- Title
- High CD26 and low CD94 expression identifies an IL-23 responsive Vδ2+ T Cell subset with a MAIT cell-like transcriptional profile
- Creator
- Wragg, Kathleen; Tan, Hyon; Kristensen, Anne; Nguyen-Robertson, Catriona; Kelleher, Anthony; Parsons, Matthew; Wheatley, Adam; Berzins, Stuart; Pellicci, Daniel; Kent, Stephen; Juno, Jennifer
- Date
- 2020
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/173359
- Identifier
- vital:14683
- Identifier
-
https://doi.org/10.1016/j.celrep.2020.107773
- Identifier
- ISBN:2211-1247 (ISSN)
- Abstract
- Vδ2+ T cells play a critical role in immunity to micro-organisms and cancer but exhibit substantial heterogeneity in humans. Here, we demonstrate that CD26 and CD94 define transcriptionally, phenotypically, and functionally distinct Vδ2+ T cell subsets. Despite distinct antigen specificities, CD26hiCD94lo Vδ2+ cells exhibit substantial similarities to CD26hi mucosal-associated invariant T (MAIT) cells, although CD26− Vδ2+ cells exhibit cytotoxic, effector-like profiles. At birth, the Vδ2+Vγ9+ population is dominated by CD26hiCD94lo cells; during adolescence and adulthood, Vδ2+ cells acquire CD94/NKG2A expression and the relative frequency of the CD26hiCD94lo subset declines. Critically, exposure of the CD26hiCD94lo subset to phosphoantigen in the context of interleukin-23 (IL-23) and CD26 engagement drives the acquisition of a cytotoxic program and concurrent loss of the MAIT cell-like phenotype. The ability to modulate the cytotoxic potential of CD26hiCD94lo Vδ2+ cells, combined with their adenosine-binding capacity, may make them ideal targets for immunotherapeutic expansion and adoptive transfer. Wragg et al. identify a population of human gd T cells with striking similarities to MAIT cells. These cells dominate the cord blood Vd2 population and upregulate an effector-like program upon antigen and IL-23 stimulation, providing a potential mechanism by which cytotoxic Vd2 cells may accumulate during adolescence and adulthood. © 2020; National Health and Medical Research Council, NHMRC
- Publisher
- Elsevier B.V.
- Relation
- Cell Reports Vol. 31, no. 11 (2020), p.
- Rights
- https://creativecommons.org/licenses/by/4.0/
- Rights
- Crown Copyright @ 2020
- Rights
- Open Access
- Rights
- This metadata is freely available under a CCO license
- Subject
- 0601 Biochemistry and Cell Biology; 1103 Clinical Sciences; 1109 Neurosciences; CD26; CD94; Gamma delta; IL-23; MAIT; Vd2; Vg9
- Full Text
- Reviewed
- Funder
- National Health and Medical Research Council, NHMRC
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