In this paper a Human–Vehicle–Road (HVR) model, comprising a quarter-car and a biomechanical representation of the driver, is employed for the analysis. Differential equations are provided to describe the motions of various masses under the inﬂuence of a harmonic road excitation. These equations are, subsequently, solved to obtain a closed form mathematical expression for the steady-state vertical acceleration measurable at the vehicle–human interface. The solution makes it possible to ﬁnd optimal parameters for the vehicle suspension system with respect to a speciﬁed ride comfort level. The quantitative deﬁnition given in the ISO 2631 standard for the ride comfort level is adopted in this paper for the optimization procedure. Numerical examples, based on actually measured road proﬁles, are presented to prove the validity of the proposed approach and its suitability for the problem at hand.