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Cardiovascular diseases and G-protein beta 3 subunit gene (GNB3) in the era of genomewide scans

- Tomaszewski, Maciej, Charchar, Fadi, Padmanabhan, Sandosh, Zukowska-Szczechowska, Ewa, Grzeszczak, Wladyslaw, Dominiczak, Anna

The pressure of finding human hypertension genes : New tools, old dilemmas

- Charchar, Fadi, Zimmerli, Lukas, Tomaszewski, Maciej

  • Authors: Charchar, Fadi , Zimmerli, Lukas , Tomaszewski, Maciej
  • Date: 2008
  • Type: Text , Journal article
  • Relation: Journal of Human Hypertension Vol. 22, no. (2008), p. 821–828
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  • Description: Researchers in hypertension genetics feel like they are left behind again. It always seems that the 'other' complex diseases are ahead in the race. Evolving new technologies in the form of genome-wide arrays and 'omics' technologies mean that investigators can now potentially identify many novel disease factors in one large-scale experiment. Hypertension research now faces the challenge of where to go next after the first genome-wide association experiments failed to provide robust candidates. In this review, we contemplate the old dilemma of whether such genes may ever be found; however, we believe advancing technologies and plummeting costs of large-scale experiments will contribute to the identification of novel molecules that underlie essential hypertension.

Novel insights into essential hypertension etiology revealed by genome-wide gene expression profiling of human kidneys: evidence for renin involvement via a microRNA-mediated effect on expression

- Marques, Francine, Campain, Anna, Tomaszewski, Maciej, Zukowska-Szczechowska, Ewa, Yang, Yee, Charchar, Fadi, Morris, Brian

Up-regulation of autophagic pathways early in life might contribute to cardiac hypertrophy in a heritable polygenic model

- Marques, Francine, Quarrell, Sean, Jayaswal, Vivek, Curl, Claire, Nankervis, Scott, Yang, Jean, Delbridge, Lea, Harrap, Stephen, Charchar, Fadi

The emerging role of non-coding RNA in essential hypertension and blood pressure regulation

- Marques, Francine, Booth, Scott, Charchar, Fadi

  • Authors: Marques, Francine , Booth, Scott , Charchar, Fadi
  • Date: 2015
  • Type: Text , Journal article
  • Relation: Journal of Human Hypertension Vol. 29, no. 8 (2015), p. 459-467
  • Relation: http://purl.org/au-research/grants/nhmrc/1009490
  • Full Text: false
  • Reviewed:
  • Description: Unravelling the complete genetic predisposition to high blood pressure (BP) has proven to be challenging. This puzzle and the fact that coding regions of the genome account for less than 2% of the entire human DNA support the hypothesis that genetic mechanism besides coding genes are likely to contribute to BP regulation. Non-coding RNAs (ncRNAs) are emerging as key players of transcription regulation in both health and disease states. They control basic functions in virtually all cell types relevant to the cardiovascular system and, thus, a direct involvement with BP regulation is highly probable. Here, we review the literature about ncRNAs associated with human BP and essential hypertension, highlighting investigations, methodology and difficulties arising in the field. The most investigated ncRNAs so far are microRNAs (miRNAs), small ncRNAs that modulate gene expression by posttranscriptional mechanisms. We discuss studies that have examined miRNAs associated with BP in biological fluids, such as blood and urine, and tissues, such as vascular smooth muscle cells and the kidney. Furthermore, we review the interaction between miRNA binding sites and single nucleotide polymorphisms in genes associated with BP. In conclusion, there is a clear need for more human and functional studies to help elucidate the multifaceted roles of ncRNAs, in particular mid- and long ncRNAs in BP regulation. © 2015 Macmillan Publishers Limited All rights reserved.
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