- Serafini, Gianluca, Pompili, Maurizio, Innamorati, Marco, Amore, Mario, Borgwardt, Stefan, Giradi, Paolo, Temple, Elizabeth
- Authors: Serafini, Gianluca , Pompili, Maurizio , Innamorati, Marco , Amore, Mario , Borgwardt, Stefan , Giradi, Paolo , Temple, Elizabeth
- Date: 2013
- Type: Text , Journal article
- Relation: Frontiers in Pyschiatry Vol. 4, no. (2013), p. 1-5
- Full Text: false
- Reviewed:
- Description: Cannabis is one of the most common illegal psychoactive substance used in European countries, in particular among adolescents and young adults (1). It has been estimated that almost 55% of adolescents aged 15–19 years have used cannabis at least once in their lifetime (2), while past year use is reported by approximately 30% of 15–17 year olds and over 47% of those aged 18–19 years (3). Cannabis use has been associated with several adverse life outcomes including unemployment, legal problems, dependence, early school leaving, increased risk of developing both psychotic and affective disorders (3, 4) together with brain structural and functional abnormalities (5, 6). An association between cannabis use, psychiatric disorders and suicidal behavior has also frequently been reported, although the exact nature of this link is still poorly understood (4).
Cannabis use and anxiety : Is stress the missing piece of the puzzle?
- Temple, Elizabeth, Driver, Matthew, Brown, Rhonda
- Authors: Temple, Elizabeth , Driver, Matthew , Brown, Rhonda
- Date: 2014
- Type: Text , Journal article
- Relation: Frontiers in Psychiatry Vol. 5, no. (2014), p. 1-13
- Full Text:
- Reviewed:
- Description: Objective: Comorbidity between anxiety and cannabis use is common yet the nature of the association between these conditions is not clear. Four theories were assessed, and a fifth hypothesis tested to determine if the misattribution of stress symptomology plays a role in the association between state-anxiety and cannabis. Methods: Three-hundred-sixteen participants ranging in age from 18 to 71 years completed a short online questionnaire asking about their history of cannabis use and symptoms of stress and anxiety. Results: Past and current cannabis users reported higher incidence of lifetime anxiety than participants who had never used cannabis; however, these groups did not differ in state-anxiety, stress, or age of onset of anxiety. State-anxiety and stress were not associated with frequency of cannabis use, but reported use to self-medicate for anxiety was positively associated with all three. Path analyses indicated two different associations between anxiety and cannabis use, pre-existing and high state-anxiety was associated with (i) higher average levels of intoxication and, in turn, acute anxiety responses to cannabis use; (ii) frequency of cannabis use via the mediating effects of stress and self-medication. Conclusion: None of the theories was fully supported by the findings. However, as cannabis users reporting self-medication for anxiety were found to be self-medicating stress symptomology, there was some support for the stress-misattribution hypothesis. With reported self-medication for anxiety being the strongest predictor of frequency of use, it is suggested that researchers, clinicians, and cannabis users pay greater attention to the overlap between stress and anxiety symptomology and the possible misinterpretation of these related but distinct conditions. © 2014 Temple, Driver and Brown.
- Authors: Temple, Elizabeth , Driver, Matthew , Brown, Rhonda
- Date: 2014
- Type: Text , Journal article
- Relation: Frontiers in Psychiatry Vol. 5, no. (2014), p. 1-13
- Full Text:
- Reviewed:
- Description: Objective: Comorbidity between anxiety and cannabis use is common yet the nature of the association between these conditions is not clear. Four theories were assessed, and a fifth hypothesis tested to determine if the misattribution of stress symptomology plays a role in the association between state-anxiety and cannabis. Methods: Three-hundred-sixteen participants ranging in age from 18 to 71 years completed a short online questionnaire asking about their history of cannabis use and symptoms of stress and anxiety. Results: Past and current cannabis users reported higher incidence of lifetime anxiety than participants who had never used cannabis; however, these groups did not differ in state-anxiety, stress, or age of onset of anxiety. State-anxiety and stress were not associated with frequency of cannabis use, but reported use to self-medicate for anxiety was positively associated with all three. Path analyses indicated two different associations between anxiety and cannabis use, pre-existing and high state-anxiety was associated with (i) higher average levels of intoxication and, in turn, acute anxiety responses to cannabis use; (ii) frequency of cannabis use via the mediating effects of stress and self-medication. Conclusion: None of the theories was fully supported by the findings. However, as cannabis users reporting self-medication for anxiety were found to be self-medicating stress symptomology, there was some support for the stress-misattribution hypothesis. With reported self-medication for anxiety being the strongest predictor of frequency of use, it is suggested that researchers, clinicians, and cannabis users pay greater attention to the overlap between stress and anxiety symptomology and the possible misinterpretation of these related but distinct conditions. © 2014 Temple, Driver and Brown.
The influence of an attachment-related stimulus on oxytocin reactivity in poly-drug users undergoing maintenance therapy compared to healthy controls
- Fuchshuber, Jürgen, Tatzer, Jasmin, Hiebler-Ragger, Michaela, Trinkl, Florian, Kimmerle, Andreas, Rinner, Anita, Buchheim, Anna, Schrom, Silke, Rinner, Beate, Leber, Klaus, Pieber, Thomas, Weiss, Elisabeth, Lewis, Andrew, Kapfhammer, Hans-Peter, Unterrainer, Human
- Authors: Fuchshuber, Jürgen , Tatzer, Jasmin , Hiebler-Ragger, Michaela , Trinkl, Florian , Kimmerle, Andreas , Rinner, Anita , Buchheim, Anna , Schrom, Silke , Rinner, Beate , Leber, Klaus , Pieber, Thomas , Weiss, Elisabeth , Lewis, Andrew , Kapfhammer, Hans-Peter , Unterrainer, Human
- Date: 2020
- Type: Text , Journal article
- Relation: Frontiers in Psychiatry Vol. 11, no. (2020), p. 460506
- Full Text:
- Reviewed:
- Description: Substance use disorders (SUDs) have been described as a dysfunctional way to compensate for deficiencies in that person's underlying attachment system. Furthermore, the neuropeptide oxytocin (OT), which is a critical component of the neurobiology of the attachment system, has been shown to effectively reduce addictive behavior and therefore has been discussed as a potential medication in SUD treatment. This study investigates variation in peripheral OT plasma levels as a function of exposure to an attachment-related stimulus in SUD patients compared to healthy controls (HCs). A total sample of 48 men, 24 inpatients in maintenance treatment who were diagnosed with poly-drug use disorder (PUD) and 24 HC, was investigated. A 15-min exposure to the Adult Attachment Projective Picture System (AAP) was used as an attachment-related stimulus and coded for attachment status. Blood samples before and after the AAP-assessment were taken and assayed for OT levels. Variation in baselines level of OT was examined in relation to the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST), the Adult Attachment-Scale (AAS), and the Brief Symptom Inventory (BSI). Following the AAP stimulus controls showed no significant difference in OT levels elevation from baseline compared to the PUD group's OT levels. Furthermore, in the PUD group only OT-baseline-levels may be negatively associated with the AAS subscale "Comfort with Closeness" and "Anxiety" and lifetime substance use. Our results suggest that peripheral OT levels in poly-drug users undergoing maintenance treatment are not significantly different in responsiveness to an attachment related stimulus compared to HC. With regard to non-significant tendencies observed in this study which hint toward decreased OT-reactivity in the PUD group, further research is needed to explore this hypothesis with increased statistical power.
- Authors: Fuchshuber, Jürgen , Tatzer, Jasmin , Hiebler-Ragger, Michaela , Trinkl, Florian , Kimmerle, Andreas , Rinner, Anita , Buchheim, Anna , Schrom, Silke , Rinner, Beate , Leber, Klaus , Pieber, Thomas , Weiss, Elisabeth , Lewis, Andrew , Kapfhammer, Hans-Peter , Unterrainer, Human
- Date: 2020
- Type: Text , Journal article
- Relation: Frontiers in Psychiatry Vol. 11, no. (2020), p. 460506
- Full Text:
- Reviewed:
- Description: Substance use disorders (SUDs) have been described as a dysfunctional way to compensate for deficiencies in that person's underlying attachment system. Furthermore, the neuropeptide oxytocin (OT), which is a critical component of the neurobiology of the attachment system, has been shown to effectively reduce addictive behavior and therefore has been discussed as a potential medication in SUD treatment. This study investigates variation in peripheral OT plasma levels as a function of exposure to an attachment-related stimulus in SUD patients compared to healthy controls (HCs). A total sample of 48 men, 24 inpatients in maintenance treatment who were diagnosed with poly-drug use disorder (PUD) and 24 HC, was investigated. A 15-min exposure to the Adult Attachment Projective Picture System (AAP) was used as an attachment-related stimulus and coded for attachment status. Blood samples before and after the AAP-assessment were taken and assayed for OT levels. Variation in baselines level of OT was examined in relation to the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST), the Adult Attachment-Scale (AAS), and the Brief Symptom Inventory (BSI). Following the AAP stimulus controls showed no significant difference in OT levels elevation from baseline compared to the PUD group's OT levels. Furthermore, in the PUD group only OT-baseline-levels may be negatively associated with the AAS subscale "Comfort with Closeness" and "Anxiety" and lifetime substance use. Our results suggest that peripheral OT levels in poly-drug users undergoing maintenance treatment are not significantly different in responsiveness to an attachment related stimulus compared to HC. With regard to non-significant tendencies observed in this study which hint toward decreased OT-reactivity in the PUD group, further research is needed to explore this hypothesis with increased statistical power.
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