Optimization of novel 1-Methyl-1H-Pyrazole-5-carboxamides leads to high potency larval development inhibitors of the Barber's pole worm

Title: Optimization of novel 1-Methyl-1H-Pyrazole-5-carboxamides leads to high potency larval development inhibitors of the Barber's pole worm
Creator: Le, Thuy; Kunda, Abhijit; Ghoshal, Atanu; Preston, Sarah; Jiao, Yaqing; Ruan, Banfeng; Xue, Lian; Huang, Fei; Keiser, Jennifer; Hofmann, Andreas; Chang, Bill; Garcia-Bustos, Jose; Jabbar, Abdul; Wells, Timothy; Palmer, Michael; Gasser, Robin; Baell, Jonathan
Date: 2018
Type: Text; Journal article
Identifier: http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/167686
Identifier: vital:13694
Identifier: https://doi.org/10.1021/acs.jmedchem.8b01544
Identifier: ISBN:0022-2623
Abstract: A phenotypic screen of a diverse library of small molecules for inhibition of the development of larvae of the parasitic nematode Haemonchus contortus led to the identification of a 1-methyl-1H-pyrazole-5-carboxamide derivative with an IC
Publisher: American Chemical Society
Relation: Journal of Medicinal Chemistry Vol. 61, no. 23 (2018), p. 10875-10894
Rights: This metadata is freely available under a CCO license
Subject: 0304 Medicinal and Biomolecular Chemistry; 0305 Organic Chemistry; 1115 Pharmacology and Pharmaceutical Sciences; Anthelmintics; Sheep; Anthelmintic drugs
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