- Title
- The emerging role of non-coding RNA in essential hypertension and blood pressure regulation
- Creator
- Marques, Francine; Booth, Scott; Charchar, Fadi
- Date
- 2015
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/96394
- Identifier
- vital:10127
- Identifier
-
https://doi.org/10.1038/jhh.2014.99
- Identifier
- ISSN:0950-9240
- Abstract
- Unravelling the complete genetic predisposition to high blood pressure (BP) has proven to be challenging. This puzzle and the fact that coding regions of the genome account for less than 2% of the entire human DNA support the hypothesis that genetic mechanism besides coding genes are likely to contribute to BP regulation. Non-coding RNAs (ncRNAs) are emerging as key players of transcription regulation in both health and disease states. They control basic functions in virtually all cell types relevant to the cardiovascular system and, thus, a direct involvement with BP regulation is highly probable. Here, we review the literature about ncRNAs associated with human BP and essential hypertension, highlighting investigations, methodology and difficulties arising in the field. The most investigated ncRNAs so far are microRNAs (miRNAs), small ncRNAs that modulate gene expression by posttranscriptional mechanisms. We discuss studies that have examined miRNAs associated with BP in biological fluids, such as blood and urine, and tissues, such as vascular smooth muscle cells and the kidney. Furthermore, we review the interaction between miRNA binding sites and single nucleotide polymorphisms in genes associated with BP. In conclusion, there is a clear need for more human and functional studies to help elucidate the multifaceted roles of ncRNAs, in particular mid- and long ncRNAs in BP regulation. © 2015 Macmillan Publishers Limited All rights reserved.
- Publisher
- Nature Publishing Group
- Relation
- Journal of Human Hypertension Vol. 29, no. 8 (2015), p. 459-467; http://purl.org/au-research/grants/nhmrc/1009490
- Rights
- © 2015 Macmillan Publishers Limited. All rights reserved.
- Rights
- This metadata is freely available under a CCO license
- Subject
- 1103 Clinical Sciences; MicroRNA; Untranslated RNA; Blood pressure regulation; Cardiovascular disease; Cardiovascular system; Cells by body anatomy; Coronary artery disease; Essential hypertension; Gene expression; Genetic code; Heart ventricle hypertrophy; Human cytomegalovirus; Hypertension; In vitro gene transfer; Regulator gene; RNA extraction; Single nucleotide polymorphism; Stem cell; Transcription regulation; Vascular smooth muscle cell
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