- Title
- Adjustment for body mass index changes inverse associations of HDL-cholesterol with blood pressure and hypertension to positive associations
- Creator
- Yang, Guang; Qian, Tingting; Sun, Hui; Xu, Qun; Hou, Xujuan; Hu, Wenqi; Zhang, Guang; Drummond, Grant; Sobey, Christopher; Witting, Paul; Denton, Kate; Charchar, Fadi; Golledge, Jonathan; Wang, Yutang
- Date
- 2022
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/186650
- Identifier
- vital:16947
- Identifier
-
https://doi.org/10.1038/s41371-021-00548-x
- Identifier
- ISBN:0950-9240 (ISSN)
- Abstract
- The associations between high-density lipoprotein cholesterol (HDL-C) and blood pressure (BP) or hypertension are inconsistent in previous studies. This study aimed to assess these associations in a large cohort of Chinese adults and across different age groups. This cross-sectional association study included 22,081 Chinese adults. Associations of HDL-C with BP and hypertension were analyzed using linear or logistic regression, with or without adjustment for confounding factors. HDL-C was inversely associated with BP and hypertension. These associations were still apparent after adjustment for age, sex, fasting plasma glucose, and low-density lipoprotein cholesterol. Sub-analyses revealed: (1) in the whole cohort and females alone, HDL-C was inversely associated with BP and hypertension in young and middle-aged but not older participants; (2) in males alone, HDL-C was not associated with systolic BP or hypertension. However, HDL-C was either inversely, or not, or positively associated with BP in young, middle-aged, and older males, respectively. After further adjustment for body mass index (BMI), the negative associations of HDL-C with BP and hypertension in the whole cohort became positive ones, and the positive associations only presented in males. These findings suggest that further adjustment for BMI changes inverse associations of HDL-cholesterol with BP and hypertension to positive associations in a cohort of Chinese adults. © 2021, The Author(s), under exclusive licence to Springer Nature Limited.
- Publisher
- Springer Nature
- Relation
- Journal of Human Hypertension Vol. 36, no. 6 (2022), p. 570-579; https://purl.org/au-research/grants/nhmrc/1062671
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- Copyright © 2021, The Author(s)
- Rights
- Open Access
- Subject
- 3201 Cardiovascular medicine and haematology; 3202 Clinical sciences
- Full Text
- Reviewed
- Funder
- Funding This work was funded by the Shandong Natural Fund (ZR2015HL008), Shandong Province, China. YW is supported by a grant from the National Health and Medical Research Council of Australia (1062671).
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