- Title
- A meta-analysis of gene expression signatures of blood pressure and hypertension
- Creator
- Charchar, Fadi
- Date
- 2015
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/160634
- Identifier
- vital:12206
- Identifier
-
https://doi.org/10.1371/journal.pgen.1005035
- Identifier
- ISBN:1553-7390
- Abstract
- Genome-wide association studies (GWAS) have uncovered numerous genetic variants (SNPs) that are associated with blood pressure (BP). Genetic variants may lead to BP changes by acting on intermediate molecular phenotypes such as coded protein sequence or gene expression, which in turn affect BP variability. Therefore, characterizing genes whose expression is associated with BP may reveal cellular processes involved in BP regulation and uncover how transcripts mediate genetic and environmental effects on BP variability. A meta-analysis of results from six studies of global gene expression profiles of BP and hypertension in whole blood was performed in 7017 individuals who were not receiving antihypertensive drug treatment. We identified 34 genes that were differentially expressed in relation to BP (Bonferroni-corrected p<0.05). Among these genes, FOS and PTGS2 have been previously reported to be involved in BP-related processes; the others are novel. The top BP signature genes in aggregate explain 5%–9% of inter-individual variance in BP. Of note, rs3184504 in SH2B3, which was also reported in GWAS to be associated with BP, was found to be a trans regulator of the expression of 6 of the transcripts we found to be associated with BP (FOS, MYADM, PP1R15A, TAGAP, S100A10, and FGBP2). Gene set enrichment analysis suggested that the BP-related global gene expression changes include genes involved in inflammatory response and apoptosis pathways. Our study provides new insights into molecular mechanisms underlying BP regulation, and suggests novel transcriptomic markers for the treatment and prevention of hypertension. **Please note that there are multiple authors for this article therefore only the name of the Federation University Australia affiliate is provided in this record**
- Publisher
- Public Library of Science
- Relation
- PLoS Genetics Vol. 11, no. 3 (2015), p. 1-29
- Rights
- https://creativecommons.org/publicdomain/zero/1.0/
- Rights
- This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
- Rights
- Open Access
- Rights
- This metadata is freely available under a CCO license
- Subject
- 0604 Genetics; Protein fos; Transcriptome; Apoptosis; Blood pressure regulation; FGBP2 gene; FOS gene; Gene cluster; Gene expression profiling; Gene expression regulation; Hypertension; MYADM gene; PP1R15A gene; PTGS2 gene; S100A10 gene; TAGAP gene; Genetic predisposition; Single nucleotide polymorphism
- Full Text
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