Male-specific region of the y chromosome and cardiovascular risk phylogenetic analysis and gene expression studies
- Bloomer, Lisa, Nelson, Christopher, Eales, James, Denniff, Matthew, Christofidou, Paraskevi, Debiec, Radoslaw, Moore, Jasbir, Consortium, Cardiogenics, Zukowska-Szczechowska, Ewa, Goodall, Alison, Thompson, John, Samani, Nilesh, Charchar, Fadi, Tomaszewski, Maciej
- Authors: Bloomer, Lisa , Nelson, Christopher , Eales, James , Denniff, Matthew , Christofidou, Paraskevi , Debiec, Radoslaw , Moore, Jasbir , Consortium, Cardiogenics , Zukowska-Szczechowska, Ewa , Goodall, Alison , Thompson, John , Samani, Nilesh , Charchar, Fadi , Tomaszewski, Maciej
- Date: 2013
- Type: Text , Journal article
- Relation: Arteriosclerosis, Thrombosis, and Vascular Biology Vol. 33, no. 7 (2013), p. 1722-1727
- Relation: http://purl.org/au-research/grants/nhmrc/1009490
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- Description: Objective-Haplogroup I of male-specific region of the human Y chromosome is associated with 50% increased risk of coronary artery disease. It is not clear to what extent conventional cardiovascular risk factors and genes of the malespecific region may explain this association. Approach and Results-A total of 1988 biologically unrelated men from 4 white European populations were genotyped using 11 Y chromosome single nucleotide polymorphisms and classified into 13 most common European haplogroups. Approximately 75% to 93% of the haplotypic variation of the Y chromosome in all cohorts was attributable to I, R1a, and R1b1b2 lineages. None of traditional cardiovascular risk factors, including body mass index, blood pressures, lipids, glucose, C-reactive protein, creatinine, and insulin resistance, was associated with haplogroup I of the Y chromosome in the joint inverse variance meta-analysis. Fourteen of 15 ubiquitous single-copy genes of the male-specific region were expressed in human macrophages. When compared with men with other haplogroups, carriers of haplogroup I had 0.61- and 0.64-fold lower expression of ubiquitously transcribed tetratricopeptide repeat, Y-linked gene (UTY) and protein kinase, Y-linked, pseudogene (PRKY) in macrophages (P=0.0001 and P=0.002, respectively). Conclusions-Coronary artery disease predisposing haplogroup I of the Y chromosome is associated with downregulation of UTY and PRKY genes in macrophages but not with conventional cardiovascular risk factors. © 2013 American Heart Association, Inc.
- Description: 2003011132
- Authors: Bloomer, Lisa , Nelson, Christopher , Eales, James , Denniff, Matthew , Christofidou, Paraskevi , Debiec, Radoslaw , Moore, Jasbir , Consortium, Cardiogenics , Zukowska-Szczechowska, Ewa , Goodall, Alison , Thompson, John , Samani, Nilesh , Charchar, Fadi , Tomaszewski, Maciej
- Date: 2013
- Type: Text , Journal article
- Relation: Arteriosclerosis, Thrombosis, and Vascular Biology Vol. 33, no. 7 (2013), p. 1722-1727
- Relation: http://purl.org/au-research/grants/nhmrc/1009490
- Full Text:
- Reviewed:
- Description: Objective-Haplogroup I of male-specific region of the human Y chromosome is associated with 50% increased risk of coronary artery disease. It is not clear to what extent conventional cardiovascular risk factors and genes of the malespecific region may explain this association. Approach and Results-A total of 1988 biologically unrelated men from 4 white European populations were genotyped using 11 Y chromosome single nucleotide polymorphisms and classified into 13 most common European haplogroups. Approximately 75% to 93% of the haplotypic variation of the Y chromosome in all cohorts was attributable to I, R1a, and R1b1b2 lineages. None of traditional cardiovascular risk factors, including body mass index, blood pressures, lipids, glucose, C-reactive protein, creatinine, and insulin resistance, was associated with haplogroup I of the Y chromosome in the joint inverse variance meta-analysis. Fourteen of 15 ubiquitous single-copy genes of the male-specific region were expressed in human macrophages. When compared with men with other haplogroups, carriers of haplogroup I had 0.61- and 0.64-fold lower expression of ubiquitously transcribed tetratricopeptide repeat, Y-linked gene (UTY) and protein kinase, Y-linked, pseudogene (PRKY) in macrophages (P=0.0001 and P=0.002, respectively). Conclusions-Coronary artery disease predisposing haplogroup I of the Y chromosome is associated with downregulation of UTY and PRKY genes in macrophages but not with conventional cardiovascular risk factors. © 2013 American Heart Association, Inc.
- Description: 2003011132
- Authors: Wang, Yutang , Fang, Yan
- Date: 2022
- Type: Text , Journal article
- Relation: Diabetes epidemiology and management Vol. 6, no. (2022), p. 100045
- Full Text: false
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- Description: •Postabsorptive HOMA-IR was associated with CVD mortality.•Postabsorptive HOMA-IR was associated with diabetes mortality.•Postabsorptive HOMA-IR was associated with all-cause mortality. This study aimed to investigate associations of postabsorptive homeostasis model assessment for insulin resistance (HOMA-IR) with mortality. This cohort study included 13,927 US adults, among which 5,552 and 8,375 were examined at the postabsorptive and fasting state, respectively. Mortality outcomes were ascertained by linkage to the National Death Index records. The medians of postabsorptive and fasting HOMA-IR were 2.0 and 2.2, respectively. This cohort was followed up for 271,652 person-years with a mean follow-up of 19.5 years. During the follow-up, 5,235, 1,580, and 493 deaths from all causes, cardiovascular disease (CVD), and diabetes were recorded, respectively. A 1-natural-log-unit increase in postabsorptive HOMA-IR was associated with higher multivariate-adjusted risks for CVD mortality (HR, 1.30 95% CI, 1.12–1.50) and all-cause mortality (HR, 1.35 95% CI, 1.25–1.47). Similarly, a 1-natural-log-unit increase in fasting HOMA-IR was associated with higher multivariate-adjusted risks for CVD mortality (HR, 1.30 95% CI, 1.14–1.48) and all-cause mortality (HR, 1.27 95% CI, 1.19–1.36). Postabsorptive homeostasis model assessment for insulin resistance is a reliable biomarker for CVD mortality and all-cause mortality.
High-intensity interval training is safe, feasible and efficacious in nonalcoholic steatohepatitis : a randomized controlled trial
- Keating, Shelley, Croci, Ilaria, Wallen, Matthew, Cox, Emily, Thuzar, Moe, Pham, Uyen, Mielke, Gregore, Coombes, Jeff, Macdonald, Graeme, Hickman, Ingrid
- Authors: Keating, Shelley , Croci, Ilaria , Wallen, Matthew , Cox, Emily , Thuzar, Moe , Pham, Uyen , Mielke, Gregore , Coombes, Jeff , Macdonald, Graeme , Hickman, Ingrid
- Date: 2023
- Type: Text , Journal article
- Relation: Digestive Diseases and Sciences Vol. 68, no. 5 (2023), p. 2123-2139
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- Description: Background: High-Intensity Interval Training (HIIT) involves bursts of high-intensity exercise interspersed with lower-intensity exercise recovery. HIIT may benefit cardiometabolic health in people with nonalcoholic steatohepatitis (NASH). Aims: We aimed to examine the safety, feasibility, and efficacy of 12-weeks of supervised HIIT compared with a sham-exercise control (CON) for improving aerobic fitness and peripheral insulin sensitivity in biopsy-proven NASH. Methods: Participants based in the community [(n = 14, 56 ± 10 years, BMI 39.2 ± 6.7 kg/m2, 64% male), NAFLD Activity Score 5 (range 3–7)] were randomized to 12-weeks of supervised HIIT (n = 8, 4 × 4 min at 85–95% maximal heart rate, interspersed with 3 min active recovery; 3 days/week) or CON (n = 6, stretching; 3 days/week). Safety (adverse events) and feasibility determined as
- Authors: Keating, Shelley , Croci, Ilaria , Wallen, Matthew , Cox, Emily , Thuzar, Moe , Pham, Uyen , Mielke, Gregore , Coombes, Jeff , Macdonald, Graeme , Hickman, Ingrid
- Date: 2023
- Type: Text , Journal article
- Relation: Digestive Diseases and Sciences Vol. 68, no. 5 (2023), p. 2123-2139
- Full Text:
- Reviewed:
- Description: Background: High-Intensity Interval Training (HIIT) involves bursts of high-intensity exercise interspersed with lower-intensity exercise recovery. HIIT may benefit cardiometabolic health in people with nonalcoholic steatohepatitis (NASH). Aims: We aimed to examine the safety, feasibility, and efficacy of 12-weeks of supervised HIIT compared with a sham-exercise control (CON) for improving aerobic fitness and peripheral insulin sensitivity in biopsy-proven NASH. Methods: Participants based in the community [(n = 14, 56 ± 10 years, BMI 39.2 ± 6.7 kg/m2, 64% male), NAFLD Activity Score 5 (range 3–7)] were randomized to 12-weeks of supervised HIIT (n = 8, 4 × 4 min at 85–95% maximal heart rate, interspersed with 3 min active recovery; 3 days/week) or CON (n = 6, stretching; 3 days/week). Safety (adverse events) and feasibility determined as
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