- Title
- Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
- Creator
- Chambers, John; Zhang, Weihua; Sehmi, Joban; Li, Xinzhong; Wass, Mark N; van der Harst, Pim; Holm, Hilma; Sanna, Serena; Kavousi, Maryam; Charchar, Fadi
- Date
- 2011
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/103411
- Identifier
- vital:10894
- Identifier
-
https://doi.org/10.1038/ng.970
- Identifier
- ISSN:1061-4036
- Abstract
- Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10−8 to P = 10−190). We used functional genomic approaches including metabonomic profiling and gene expression analyses to identify probable candidate genes at these regions. We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827). Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function. 137 authors
- Relation
- Nature genetics Vol. 43, no. 11 (2011), p. 1131-1138
- Rights
- Copyright Nature Genetics
- Rights
- This metadata is freely available under a CCO license
- Subject
- Enzymes; Genetic variation; Liver diseases; Metabolism; 11 Medical and Health Sciences; 06 Biological Sciences
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