First new investigators symposium at the High Blood Pressure Research 2011 scientific sessions Wed 07 Apr 2021 13:44:04 AEST ]]> Gene expression profiling reveals renin mRNA overexpression in human hypertensive kidneys and a role for microRNAs Wed 07 Apr 2021 13:44:02 AEST ]]> Inheritance of coronary artery disease in men : An analysis of the role of the y chromosome Wed 07 Apr 2021 13:43:59 AEST ]]> The epithelial sodium channel y-subunit gene and blood pressure : Family based association, renal gene expression, and physiological analyses Wed 07 Apr 2021 13:43:59 AEST ]]> Report of the first International Society of Hypertension (ISH) Trainee/new investigator symposium : A global hypertension initiative Wed 07 Apr 2021 13:43:59 AEST ]]> A MicroRNA Guide for Clinicians and Basic Scientists : Background and Experimental Techniques Wed 07 Apr 2021 13:43:59 AEST ]]> Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk Wed 07 Apr 2021 13:43:42 AEST ]]> ISH Hypertension Future Leaders Group : A network for new investigators run by new investigators Wed 07 Apr 2021 13:43:42 AEST ]]> Pathway analysis shows association between FGFBP1 and hypertension Wed 07 Apr 2021 13:43:24 AEST ]]> Genetic architecture of ambulatory blood pressure in the general population insights from cardiovascular gene-centric array 2000 cardiovascular candidate loci. We found a strong association between rs13306560 polymorphism in the promoter region of MTHFR and CLCN6 and mean 24-hour diastolic blood pressure; each minor allele copy of rs13306560 was associated with 2.6 mm Hg lower mean 24-hour diastolic blood pressure (P=1.2 x 10(-8)). rs13306560 was also associated with clinic diastolic blood pressure in a combined analysis of 8129 subjects from the Genetic Regulation of Arterial Pressure of Humans in the Community Study, the CoLaus Study, and the Silesian Cardiovascular Study (P=5.4 x 10(-6)). Additional analysis of associations between variants in gene ontology-defined pathways and mean 24-hour blood pressure in the Genetic Regulation of Arterial Pressure of Humans in the Community Study showed that cell survival control signaling cascades could play a role in blood pressure regulation. There was also a significant overrepresentation of rare variants (minor allele frequency: <0.05) among polymorphisms showing at least nominal association with mean 24-hour blood pressure indicating that a considerable proportion of its heritability may be explained by uncommon alleles. Through a large-scale gene-centric analysis of ambulatory blood pressure, we identified an association of a novel variant at the MTHFR/CLNC6 locus with diastolic blood pressure and provided new insights into the genetic architecture of blood pressure.]]> Wed 07 Apr 2021 13:34:57 AEST ]]> FGF21 signalling pathway and metabolic traits - genetic association analysis Wed 07 Apr 2021 13:34:55 AEST ]]> Fibroblast growth factor binding protein 1 gene (FGFBP1) and hypertension d from pathway analysis to renal glomerulus Wed 07 Apr 2021 13:34:42 AEST ]]> Whole genome survey of copy number variation in the spontaneously hypertensive rat relationship to quantitative trait loci, gene expression, and blood pressure Wed 07 Apr 2021 13:33:56 AEST ]]> Genetics of human essential hypertension - from single mutations to quantitative trait loci Wed 07 Apr 2021 13:33:54 AEST ]]> Orthologues of GSTM expressed in human kidney Wed 07 Apr 2021 13:33:32 AEST ]]> Strikingly low circulating CRP concentrations in ultramarathon runners independent of markers of adiposity - How low can you go? Wed 07 Apr 2021 13:33:32 AEST ]]> Cardiovascular diseases and G-protein beta 3 subunit gene (GNB3) in the era of genomewide scans Wed 07 Apr 2021 13:33:32 AEST ]]> Systematic genetic analysis of fibroblast growth factor signalling pathway uncovers fibroblast growth factor binding protein 1 (FGFBP1) as a novel gene of essential hypertension Wed 07 Apr 2021 13:33:12 AEST ]]> A common variant in low-density lipoprotein receptor-related protein 6 gene (LRP6) is associated with LDL-Cholesterol = 0.1) single nucleotide polymorphisms in LRP6 were genotyped in 703 individuals from 213 Polish pedigrees (Silesian Cardiovascular Study families). The family-based analysis revealed that the minor allele of rs10845493 clustered with elevated LDL-C in offspring more frequently than expected by chance (P=0.0053). The quantitative analysis restricted to subjects free of lipid-lowering treatment confirmed the association between rs10845493 and age-, sex-, and BMI-adjusted circulating levels of LDL-C in families as well as 2 additional populations - 218 unrelated subjects from Silesian Cardiovascular Study replication panel and 1138 individuals from Young Men Cardiovascular Association cohort (P=0.0268, P=0.0476, and P=0.0472, respectively). In the inverse variance weighted meta-analysis of the 3 populations each extra minor allele copy of rs10845493 was associated with 0.14 mmol/L increase in age-, sex-, and BMI-adjusted LDL-C (SE=0.05, P=0.0038). Conclusions-Common polymorphism in the gene underlying monogenic form of coronary artery disease impacts on risk of LDL-C elevation. (Arterioscler Thromb Vasc Biol. 2009;29:1316-1321.)]]> Wed 07 Apr 2021 13:33:12 AEST ]]> Y chromosome haplogroup as a novel biological risk factor for coronary artery disease - The results of tracking paternal lineages in the west of Scotland primary prevention study (WOSCOPS) Wed 07 Apr 2021 13:33:11 AEST ]]> A common intronic variant in the gene underlying a rare monogenic form of coronary artery disease is associated with low-density lipoprotein cholesterol Wed 07 Apr 2021 13:33:10 AEST ]]> Whole genome survey of copy number variation between the spontaneously hypersensitive rat and the wistar-kyoto rat Wed 07 Apr 2021 13:33:09 AEST ]]> The pressure of finding human hypertension genes : New tools, old dilemmas Wed 07 Apr 2021 13:32:50 AEST ]]> An improved 3-(4,5-dmethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl )-2H-tetrazolium proliferation assay to overcome the interference of hydralazine = 10 mu M) increased absorbance in a concentration-dependent manner. The modified MTS assay produced results consistent with trypan blue exclusion and microscopy. In conclusion, a simple modification of the standard MTS assay overcame the interference of hydralazine and may be useful to avoid interference from other tested compounds.]]> Tue 01 Jun 2021 13:05:11 AEST ]]> DNA copy number variations – Do these big mutations have a big effect on cardiovascular risk? Thu 20 May 2021 10:20:30 AEST ]]> Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency ≤ 0.01) variant BP associations (P < 5 × 10−8), of which 32 were in new BP-associated loci and 55 were independent BP-associated single-nucleotide variants within known BP-associated regions. Average effects of rare variants (44% coding) were ~8 times larger than common variant effects and indicate potential candidate causal genes at new and known loci (for example, GATA5 and PLCB3). BP-associated variants (including rare and common) were enriched in regions of active chromatin in fetal tissues, potentially linking fetal development with BP regulation in later life. Multivariable Mendelian randomization suggested possible inverse effects of elevated systolic and diastolic BP on large artery stroke. Our study demonstrates the utility of rare-variant analyses for identifying candidate genes and the results highlight potential therapeutic targets. © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. There are 286 authors of this articles not all are listed in this record.]]> Mon 31 May 2021 13:34:32 AEST ]]> Plasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting Mon 17 May 2021 13:30:30 AEST ]]> Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney Mon 12 Apr 2021 15:22:09 AEST ]]> Association between lipid profile and circulating concentrations of estrogens in young men Fri 30 Apr 2021 15:48:56 AEST ]]>