In this paper we propose a novel technique of using a hybrid evolutionary method, which uses a combination of genetic algorithm and matrix based solution methods such as QR factorization. The training of the model is based on a layer based hierarchical structure for the architecture and the weights for the Artificial Neural Network classifier. The architecture for the classifier is found using a binary search type procedure. The hierarchical structured algorithm (EALS-BT) is also a hybrid, because it combines the Genetic Algorithm based method with the Matrix based solution method for finding weights. A heuristic segmentation algorithm is initially used to over segment each word. Then the segmentation points are passed through the rule-based module to discard the incorrect segmentation points and include any missing segmentation points. Following the segmentation the contour is extracted between two correct segmentation points. The contour is passed through the feature extraction module that extracts the angular features, after which the EALS-BT algorithm finds the architecture and the weights for the classifier network. These recognized characters are grouped into words and passed to a variable length lexicon that retrieves words that have the highest confidence value.
This paper presents the impact of twins and the measures for their removal from the population of genetic algorithm (GA) when applied to effective conformational searching. It is conclusively shown that a twin removal strategy for a GA provides considerably enhanced performance when investigating solutions to complex ab initio protein structure prediction (PSP) problems in low-resolution model. Without twin removal, GA crossover and mutation operations can become ineffectual as generations lose their ability to produce significant differences, which can lead to the solution stalling. The paper relaxes the definition of chromosomal twins in the removal strategy to not only encompass identical, but also highly correlated chromosomes within the GA population, with empirical results consistently exhibiting significant improvements solving PSP problems.