Description:
Prion diseases are invariabiably fatal and highly infectious neurodegenerative diseases that affect humans and animals. Rabbits are the only mammalian species reported to be resistant to infection from prion diseases isolated from other species (Vorber et.al., 2003). Fortunately, the NMR structure of rabbit prion (124-228) (PDB entry 2FJ3), the NMR structure of rabbit prion protein mutation s173N (PDB entry 2JOH) and the NMR structure of rabbit prion protein I214V [PDB entry 2JOM} were released recently. This paper studies these NMR structures by molecular dyanmaics simulations. Simulation results confirm the structural ability of wild-type rabbit prion, and show that the salt bridge between D177 and R163 greatly contributes to the structural stability of rabbity prion. Crown Copyright Published by Elsevier.
Anxiety online-A virtual clinic: Preliminary outcomes following completion of five fully automated treatment programs for anxiety disorders and symptoms
Description:
To ensure customer satisfaction and greater market acceptance, voice over Wi-Fi networks must ensure voice quality under various network parameters, configurations and traffic conditions, and other practical effects, e.g., channel noise, and capturing effects. An accurate voice capacity estimation model considering these factors can greatly assist network designers. In the current work, we propose an analytical model to estimate voice over Internet Protocol (VoIP) capacity over Wi-Fi networks addressing these issues. We employ widely used ITU-T E-model to assess voice quality and VoIP call capacity is presented in the form of an optimization problem with voice quality requirement as a constraint. In particular, we analyze delay and loss in channel access and queue, and their impacts on voice quality. The proposed capacity model is first developed for a single hop wireless local area network (WLAN) and then extended for multihop scenarios. To model real network scenario closely, we also consider channel noise and capture effect, and analyze the impacts of transmission range, interference range, and WLAN radius. In absence of any existing call capacity model that considers all the above factors concomitantly, our proposed model will be extremely useful to network designers and voice capacity planners.
Description:
WSNs generate huge amount of data in the form of streams and mining useful knowledge from these streams is a challenging task. Existing works generate sensor association rules using occurrence frequency of patterns with binary frequency (either absent or present) or support of a pattern as a criterion. However, considering the binary frequency or support of a pattern may not be a sufficient indicator for finding meaningful patterns from WSN data because it only reflects the number of epochs in the sensor data which contain that pattern. The share measure of sensorsets could discover useful knowledge about numerical values associated with sensor in a sensor database. Therefore, in this paper, we propose a new type of behavioral pattern called share-frequent sensor patterns by considering the non-binary frequency values of sensors in epochs. To discover share-frequent sensor patterns from sensor dataset, we propose a novel parallel technique. In this technique, we develop a novel tree structure, called parallel share-frequent sensor pattern tree (PShrFSP-tree) that is constructed at each local node independently, by capturing the database contents to generate the candidate patterns using a pattern growth technique with a single scan and then merges the locally generated candidate patterns at the final stage to generate global share-frequent sensor patterns. Comprehensive experimental results show that our proposed model is very efficient for mining share-frequent patterns from WSN data in terms of time and scalability.
Description:
WSNs generate huge amount of data in the form of streams and mining useful knowledge from these streams is a challenging task. Existing works generate sensor association rules using occurrence frequency of patterns with binary frequency (either absent or present) or support of a pattern as a criterion. However, considering the binary frequency or support of a pattern may not be a sufficient indicator for finding meaningful patterns from WSN data because it only reflects the number of epochs in the sensor data which contain that pattern. The share measure of sensorsets could discover useful knowledge about numerical values associated with sensor in a sensor database. Therefore, in this paper, we propose a new type of behavioral pattern called share-frequent sensor patterns by considering the non-binary frequency values of sensors in epochs. To discover share-frequent sensor patterns from sensor dataset, we propose a novel parallel technique. In this technique, we develop a novel tree structure, called parallel share-frequent sensor pattern tree (PShrFSP-tree) that is constructed at each local node independently, by capturing the database contents to generate the candidate patterns using a pattern growth technique with a single scan and then merges the locally generated candidate patterns at the final stage to generate global share-frequent sensor patterns. Comprehensive experimental results show that our proposed model is very efficient for mining share-frequent patterns from WSN data in terms of time and scalability.
Description:
n this paper we propose a motion based approach for synthesizing dynamic textures. Dynamic textures are natural phenomenon characterized by their distinctive motion patterns. Synthesis of these textures is thus considered as the regeneration of a motion pattern that has identical motion distribution of a source texture. In this paper we propose a synthesis technique where new textures are generated by computing their movement pattern from a known motion distribution followed by the generation of image frames. Experimental results demonstrate the ability of the proposed technique by producing visually promising dynamic textures.
Description:
This paper explores the pedagogical and social potential of emerging technologies, in particular the iPod, in facilitating the learning of young Australians with severe intellectual and social disabilities. The study, which was carried out in a segregated educational setting in Victoria, Australia, sought to establish whether the intrinsic portable, multi-media capabilities of the iPod particularly lent themselves to a practical application for students with severe disabilities. It was concluded that such new technology has considerable power and potential as an emerging pedagogy with students with severe intellectual and physical disabilities.
Description:
This paper explores the pedagogical and social potential of emerging technologies, in particular the iPod, in facilitating the learning of young Australians with severe intellectual and social disabilities. The study, which was carried out in a segregated educational setting in Victoria, Australia, sought to establish whether the intrinsic portable, multi-media capabilities of the iPod particularly lent themselves to a practical application for students with severe disabilities. It was concluded that such new technology has considerable power and potential as an emerging pedagogy with students with severe intellectual and physical disabilities.
Description:
Despite growing interest over recent years in applying reinforcement learning to multiobjective problems, there has been little research into the applicability and effectiveness of exploration strategies within the multiobjective context. This work considers several widely-used approaches to exploration from the single-objective reinforcement learning literature, and examines their incorporation into multiobjective Q-learning. In particular this paper proposes two novel approaches which extend the softmax operator to work with vector-valued rewards. The performance of these exploration strategies is evaluated across a set of benchmark environments. Issues arising from the multiobjective formulation of these benchmarks which impact on the performance of the exploration strategies are identified. It is shown that of the techniques considered, the combination of the novel softmax–epsilon exploration with optimistic initialisation provides the most effective trade-off between exploration and exploitation.
Description:
This paper presents findings from case studies of health consumers who each suspect they may have experienced an adverse drug reaction (ADR). These case studies are part of a larger study involving consumer/doctor decisions surrounding suspected adverse drug reactions and prescribing. Decision support to assist with the diagnosis and management of ADRs has, to date, primarily focused on providing in-time information to prescribers about factors that pertain to the consumer and the medications they are taking. Decision support that includes consumers usually targets treatment decisions. The results of this paper indicate the prescriber is only one decision contributor in a rich tapestry of decision contributors and decision types, and consumer decision types are significantly broader than treatment decisions. The results provide guidance for the development of decision support within this domain.
Description:
This paper presents findings from case studies of health consumers who each suspect they may have experienced an adverse drug reaction (ADR). These case studies are part of a larger study involving consumer/doctor decisions surrounding suspected adverse drug reactions and prescribing. Decision support to assist with the diagnosis and management of ADRs has, to date, primarily focused on providing in-time information to prescribers about factors that pertain to the consumer and the medications they are taking. Decision support that includes consumers usually targets treatment decisions. The results of this paper indicate the prescriber is only one decision contributor in a rich tapestry of decision contributors and decision types, and consumer decision types are significantly broader than treatment decisions. The results provide guidance for the development of decision support within this domain.
Description:
In this paper, we develop and put into practice an automatic optical inspection (AOI) system based on machine vision to check the holes on a printed circuit board (PCB). We incorporate the hardware and software. For the hardware part, we combine a PC, the three-axis positioning system, a lighting device, and charge-coupled device cameras. For the software part, we utilize image registration, image segmentation, drill numbering, drill contrast, and defect displays to achieve this system. Results indicated that an accuracy of 5 mu m could be achieved in errors of the PCB holes allowing comparisons to be made. This is significant in inspecting the missing, the multi-hole, and the incorrect location of the holes. However, previous work only focuses on one or other feature of the holes. Our research is able to assess multiple features: missing holes, incorrectly located holes, and excessive holes. Equally, our results could be displayed as a bar chart and target plot. This has not been achieved before. These displays help users to analyze the causes of errors and immediately correct the problems. In addition, this AOI system is valuable for checking a large number of holes and finding out the defective ones on a PCB. Meanwhile, we apply a 0.1-mm image resolution, which is better than others used in industry. We set a detecting standard based on 2-mm diameter of circles to diagnose the quality of the holes within 10 s.
Description:
In this paper, we develop and put into practice an automatic optical inspection (AOI) system based on machine vision to check the holes on a printed circuit board (PCB). We incorporate the hardware and software. For the hardware part, we combine a PC, the three-axis positioning system, a lighting device, and charge-coupled device cameras. For the software part, we utilize image registration, image segmentation, drill numbering, drill contrast, and defect displays to achieve this system. Results indicated that an accuracy of 5 mu m could be achieved in errors of the PCB holes allowing comparisons to be made. This is significant in inspecting the missing, the multi-hole, and the incorrect location of the holes. However, previous work only focuses on one or other feature of the holes. Our research is able to assess multiple features: missing holes, incorrectly located holes, and excessive holes. Equally, our results could be displayed as a bar chart and target plot. This has not been achieved before. These displays help users to analyze the causes of errors and immediately correct the problems. In addition, this AOI system is valuable for checking a large number of holes and finding out the defective ones on a PCB. Meanwhile, we apply a 0.1-mm image resolution, which is better than others used in industry. We set a detecting standard based on 2-mm diameter of circles to diagnose the quality of the holes within 10 s.
Description:
This paper presents a computational approach for predicting the Australian stock market index AORD using multi-layer feed-forward neural networks front the time series data of AORD and various interrelated markets. This effort aims to discover an effective neural network, or a set of adaptive neural networks for this prediction purpose, which can exploit or model various dynamical swings and inter-market influences discovered from professional technical analysis and quantitative analysis. Within a limited range defined by our empirical knowledge, three aspects of effectiveness on data selection are considered: effective inputs from the target market (AORD) itself, a sufficient set of interrelated markets,. and effective inputs from the interrelated markets. Two traditional dimensions of the neural network architecture are also considered: the optimal number of hidden layers, and the optimal number of hidden neurons for each hidden layer. Three important results were obtained: A 6-day cycle was discovered in the Australian stock market during the studied period; the time signature used as additional inputs provides useful information; and a basic neural network using six daily returns of AORD and one daily, returns of SP500 plus the day of the week as inputs exhibits up to 80% directional prediction correctness.
Description:
This paper presents a computational approach for predicting the Australian stock market index AORD using multi-layer feed-forward neural networks front the time series data of AORD and various interrelated markets. This effort aims to discover an effective neural network, or a set of adaptive neural networks for this prediction purpose, which can exploit or model various dynamical swings and inter-market influences discovered from professional technical analysis and quantitative analysis. Within a limited range defined by our empirical knowledge, three aspects of effectiveness on data selection are considered: effective inputs from the target market (AORD) itself, a sufficient set of interrelated markets,. and effective inputs from the interrelated markets. Two traditional dimensions of the neural network architecture are also considered: the optimal number of hidden layers, and the optimal number of hidden neurons for each hidden layer. Three important results were obtained: A 6-day cycle was discovered in the Australian stock market during the studied period; the time signature used as additional inputs provides useful information; and a basic neural network using six daily returns of AORD and one daily, returns of SP500 plus the day of the week as inputs exhibits up to 80% directional prediction correctness.
Description:
This paper presents the impact of twins and the measures for their removal from the population of genetic algorithm (GA) when applied to effective conformational searching. It is conclusively shown that a twin removal strategy for a GA provides considerably enhanced performance when investigating solutions to complex ab initio protein structure prediction (PSP) problems in low-resolution model. Without twin removal, GA crossover and mutation operations can become ineffectual as generations lose their ability to produce significant differences, which can lead to the solution stalling. The paper relaxes the definition of chromosomal twins in the removal strategy to not only encompass identical, but also highly correlated chromosomes within the GA population, with empirical results consistently exhibiting significant improvements solving PSP problems.
Description:
Abstract: Desolvation property is used here to predict protein-protein binding sites exploiting the fact that lower-valued 'optimal docking area' ODA (Fernandez-Recio et al., 2005) points form cluster at the interface. The proposed method involves two steps; clustering the ODA points and representing ODA points by average ODA values. On 51 nonredundant proteins, results show the success rate improved considerably. Considering only significant ODA, the previous ODA method has obtained a success rate of 65% with overall success rate of 39%. The proposed method improved the overall success rate to 61%. Further, comparable results were found for X-ray and NMR structures.
Description:
Incipient fault detection in low signal-to-noise ratio (SNR) conditions requires robust features for accurate condition-based machine health monitoring. Accurate fault classification is positively linked to the quality of features of the faults. Therefore, there is a need to enhance the quality of the features before classification. This paper presents a novel vibration spectrum imaging (VSI) feature enhancement procedure for low SNR conditions. An artificial neural network (ANN) has been used as a fault classifier using these enhanced features of the faults. The normalized amplitudes of spectral contents of the quasi-stationary time vibration signals are transformed into spectral images. A 2-D averaging filter and binary image conversion, with appropriate threshold selection, are used to filter and enhance the images for the training and testing of the ANN classifier. The proposed novel VSI augments and provides the visual representation of the characteristic vibration spectral features in an image form. This provides enhanced spectral images for ANN training and thus leads to a highly robust fault classifier.
Description:
Introduction There is substantial evidence to support the relationship between transcription skills (handwriting and spelling) and compositional quality. For children with developmental coordination disorder, handwriting can be particularly challenging. While recent research has aimed to investigate their handwriting difficulties in more detail, the impact of transcription on their compositional quality has not previously been examined. The aim of this exploratory study was to examine compositional quality in children with developmental coordination disorder and to ascertain whether their transcription skills influence writing quality. Method Twenty-eight children with developmental coordination disorder participated in the study, with 28 typically developing age and gender matched controls. The children completed the free-writing' task from the detailed assessment of speed of handwriting tool, which was evaluated for compositional quality using the Wechsler objective language dimensions. Results The children with developmental coordination disorder performed significantly below their typically developing peers on five of the six Wechsler objective language dimensions items. They also had a higher percentage of misspelled words. Regression analyses indicated that the number of words produced per minute and the percentage of misspelled words explained 55% of the variance for compositional quality. Conclusion The handwriting difficulties so commonly reported in children with developmental coordination disorder have wider repercussions for the quality of written composition.
Description:
Introduction There is substantial evidence to support the relationship between transcription skills (handwriting and spelling) and compositional quality. For children with developmental coordination disorder, handwriting can be particularly challenging. While recent research has aimed to investigate their handwriting difficulties in more detail, the impact of transcription on their compositional quality has not previously been examined. The aim of this exploratory study was to examine compositional quality in children with developmental coordination disorder and to ascertain whether their transcription skills influence writing quality. Method Twenty-eight children with developmental coordination disorder participated in the study, with 28 typically developing age and gender matched controls. The children completed the free-writing' task from the detailed assessment of speed of handwriting tool, which was evaluated for compositional quality using the Wechsler objective language dimensions. Results The children with developmental coordination disorder performed significantly below their typically developing peers on five of the six Wechsler objective language dimensions items. They also had a higher percentage of misspelled words. Regression analyses indicated that the number of words produced per minute and the percentage of misspelled words explained 55% of the variance for compositional quality. Conclusion The handwriting difficulties so commonly reported in children with developmental coordination disorder have wider repercussions for the quality of written composition.