Cancer incidence and soil arsenic exposure in a historical gold mining area in Victoria, Australia : A geospatial analysis
- Pearce, Dora, Dowling, Kim, Sim, Malcolm
- Authors: Pearce, Dora , Dowling, Kim , Sim, Malcolm
- Date: 2012
- Type: Text , Journal article
- Relation: Journal of Exposure Science and Environmental Epidemiology Vol. 22, no. 3 (2012), p. 248-257
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- Description: Soil and mine waste around historical gold mining sites may have elevated arsenic concentrations. Recent evidence suggests some systemic arsenic absorption by residents in the goldfields region of Victoria, Australia. Victorian Cancer Registry and geochemical data were accessed for an ecological geographical correlation study, 1984-2003. Spatial empirical Bayes smoothing was applied when estimating standardised incidence ratios (SIRs) for cancers in 61 statistical local areas. The derived soil arsenic exposure metric ranged from 1.4 to 1857 mg/kg. Spatial autoregressive modelling detected increases in smoothed SIRs for all cancers of 0.05 (95% confidence interval (CI), 0.02-0.08) and 0.04 (0.01-0.07) per 2.7-fold increase in the natural log-transformed exposure metric for males and females, respectively, in more socioeconomically disadvantaged areas; for melanoma in males (0.05 (0.01-0.08) adjusted for disadvantage) and females (0.05 (0.02-0.09) in disadvantaged areas). Excess risks were estimated for all cancers (relative risk 1.21 (95% CI, 1.15-1.27) and 1.08 (1.03-1.14)), and melanoma (1.52 (1.25-1.85) and 1.29 (1.08-1.55)), for males and females, respectively, in disadvantaged areas in the highest quintile of the exposure metric relative to the lowest. Our findings suggest small but significant increases in past cancer risk associated with increasing soil arsenic in socioeconomically disadvantaged areas and demonstrate the robustness of this geospatial approach. Journal of Exposure Science and Environmental Epidemiology advance online publication, 21 March 2012.
- Authors: Pearce, Dora , Dowling, Kim , Sim, Malcolm
- Date: 2012
- Type: Text , Journal article
- Relation: Journal of Exposure Science and Environmental Epidemiology Vol. 22, no. 3 (2012), p. 248-257
- Full Text:
- Reviewed:
- Description: Soil and mine waste around historical gold mining sites may have elevated arsenic concentrations. Recent evidence suggests some systemic arsenic absorption by residents in the goldfields region of Victoria, Australia. Victorian Cancer Registry and geochemical data were accessed for an ecological geographical correlation study, 1984-2003. Spatial empirical Bayes smoothing was applied when estimating standardised incidence ratios (SIRs) for cancers in 61 statistical local areas. The derived soil arsenic exposure metric ranged from 1.4 to 1857 mg/kg. Spatial autoregressive modelling detected increases in smoothed SIRs for all cancers of 0.05 (95% confidence interval (CI), 0.02-0.08) and 0.04 (0.01-0.07) per 2.7-fold increase in the natural log-transformed exposure metric for males and females, respectively, in more socioeconomically disadvantaged areas; for melanoma in males (0.05 (0.01-0.08) adjusted for disadvantage) and females (0.05 (0.02-0.09) in disadvantaged areas). Excess risks were estimated for all cancers (relative risk 1.21 (95% CI, 1.15-1.27) and 1.08 (1.03-1.14)), and melanoma (1.52 (1.25-1.85) and 1.29 (1.08-1.55)), for males and females, respectively, in disadvantaged areas in the highest quintile of the exposure metric relative to the lowest. Our findings suggest small but significant increases in past cancer risk associated with increasing soil arsenic in socioeconomically disadvantaged areas and demonstrate the robustness of this geospatial approach. Journal of Exposure Science and Environmental Epidemiology advance online publication, 21 March 2012.
Arsenic microdistribution and speciation in toenail clippings of children living in a historic gold mining area
- Pearce, Dora, Dowling, Kim, Gerson, Andrea, Sim, Malcolm, Sutton, Stephen, Newville, Matthew, Russell, Robert, McOrist, Gordon
- Authors: Pearce, Dora , Dowling, Kim , Gerson, Andrea , Sim, Malcolm , Sutton, Stephen , Newville, Matthew , Russell, Robert , McOrist, Gordon
- Date: 2010
- Type: Text , Journal article
- Relation: Science of the Total Environment Vol. 408, no. 12 (2010), p. 2590-2599
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- Description: Arsenic is naturally associated with gold mineralisation and elevated in some soils and mine waste around historical gold mining activity in Victoria, Australia. To explore uptake, arsenic concentrations in children's toenail clippings and household soils were measured, and the microdistribution and speciation of arsenic in situ in toenail clipping thin sections investigated using synchrotron-based X-ray microprobe techniques. The ability to differentiate exogenous arsenic was explored by investigating surface contamination on cleaned clippings using depth profiling, and direct diffusion of arsenic into incubated clippings. Total arsenic concentrations ranged from 0.15 to 2.1
- Authors: Pearce, Dora , Dowling, Kim , Gerson, Andrea , Sim, Malcolm , Sutton, Stephen , Newville, Matthew , Russell, Robert , McOrist, Gordon
- Date: 2010
- Type: Text , Journal article
- Relation: Science of the Total Environment Vol. 408, no. 12 (2010), p. 2590-2599
- Full Text:
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- Description: Arsenic is naturally associated with gold mineralisation and elevated in some soils and mine waste around historical gold mining activity in Victoria, Australia. To explore uptake, arsenic concentrations in children's toenail clippings and household soils were measured, and the microdistribution and speciation of arsenic in situ in toenail clipping thin sections investigated using synchrotron-based X-ray microprobe techniques. The ability to differentiate exogenous arsenic was explored by investigating surface contamination on cleaned clippings using depth profiling, and direct diffusion of arsenic into incubated clippings. Total arsenic concentrations ranged from 0.15 to 2.1
Ever and cumulative occupational exposure and lung function decline in longitudinal population-based studies : a systematic review and meta-analysis
- Rabbani, Golam, Nimmi, Naima, Benke, Geza, Dharmage, Shyamali, Bui, Dinh, Sim, Malcolm, Abramson, Michael, Alif, Sheikh
- Authors: Rabbani, Golam , Nimmi, Naima , Benke, Geza , Dharmage, Shyamali , Bui, Dinh , Sim, Malcolm , Abramson, Michael , Alif, Sheikh
- Date: 2022
- Type: Text , Journal article , Review
- Relation: Occupational and Environmental Medicine Vol. 80, no. 1 (2022), p. 51-60
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- Description: Objectives Adverse occupational exposures can accelerate age-related lung function decline. Some longitudinal population-based studies have investigated this association. This study aims to examine this association using findings reported by longitudinal population-based studies. Methods Ovid Medline, PubMed, Embase, and Web of Science were searched using keywords and text words related to occupational exposures and lung function and 12 longitudinal population-based studies were identified using predefined inclusion criteria. The quality of the studies was assessed using the Newcastle-Ottawa Scale. Lung function decline was defined as annual loss of forced expiratory volume in 1 s (FEV 1), forced vital capacity (FVC) or the ratio (FEV 1 /FVC). Fixed and random-effects meta-analyses were conducted to calculate pooled estimates for ever and cumulative exposures. Heterogeneity was assessed using the I 2 test, and publication bias was evaluated using funnel plots. Results Ever exposures to gases/fumes, vapours, gases, dusts, fumes (VGDF) and aromatic solvents were significantly associated with FEV 1 decline in meta-analyses. Cumulative exposures for these three occupational agents observed a similar trend of FEV 1 decline. Ever exposures to fungicides and cumulative exposures to biological dust, fungicides and insecticides were associated with FEV 1 decline in fixed-effect models only. No statistically significant association was observed between mineral dust, herbicides and metals and FEV 1 decline in meta-analyses. Conclusion Pooled estimates from the longitudinal population-based studies have provided evidence that occupational exposures are associated with FEV 1 decline. Specific exposure control and respiratory health surveillance are required to protect the lung health of the workers. © 2023 Author(s). Published by BMJ.
- Authors: Rabbani, Golam , Nimmi, Naima , Benke, Geza , Dharmage, Shyamali , Bui, Dinh , Sim, Malcolm , Abramson, Michael , Alif, Sheikh
- Date: 2022
- Type: Text , Journal article , Review
- Relation: Occupational and Environmental Medicine Vol. 80, no. 1 (2022), p. 51-60
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- Description: Objectives Adverse occupational exposures can accelerate age-related lung function decline. Some longitudinal population-based studies have investigated this association. This study aims to examine this association using findings reported by longitudinal population-based studies. Methods Ovid Medline, PubMed, Embase, and Web of Science were searched using keywords and text words related to occupational exposures and lung function and 12 longitudinal population-based studies were identified using predefined inclusion criteria. The quality of the studies was assessed using the Newcastle-Ottawa Scale. Lung function decline was defined as annual loss of forced expiratory volume in 1 s (FEV 1), forced vital capacity (FVC) or the ratio (FEV 1 /FVC). Fixed and random-effects meta-analyses were conducted to calculate pooled estimates for ever and cumulative exposures. Heterogeneity was assessed using the I 2 test, and publication bias was evaluated using funnel plots. Results Ever exposures to gases/fumes, vapours, gases, dusts, fumes (VGDF) and aromatic solvents were significantly associated with FEV 1 decline in meta-analyses. Cumulative exposures for these three occupational agents observed a similar trend of FEV 1 decline. Ever exposures to fungicides and cumulative exposures to biological dust, fungicides and insecticides were associated with FEV 1 decline in fixed-effect models only. No statistically significant association was observed between mineral dust, herbicides and metals and FEV 1 decline in meta-analyses. Conclusion Pooled estimates from the longitudinal population-based studies have provided evidence that occupational exposures are associated with FEV 1 decline. Specific exposure control and respiratory health surveillance are required to protect the lung health of the workers. © 2023 Author(s). Published by BMJ.
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