- Title
- A survey and a molecular dynamics study on the (central) hydrophobic region of prion proteins
- Creator
- Zhang, Jiapu; Wang, Feng
- Date
- 2014
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/77009
- Identifier
- vital:7654
- Identifier
- ISSN:1389-2010
- Abstract
- Prion diseases which are serious neurodegenerative diseases that affect humans and animals occur in various of species. Unlike many other neurodegenerative diseases affected by amyloid, prion diseases can be highly infectious. Prion diseases occur in many species. In humans, prion diseases include the fatal human neurodegenerative diseases such as Creutzfeldt-Jakob Disease (CJD), Fatal Familial Insomnia (FFI), Gerstmann-Strussler-Scheinker syndrome (GSS) and Kuru etc. In animals, prion diseases are related to the bovine spongiform encephalopathy (BSE or ‘mad-cow’ disease) in cattle, the chronic wasting disease (CWD) found in deer and elk, and scrapie seen in sheep and goats, etc. More seriously, the fact that transmission of the prion diseases across the species barrier to other species such as humans has caused a major public health concern worldwide. For example, the BSE in Europe, the CWD in North America, and variant CJDs (vCJDs) in young people of UK. Fortunately, it is discovered that the hydrophobic region of prion proteins (PrP) controls the formation of diseased prions (PrPSc), which provide some clues in control of such diseases. This article provides a detailed survey of recent studies with respect to the PrP hydrophobic region of human PrP(110–136) using molecular dynamics studies. © 2014 Bentham Science Publishers.
- Publisher
- Bentham Science Publishers B.V.
- Relation
- Current Pharmaceutical Biotechnology Vol. 15, no. 11 (2014), p. 1026-1048
- Rights
- Copyright © 2014 Bentham Science Publishers.
- Rights
- This metadata is freely available under a CCO license
- Subject
- 1004 Medical Biotechnology; 1115 Pharmacology and Pharmaceutical Sciences; A detailed survey; Central hydrophobic region; Molecular dynamics study; Prion diseases; Prion protein
- Reviewed
- Hits: 910
- Visitors: 892
- Downloads: 1
Thumbnail | File | Description | Size | Format |
---|