- Title
- A guide to the short, long and circular RNAs in hypertension and cardiovascular disease
- Creator
- Prestes, Priscilla; Maier, Michelle; Woods, Bradley; Charchar, Fadi
- Date
- 2020
- Type
- Text; Journal article; Review
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/172955
- Identifier
- vital:14597
- Identifier
-
https://doi.org/10.3390/ijms21103666
- Identifier
- ISBN:1661-6596 (ISSN)
- Abstract
- Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in adults in developed countries. CVD encompasses many diseased states, including hypertension, coronary artery disease and atherosclerosis. Studies in animal models and human studies have elucidated the contribution of many genetic factors, including non-coding RNAs. Non-coding RNAs are RNAs not translated into protein, involved in gene expression regulation post-transcriptionally and implicated in CVD. Of these, circular RNAs (circRNAs) and microRNAs are relevant. CircRNAs are created by the back-splicing of pre-messenger RNA and have been underexplored as contributors to CVD. These circRNAs may also act as biomarkers of human disease, as they can be extracted from whole blood, plasma, saliva and seminal fluid. CircRNAs have recently been implicated in various disease processes, including hypertension and other cardiovascular disease. This review article will explore the promising and emerging roles of circRNAs as potential biomarkers and therapeutic targets in CVD, in particular hypertension. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
- Publisher
- MDPI AG
- Relation
- International Journal of Molecular Sciences Vol. 21, no. 10 (2020)
- Rights
- http://creativecommons.org/licenses/by/4.0/
- Rights
- Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
- Rights
- Open Access
- Rights
- This metadata is freely available under a CCO license
- Subject
- 0399 Other Chemical Sciences; 0604 Genetics; 0699 Other Biological Sciences; Atherosclerosis; Cardiovascular disease; Circular RNA; Coronary artery disease; Heart disease; Hypertension; Long non-coding RNA; MicroRNA
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