- Title
- Hypouricemia is a risk factor for diabetes in Chinese adults
- Creator
- Wang, Yutang; Shao, Yanan; Qian, Tingting; Sun, Hui; Xu, Qun; Hou, Xujuan; Hu, Wenqi; Zhang, Guang; Song, David; Fang, Yan; Magliano, Dianna; Witting, Paul; Golledge, Jonathan; Yang, Guang
- Date
- 2022
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/189238
- Identifier
- vital:17430
- Identifier
-
https://doi.org/10.1016/j.obmed.2022.100405
- Identifier
- ISSN:2451-8476 (ISSN)
- Abstract
- Aims: It is unknown whether low serum uric acid (hypouricemia) is associated with diabetes diagnosis. This study aimed to investigate this association in Chinese adults. Methods: This cross-sectional study included 22,546 Chinese adults. The reference interval for serum uric acid was determined in a sub-group of healthy individuals. The association between hypouricemia and diabetes was analyzed using binary logistic regression. Results: The serum uric acid reference intervals were 3.78–8.31 mg/dL for males and 2.76–6.24 mg/dL for females. Hypouricemia was defined as serum uric acid concentration <3.78 mg/dL for males and <2.76 mg/dL for females. Hypouricemia was associated with an increased likelihood of diabetes diagnosis in both unadjusted (odds ratio [OR], 2.23; 95% confidence interval [CI], 1.78–2.79) and risk factor adjusted (OR, 2.67; 95% CI, 2.08–3.43) analyses. In a sub-group analysis, hypouricemia was significantly independently associated with an increased likelihood of diabetes diagnosis in males but not females. Conclusion: This study suggests that hypouricemia is independently associated with an increased risk of diabetes diagnosis. The findings should be validated in prospective cohort studies. © 2022 Elsevier Ltd
- Publisher
- Elsevier Ltd
- Relation
- Obesity Medicine Vol. 31, no. (2022), p.; https://purl.org/au-research/grants/nhmrc/1062671
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- Copyright © 2022 Elsevier Ltd
- Rights
- Open Access
- Subject
- 3210 Nutrition and dietetics; 4206 Public health; Diabetes mellitus; Hyperuricemia; Hypouricemia; Risk factor; Uric acid
- Full Text
- Reviewed
- Funder
- This work was funded by the Shandong Natural Fund (ZR2015HL008), Shandong Province, China . YW was supported by a grant from the National Health and Medical Research Council of Australia ( 1062671 ). JG holds a Practitioner Fellowship from the National Health and Medical Research Council (1117061). JG also holds a Senior Clinical Research Fellowship from the Queensland Government , Australia.
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